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Emerging Antibody-based Products

  • Kevin J. WhaleyEmail author
  • Josh Morton
  • Steve Hume
  • Ernie Hiatt
  • Barry Bratcher
  • Victor Klimyuk
  • Andrew Hiatt
  • Michael Pauly
  • Larry Zeitlin
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 375)

Abstract

Antibody-based products are not widely available to address many global health challenges due to high costs, limited manufacturing capacity, and long manufacturing lead times. There are now tremendous opportunities to address these industrialization challenges as a result of revolutionary advances in plant virus-based transient expression. This review focuses on some antibody-based products that are in preclinical and clinical development, and have scaled up manufacturing and purification (mg of purified mAb/kg of biomass). Plant virus-based antibody products provide lower upfront cost, shorter time to clinical and market supply, and lower cost of goods (COGs). Further, some plant virus-based mAbs may provide improvements in pharmacokinetics, safety and efficacy.

Keywords

Antibody magnICON Industrialization Nicotiana Products Manufacturing Transient Expression Gemini Glycan Modification 

List of abbreviations and acronyms

mAb

monoclonal antibody

HIV

human immunodeficiency virus

HSV

herpes simplex virus

RSV

respiratory syncytial virus

∆XF

xylose and fucose knockout

CHO

Chinese hamster ovary

gD

glycoprotein D

NHL

Non-Hodgkin’s lymphoma

F-L

follicular B-cell lymphoma

GnGn

human like biantennary N-glycans with terminal N-acetylglucosamine on each branch

CHT

ceramic hydroxyapatite

Notes

Acknowledgments

Some of the work described was supported by grant numbers U19AI096398, AI62150, AI061270, AI063681, from NIAID, DAMD 17-02-2-0015 from the department of defense, and partially supported by the defense threat reduction agency grant no. 4.10007-08-RD-B. The content is solely the responsibility of the authors and does not necessarily represent the official views of the national institutes of health, U.S. Army, or department of defense.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Kevin J. Whaley
    • 1
    Email author
  • Josh Morton
    • 2
  • Steve Hume
    • 2
  • Ernie Hiatt
    • 2
  • Barry Bratcher
    • 2
  • Victor Klimyuk
    • 3
  • Andrew Hiatt
    • 1
  • Michael Pauly
    • 1
  • Larry Zeitlin
    • 1
  1. 1.Mapp Biopharmaceutical IncSan DiegoUSA
  2. 2.Kentucky BioProcessingOwensboroUSA
  3. 3.Icon Genetics GmBHHalle (Saale)Germany

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