Henipavirus pp 197-223 | Cite as

Immunization Strategies Against Henipaviruses

  • Christopher C. Broder
  • Thomas W. Geisbert
  • Kai Xu
  • Dimitar B. Nikolov
  • Lin-Fa Wang
  • Deborah Middleton
  • Jackie Pallister
  • Katharine N. Bossart
Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 359)

Abstract

Hendra virus and Nipah virus are recently discovered and closely related emerging viruses that now comprise the genus henipavirus within the sub-family Paramyxoviridae and are distinguished by their broad species tropism and in addition to bats can infect and cause fatal disease in a wide variety of mammalian hosts including humans. The high mortality associated with human and animal henipavirus infections has highlighted the importance and necessity of developing effective immunization strategies. The development of suitable animal models of henipavirus infection and pathogenesis has been critical for testing the efficacy of potential therapeutic approaches. Several henipavirus challenge models have been used and recent successes in both active and passive immunization strategies against henipaviruses have been reported which have all targeted the viral envelope glycoproteins.

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© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Christopher C. Broder
    • 1
  • Thomas W. Geisbert
    • 2
  • Kai Xu
    • 3
  • Dimitar B. Nikolov
    • 3
  • Lin-Fa Wang
    • 4
  • Deborah Middleton
    • 4
  • Jackie Pallister
    • 4
  • Katharine N. Bossart
    • 5
    • 6
  1. 1.Department of Microbiology and ImmunologyUniformed Services UniversityBethesdaUSA
  2. 2.Galveston National Laboratory and Department of Microbiology and ImmunologyUniversity of Texas Medical BranchGalvestonUSA
  3. 3.Structural Biology ProgramMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  4. 4.CSIRO Livestock IndustriesAustralian Animal Health LaboratoryGeelongAustralia
  5. 5.Department of MicrobiologyBoston University School of MedicineBostonUSA
  6. 6.National Emerging Infectious Diseases Laboratories InstituteBoston University School of MedicineBostonUSA

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