Role of Carcinoma-Associated Fibroblasts and Hypoxia in Tumor Progression

  • Amato J. Giaccia
  • Ernestina Schipani
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 345)


In recent years, a variety of experimental evidence has convincingly shown that progression of malignant tumors does not depend exclusively on cell-autonomous properties of the cancer cells, but can also be influenced by the tumor stroma. The concept that cancer cells are subjected to microenvironmental control has thus emerged as an important chapter in cancer biology. Recent findings have suggested an important role, in particular, for macrophages, endothelial cells, and cancer-associated fibroblasts (CAFs) in tumor growth and progression. Numerous lines of evidence indicate that the bone marrow is the source, at least in part, of these cells. This chapter summarizes our current knowledge of how bone marrow contributes to the tumor stroma, with particular emphasis on CAFs. The potential role of hypoxia in modulating the differentiation and activity of CAFs, and the therapeutical implications of targeting CAFs for anticancer therapy are discussed.


Hepatocyte Growth Factor Tumor Stroma Adult Bone Marrow Bone Marrow Origin Hepatocyte Growth Factor Signaling 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  1. 1.Department of Radiation Oncology, Division of Cancer and Radiation BiologyStanford University School of MedicineStanfordUSA
  2. 2.Department of Medicine, Endocrine UnitMGH-Harvard Medical SchoolBostonUSA

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