NF-kB in Health and Disease

Volume 349 of the series Current Topics in Microbiology and Immunology pp 97-114


Control of NF-κB Activity by Proteolysis

  • Véronique BaudAffiliated withInstitut Cochin, Université Paris Descartes, CNRS (UMR 8104)Inserm, U1016 Email author 
  • , Emmanuel DerudderAffiliated withProgram in Cellular and Molecular Medicine at Children’s Hospital, Immune Disease Institute, Harvard Medical School

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NF-κB transcription factors are critical regulators of many biological processes such as innate and adaptive immune responses, inflammation, cell proliferation and programmed cell death. This versatility necessitates a highly complex and tightly coordinated control of the signaling pathways leading to their activation. Here, we review the role of proteolysis in the regulation of NF-κB activity, more specifically the contribution of the well-known ubiquitin–proteasome system and the involvement of proteolytic activity of caspases and calpains.