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Affective Biases in Humans and Animals

  • E.S.J. Robinson
  • J.P. Roiser
Chapter
Part of the Current Topics in Behavioral Neurosciences book series (CTBN, volume 28)

Abstract

Depression is one of the most common but poorly understood psychiatric conditions. Although drug treatments and psychological therapies are effective in some patients, many do not achieve full remission and some patients receive no apparent benefit. Developing new improved treatments requires a better understanding of the aetiology of symptoms and evaluation of novel therapeutic targets in pre-clinical studies. Recent developments in our understanding of the basic cognitive processes that may contribute to the development of depression and its treatment offer new opportunities for both clinical and pre-clinical research. This chapter discusses the clinical evidence supporting a cognitive neuropsychological model of depression and antidepressant efficacy, and how this information may be usefully translated to pre-clinical investigation. Studies using neuropsychological tests in depressed patients and at risk populations have revealed basic negative emotional biases and disrupted reward and punishment processing, which may also impact on non-affective cognition. These affective biases are sensitive to antidepressant treatments with early onset effects observed, suggesting an important role in recovery. This clinical work into affective biases has also facilitated back-translation to animals and the development of assays to study affective biases in rodents. These animal studies suggest that, similar to humans, rodents in putative negative affective states exhibit negative affective biases on decision-making and memory tasks. Antidepressant treatments also induce positive biases in these rodent tasks, supporting the translational validity of this approach. Although still in the early stages of development and validation, affective biases in depression have the potential to offer new insights into the clinical condition, as well as facilitating the development of more translational approaches for pre-clinical studies.

Keywords

Emotion Reward Rodents Animal model Major depressive disorder Antidepressants 

Notes

Acknowledgments and Disclosures

ESJR currently holds research funding from the MRC, BBSRC, Wellcome Trust, and Eli Lilly. Previous support which has contributed to the development of this work includes funding from RCUK and the British Pharmacological Society Integrative Pharmacology Fund. JPR is funded by the Wellcome Trust and previously received support from the Medical Research Council.

JPR is a consultant for Cambridge Cognition.

References

  1. Abramson LY, Seligman ME, Teasdale JD (1978) Learned helplessness in humans: critique and reformulation. J Abnorm Psychol 87:49–74PubMedCrossRefGoogle Scholar
  2. Agid Y, Buzsaki G, Diamond DM, Frackowiak R, Giedd J, Girault JA, Grace A, Lambert JJ, Manji H, Mayberg H, Popoli M, Prochiantz A, Richter-Levin G, Somogyi P, Spedding M, Svenningsson P, Weinberger D (2007) How can drug discovery for psychiatric disorders be improved? Nat Rev Drug Discov 6:189–201PubMedCrossRefGoogle Scholar
  3. American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Publishing, Arlington, VACrossRefGoogle Scholar
  4. Amitai N, Young J, Higa K, Sharp R, Geyer M, Powell S (2013). Isolation rearing effects on probabilistic learning and cognitive flexibility in rats. Cogn Affect Behav Neurosci 1–19Google Scholar
  5. Anderson MH, Munafò M, Robinson EJ (2013) Investigating the psychopharmacology of cognitive affective bias in rats using an affective tone discrimination task. Psychopharmacology 226:601–613PubMedCrossRefGoogle Scholar
  6. Austin MP, Mitchell P, Goodwin GM (2001) Cognitive deficits in depression: possible implications for functional neuropathology. Br J Psychiatry 178:200–206PubMedCrossRefGoogle Scholar
  7. Bari A, Theobald DE, Caprioli D, Mar AC, Aidoo-Micah A, Dalley JW et al (2010) Serotonin modulates sensitivity to reward and negative feedback in a probabilistic reversal learning task in rats. Neuropsychopharmacology 35:1290–1301PubMedPubMedCentralCrossRefGoogle Scholar
  8. Bateson M, Desire S, Gartside SE, Wright GA (2011) Agitated honeybees exhibit pessimistic cognitive biases. Curr Biol 21:1070–1073PubMedPubMedCentralCrossRefGoogle Scholar
  9. Beats BC, Sahakian BJ, Levy R (1996) Cognitive performance in tests sensitive to frontal lobe dysfunction in the elderly depressed. Psychol Med 26:591–603PubMedCrossRefGoogle Scholar
  10. Beck AT (1967) Depression: clinical, experimental and theoretical aspects. Harper & Row, New YorkGoogle Scholar
  11. Berlin I, Givry-Steiner L, Lecrubier Y, Puech AJ (1998) Measures of anhedonia and hedonic responses to sucrose in depressive and schizophrenic patients in comparison with healthy subjects. Eur J Psychaitry 13:303–309CrossRefGoogle Scholar
  12. Berton O, Hahn CG, Thase ME (2012) Are we getting closer to valid translational models for major depression? Science 338:75–79PubMedCrossRefGoogle Scholar
  13. Bhagwagar Z, Cowen PJ, Goodwin GM, Harmer CJ (2004) Normalization of enhanced fear recognition by acute SSRI treatment in subjects with a previous history of depression. Am J Psychiatry 161:166–168PubMedCrossRefGoogle Scholar
  14. Booij L, Van der Does AJ, Haffmans PM, Riedel WJ, Fekkes D, Blom MJ (2005) The effects of high-dose and low-dose tryptophan depletion on mood and cognitive functions of remitted depressed patients. J Psychopharmacol 19:267–275PubMedCrossRefGoogle Scholar
  15. Burman OHP, Parker R, Paul ES, Mendl M (2008) A spatial judgement task to determine background emotional state in laboratory rats, Rattus norvegicus. Anim Behav 76:801–809CrossRefGoogle Scholar
  16. Bussey TJ, Holmes A, Lyon L, Mar AC, McAllister KA, Nithianantharajah J, Oomen CA, Saksida LM (2012) New translational assays for pre-clinical modelling of cognition in schizophrenia: the touchscreen testing method for mice and rats. Neuropharmacology 62(3):1191–1203PubMedCrossRefGoogle Scholar
  17. Clark L, Chamberlain SR, Sahakian BJ (2009) Neurocognitive mechanisms in depression: implications for treatment. Annu Rev Neurosci 32:57–74PubMedCrossRefGoogle Scholar
  18. Chase HW, Frank MJ, Michael A, Bullmore ET, Sahakian BJ, Robbins TW (2010) Approach and avoidance learning in patients with major depression and healthy controls: relation to anhedonia. Psychol Med 40:433–440PubMedCrossRefGoogle Scholar
  19. Cools R, Blackwell A, Clark L, Menzies L, Cox S, Robbins TW (2005) Tryptophan depletion disrupts the motivational guidance of goal-directed behavior as a function of trait impulsivity. Neuropsychopharmacology 30:1362–1373PubMedGoogle Scholar
  20. Cryan JF, Slattery DA (2007) Animal models of mood disorders: recent developments. Curr Opin Psychiatry 20:1–7PubMedCrossRefGoogle Scholar
  21. Cryan JF, Mombereau C, Vassout A (2005) The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. Neurosci Biobehav Rev 29:571–625PubMedCrossRefGoogle Scholar
  22. Delgado PL, Charney DS, Price LH, Aghajanian GK, Landis H, Heninger GR (1990) Serotonin function and the mechanism of antidepressant action. Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan. Arch Gen Psychiatry 47:411–418PubMedCrossRefGoogle Scholar
  23. Detke MJ, Rickels M, Lucki I (1995) Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Psychopharmacology 121:66–72PubMedCrossRefGoogle Scholar
  24. Dichter GS, Smoski MJ, Kampov-Polevoy AB, Gallop R, Garbutt JC (2012) Unipolar depression does not moderate responses to the Sweet Taste Test. Depress Anxiety 27:859–863CrossRefGoogle Scholar
  25. Dickstein DP, Finger EC, Brotman MA, Rich BA, Pine DS, Blair JR, Leibenluft E (2009) Impaired probabilistic reversal learning in youths with mood and anxiety disorders. Psychol Med 40(7):1089–1100PubMedPubMedCentralCrossRefGoogle Scholar
  26. Dinan TG (1994) Glucocorticoids and the genesis of depressive illness. A psychobiological model. Br J Psychiatry 164:365–371PubMedCrossRefGoogle Scholar
  27. Elliott R, Sahakian BJ, Herrod JJ, Robbins TW, Paykel ES (1997) Abnormal response to negative feedback in unipolar depression: evidence for a diagnosis specific impairment. J Neurol Neurosurg Psychiatry 63:74–82PubMedPubMedCentralCrossRefGoogle Scholar
  28. Elliott R, Sahakian BJ, McKay AP, Herrod JJ, Robbins TW, Paykel ES (1996) Neuropsychological impairments in unipolar depression: the influence of perceived failure on subsequent performance. Psychol Med 26:975–989PubMedCrossRefGoogle Scholar
  29. Elliott R, Zahn R, Deakin JF, Anderson IM (2011) Affective cognition and its disruption in mood disorders. Neuropsychopharmacology 36:153–182PubMedCrossRefGoogle Scholar
  30. Enkel T, Gholizadeh D, von Bohlen Und Halbach O, Sanchis-Segura C, Hurlemann R, Spanagel R et al. (2010). Ambiguous-cue interpretation is biased under stress- and depression-like states in rats. Neuropsychopharmacology 35:1008–1015Google Scholar
  31. Erickson K, Drevets WC, Clark L, Cannon DM, Bain EE, Zarate CA Jr, Charney DS, Sahakian BJ (2005) Mood-congruent bias in affective go/no-go performance of unmedicated patients with major depressive disorder. Am J Psychiatry 162:2171–2173PubMedCrossRefGoogle Scholar
  32. Eshel N, Roiser JP (2010) Reward and punishment processing in depression. Biol Psychiatry 68(2):118–124PubMedCrossRefGoogle Scholar
  33. Firk C, Markus CR (2008) Effects of acute tryptophan depletion on affective processing in first-degree relatives of depressive patients and controls after exposure to uncontrollable stress. Psychopharmacology 199:151–160PubMedPubMedCentralCrossRefGoogle Scholar
  34. Fournier JC, DeRubeis RJ, Hollon SD, Dimidjian S, Amsterdam JD, Shelton RC, Fawcett J (2010) Antidepressant drug effects and depression severity: a patient-level meta-analysis. JAMA 303:47–53PubMedPubMedCentralCrossRefGoogle Scholar
  35. Geyer M, Markou A (1995) Animal models of psychiatric disorders. In: Bloom F, Kupfer D (eds) Psychopharmacology: the fourth generation of progress. Raven Press, New York, pp 787–798Google Scholar
  36. Gorwood P (2008) Neurobiological mechanisms of anhedonia. Dialogues Clin Neurosci 10(3):291–299PubMedPubMedCentralGoogle Scholar
  37. Gotlib IH, Joormann J (2010) Cognition and depression: current status and future directions. Annu Rev Clin Psychol 6:285–312PubMedPubMedCentralCrossRefGoogle Scholar
  38. Gourley SL, Kiraly DD, Howell JL, Olausson P, Taylor JR (2008) Acute hippocampal brain-derived neurotrophic factor restores motivational and forced swim performance after corticosterone. Biol Psychiatry 64(10):884–890PubMedPubMedCentralCrossRefGoogle Scholar
  39. Hales CA, Stuart SA, Anderson MH, Robinson ES (2014) Modelling cognitive affective biases in major depressive disorder using rodents. Br J Pharmacol 171(20):4524–4538PubMedPubMedCentralCrossRefGoogle Scholar
  40. Harding EJ, Paul ES, Mendl M (2004) Animal behaviour: cognitive bias and affective state. Nature 427:312PubMedCrossRefGoogle Scholar
  41. Harmer CJ (2008) Serotonin and emotional processing: does it help explain antidepressant drug action? Neuropharmacology 55:1023–1028PubMedCrossRefGoogle Scholar
  42. Harmer CJ, Goodwin GM, Cowen PJ (2009a) Why do antidepressants take so long to work? A cognitive neuropsychological model of antidepressant drug action. Br J Psychiatry 195:102–108PubMedCrossRefGoogle Scholar
  43. Harmer CJ, Hill SA, Taylor MJ, Cowen PJ, Goodwin GM (2003) Toward a neuropsychological theory of antidepressant drug action: increase in positive emotional bias after potentiation of norepinephrine activity. Am J Psychiatry 160:990–992PubMedCrossRefGoogle Scholar
  44. Harmer CJ, O’Sullivan U, Favaron E, Massey-Chase R, Ayres R, Reinecke A, Goodwin GM, Cowen PJ (2009b) Effect of acute antidepressant administration on negative affective bias in depressed patients. Am J Psychiatry 166:1178–1184PubMedCrossRefGoogle Scholar
  45. Harmer CJ, Shelley NC, Cowen PJ, Goodwin GM (2004) Increased positive versus negative affective perception and memory in healthy volunteers following selective serotonin and norepinephrine reuptake inhibition. Am J Psychiatry 161:1256–1263PubMedCrossRefGoogle Scholar
  46. Hasler G, Luckenbaugh DA, Snow J, Meyers N, Waldeck T, Geraci M, Roiser J, Knutson B, Charney DS, Drevets WC (2009a) Reward processing after catecholamine depletion in unmedicated, remitted subjects with major depressive disorder. Biol Psychiatry 66:201–205PubMedPubMedCentralCrossRefGoogle Scholar
  47. Hasler G, Mondillo K, Drevets WC, Blair JR (2009b) Impairments of probabilistic response reversal and passive avoidance following catecholamine depletion. Neuropsychopharmacology 34(13):2691–2698PubMedPubMedCentralCrossRefGoogle Scholar
  48. Hayward G, Goodwin GM, Cowen PJ, Harmer CJ (2005) Low-dose tryptophan depletion in recovered depressed patients induces changes in cognitive processing without depressive symptoms. Biol Psychiatry 57:517–524PubMedCrossRefGoogle Scholar
  49. Henn FA, Vollmayr B (2005) Stress models of depression: forming genetically vulnerable strains. Neurosci Biobehav Rev 29(4–5):799–804PubMedCrossRefGoogle Scholar
  50. Henriques JB, Davidson RJ (2000) Decreased responsiveness to reward in depression. Cogn Emot 14:711–724CrossRefGoogle Scholar
  51. Henriques JB, Glowacki JM, Davidson RJ (1994) Reward fails to alter response bias in depression. J Abnorm Psychol 103:460–466PubMedCrossRefGoogle Scholar
  52. Hollon SD, DeRubeis RJ, Fawcett J, Amsterdam JD, Shelton RC, Zajecka J, Young PR, Gallop R (2014) Effect of cognitive therapy with antidepressant medications vs antidepressants alone on the rate of recovery in major depressive disorder: a randomized clinical trial. JAMA Psychiatry 71:1157–1164PubMedPubMedCentralCrossRefGoogle Scholar
  53. Huys QJ, Daw ND, Dayan P (2015) Depression: a decision-theoretic analysis. Annu Rev NeurosciGoogle Scholar
  54. Ineichen C, Sigrist H, Spinelli S, Lesch KP, Sautter E, Seifritz E, Pryce CR (2012) Establishing a probabilistic reversal learning test in mice: evidence for the processes mediating reward-stay and punishment-shift behaviour and for their modulation by serotonin. Neuropharmacology 63(6):1012–1021PubMedCrossRefGoogle Scholar
  55. Joormann J, Gotlib IH (2006) Is this happiness I see? Biases in the identification of emotional facial expressions in depression and social phobia. J Abnorm Psychol 115:705–714PubMedCrossRefGoogle Scholar
  56. Joormann J, Gotlib IH (2008) Updating the contents of working memory in depression: interference from irrelevant negative material. J Abnorm Psychol 117:182–192PubMedCrossRefGoogle Scholar
  57. Kohler S, Unger T, Hoffmann S, Mackert A, Ross B, Fydrich T (2015) Dysfunctional cognitions of depressive inpatients and their relationship with treatment outcome. Compr Psychiatry 58:50–56PubMedCrossRefGoogle Scholar
  58. Leventopoulos M, Russig H, Feldon J, Pryce CR, Opacka-Juffry J (2009) Early deprivation leads to long-term reductions in motivation for reward and 5-HT1A binding and both effects are reversed by fluoxetine. Neuropharmacology 56(3):692–701PubMedCrossRefGoogle Scholar
  59. Maier SF (1984) Learned helplessness and animal models of depression. Prog Neuropsychopharmacol Biol Psychiatry 8(3):435–446PubMedCrossRefGoogle Scholar
  60. Mathews A, MacLeod C (2005) Cognitive vulnerability to emotional disorders. Annu Rev Clin Psychol 1:167–195PubMedCrossRefGoogle Scholar
  61. Matt GE, Vazquez C, Campbell WK (1992) Mood-congruent recall of affectively toned stimuli—a meta- analytic review. Clin Psychol Rev 12:227–255CrossRefGoogle Scholar
  62. McArthur R, Borsini F (2006) Animal models of depression in drug discovery: a historical perspective. Pharmacol Biochem Behav 84:436–452PubMedCrossRefGoogle Scholar
  63. McCabe C, Cowen PJ, Harmer CJ (2009) Neural representation of reward in recovered depressed patients. Psychopharmacology 205:667–677PubMedPubMedCentralCrossRefGoogle Scholar
  64. McLean A, Rubinsztein JS, Robbins TW, Sahakian BJ (2004) The effects of tyrosine depletion in normal healthy volunteers: implications for unipolar depression. Psychopharmacology 171:286–297PubMedCrossRefGoogle Scholar
  65. McGuire PS, Seiden LS (1980) Differential effects of imipramine in rats as a function of DRL schedule value. Pharmacol Biochem Behav 13(5):691–694PubMedCrossRefGoogle Scholar
  66. Mendl M, Burman OHP, Paul ES (2010) An integrative and functional framework for the study of animal emotion and mood. Proc Roy Soc B Biol Sci 277:2895–2904CrossRefGoogle Scholar
  67. Mendl M, Paul ES, Chittka L (2011) Animal behaviour: emotion in invertebrates? Curr Biol 21:R463–R465PubMedCrossRefGoogle Scholar
  68. Munafo MR, Hayward G, Harmer C (2006) Selective processing of social threat cues following acute tryptophan depletion. J Psychopharmacol 20:33–39PubMedCrossRefGoogle Scholar
  69. Murphy FC, Michael A, Robbins TW, Sahakian BJ (2003) Neuropsychological impairment in patients with major depressive disorder: the effects of feedback on task performance. Psychol Med 33:455–467PubMedCrossRefGoogle Scholar
  70. Murphy FC, Rubinsztein JS, Michael A, Rogers RD, Robbins TW, Paykel ES, Sahakian BJ (2001) Decision-making cognition in mania and depression. Psychol Med 31:679–693PubMedCrossRefGoogle Scholar
  71. Murphy FC, Sahakian BJ, Rubinsztein JS, Michael A, Rogers RD, Robbins TW, Paykel ES (1999) Emotional bias and inhibitory control processes in mania and depression. Psychol Med 29:1307–1321PubMedCrossRefGoogle Scholar
  72. Murphy FC, Smith KA, Cowen PJ, Robbins TW, Sahakian BJ (2002) The effects of tryptophan depletion on cognitive and affective processing in healthy volunteers. Psychopharmacology 163:42–53PubMedCrossRefGoogle Scholar
  73. Murphy SE, Longhitano C, Ayres RE, Cowen PJ, Harmer CJ (2006) Tryptophan supplementation induces a positive bias in the processing of emotional material in healthy female volunteers. Psychopharmacology 187:121–130PubMedCrossRefGoogle Scholar
  74. Nestler EJ, Hyman SE (2010) Animal models of neuropsychiatric disorders. Nat Neurosci 13:1161–1169PubMedPubMedCentralCrossRefGoogle Scholar
  75. O’Leary OF, Cryan JF (2013) Towards translational rodent models of depression. Cell Tissue Res 354:141–153PubMedCrossRefGoogle Scholar
  76. Olausson P, Kiraly DD, Gourley SL, Taylor JR (2013) Persistent effects of prior chronic exposure to corticosterone on reward-related learning and motivation in rodents. Psychopharmacology 225(3):569–577PubMedCrossRefGoogle Scholar
  77. Overmier JB, Seligman ME (1967) Effects of inescapable shock upon subsequent escape and avoidance responding. J Comp Physiol Psychol. 63:28–33PubMedCrossRefGoogle Scholar
  78. Papciak J, Popik P, Fuchs E, Rygula R (2013) Chronic psychosocial stress makes rats more ‘pessimistic’ in the ambiguous-cue interpretation paradigm. Behav Brain Res 256:305–310PubMedCrossRefGoogle Scholar
  79. Paul ES, Harding EJ, Mendl M (2005) Measuring emotional processes in animals: the utility of a cognitive approach. Neurosci Biobehav Rev 29:469–491PubMedCrossRefGoogle Scholar
  80. Pizzagalli DA, Goetz E, Ostacher M, Iosifescu DV, Perlis RH (2008a) Euthymic patients with bipolar disorder show decreased reward learning in a probabilistic reward task. Biol Psychiatry 64:162–168PubMedPubMedCentralCrossRefGoogle Scholar
  81. Pizzagalli DA, Iosifescu D, Hallett LA, Ratner KG, Fava M (2008b) Reduced hedonic capacity in major depressive disorder: evidence from a probabilistic reward task. J Psychiatr Res 43:76–87PubMedPubMedCentralCrossRefGoogle Scholar
  82. Pollak DD, Rey CE, Monje FJ (2010) Rodent models in depression research: classical strategies and new directions. Ann Med 42:252–264PubMedCrossRefGoogle Scholar
  83. Porsolt RD, Le Pichon M, Jalfre M (1977) Depression: a new animal model sensitive to antidepressant treatments. Nature 266:730–732PubMedCrossRefGoogle Scholar
  84. Pringle A, Browning M, Cowen PJ, Harmer CJ (2011) A cognitive neuropsychological model of antidepressant drug action. Prog Neuropsychopharmacol Biol Psychiatry 35:1586–1592PubMedCrossRefGoogle Scholar
  85. Pryce CR, Azzinnari D, Spinelli S, Seifritz E, Tegethoff M, Meinlschmidt G (2011) Helplessness: a systematic translational review of theory and evidence for its relevance to understanding and treating depression. Pharmacol Ther 132(3):242–267PubMedCrossRefGoogle Scholar
  86. Rawal A, Collishaw S, Thapar A, Rice F (2013) ‘The risks of playing it safe’: a prospective longitudinal study of response to reward in the adolescent offspring of depressed parents. Psychol Med 43:27–38PubMedCrossRefGoogle Scholar
  87. Richter SH, Schick A, Hoyer C, Lankisch K, Gass P, Vollmayr B (2012) A glass full of optimism: enrichment effects on cognitive bias in a rat model of depression. Cogn Affect Behav Neurosci 12:527–542PubMedCrossRefGoogle Scholar
  88. Riedel M, Moller HJ, Obermeier M, Adli M, Bauer M, Kronmuller K, Brieger P, Laux G, Bender W, Heuser I, Zeiler J, Gaebel W, Schennach-Wolff R, Henkel V, Seemuller F (2011) Clinical predictors of response and remission in inpatients with depressive syndromes. J Affect Disord 133:137–149PubMedCrossRefGoogle Scholar
  89. Robinson OJ, Cools R, Sahakian BJ (2011) Tryptophan depletion disinhibits punishment but not reward prediction: implications for resilience. Psychopharmacology (Berl) 2:599–605Google Scholar
  90. Rock PL, Roiser JP, Riedel WJ, Blackwell AD (2013) Cognitive impairment in depression: a systematic review and meta-analysis. Psychol Med 1–12Google Scholar
  91. Rogers RD, Tunbridge EM, Bhagwagar Z, Drevets WC, Sahakian BJ, Carter CS (2003) Tryptophan depletion alters the decision-making of healthy volunteers through altered processing of reward cues. Neuropsychopharmacology 28:153–162PubMedCrossRefGoogle Scholar
  92. Roiser JP, Blackwell AD, Cools R, Clark L, Rubinsztein DC, Robbins TW, Sahakian BJ (2006) Serotonin transporter polymorphism mediates vulnerability to loss of incentive motivation following acute tryptophan depletion. Neuropsychopharmacology 31:2264–2272PubMedPubMedCentralCrossRefGoogle Scholar
  93. Roiser JP, Cannon DM, Gandhi SK, Tavares JT, Erickson K, Wood S, Klaver JM, Clark L, Zarate CA Jr, Sahakian BJ, Drevets WC (2009) Hot and cold cognition in unmedicated depressed subjects with bipolar disorder. Bipolar Disord 11:178–189PubMedPubMedCentralCrossRefGoogle Scholar
  94. Roiser JP, Elliott R, Sahakian BJ (2012) Cognitive mechanisms of treatment in depression. Neuropsychopharmacology 37:117–136PubMedCrossRefGoogle Scholar
  95. Roiser JP, Levy J, Fromm SJ, Wang H, Hasler G, Sahakian BJ, Drevets WC (2008) The effect of acute tryptophan depletion on the neural correlates of emotional processing in healthy volunteers. Neuropsychopharmacology 33:1992–2006PubMedCrossRefGoogle Scholar
  96. Roiser JP, McLean A, Ogilvie AD, Blackwell AD, Bamber DJ, Goodyer I, Jones PB, Sahakian BJ (2005) The subjective and cognitive effects of acute phenylalanine and tyrosine depletion in patients recovered from depression. Neuropsychopharmacology 30:775–785PubMedPubMedCentralGoogle Scholar
  97. Roiser JP, Sahakian BJ (2013) Hot and cold cognition in depression. CNS Spectr 18:139–149PubMedCrossRefGoogle Scholar
  98. Rüedi-Bettschen D, Pedersen EM, Feldon J, Pryce CR (2005) Early deprivation under specific conditions leads to reduced interest in reward in adulthood in Wistar rats. Behav Brain Res 156(2):297–310PubMedCrossRefGoogle Scholar
  99. Ruhe HG, Mason NS, Schene AH (2007) Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies. Molecular Psychiatry 12:331–359PubMedCrossRefGoogle Scholar
  100. Rygula R, Papciak J, Popik P (2013) Trait pessimism predicts vulnerability to stress-induced anhedonia in rats. Neuropsychopharmacology 38:2188–2196PubMedPubMedCentralCrossRefGoogle Scholar
  101. Rygula R, Papciak J, Popik P (2014) The effects of acute pharmacological stimulation of the 5-HT, NA and DA systems on the cognitive judgement bias of rats in the ambiguous-cue interpretation paradigm. Eur Neuropsychopharmacol 24(7):1103–1111PubMedCrossRefGoogle Scholar
  102. Savitz J, Lucki I, Drevets WC (2009) 5-HT(1A) receptor function in major depressive disorder. Prog Neurobiol 88:17–31PubMedPubMedCentralCrossRefGoogle Scholar
  103. Seiden LS, Dahms JL, Shaughnessy RA (1985) Behavioral screen for antidepressants: the effects of drugs and electroconvulsive shock on performance under a differential-reinforcement-of-low-rate schedule. Psychopharmacology 86(1–2):55–60PubMedCrossRefGoogle Scholar
  104. Seligman ME, Beagley G (1975) Learned helplessness in the rat. J Comp Physiol Psychol 88(2):534–541PubMedCrossRefGoogle Scholar
  105. Smith KA, Fairburn CG, Cowen PJ (1997) Relapse of depression after rapid depletion of tryptophan. Lancet 349:915–919PubMedCrossRefGoogle Scholar
  106. Snyder HR (2012) Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: a meta-analysis and review. Psychol Bull 139:81Google Scholar
  107. Steru L, Chermat R, Thierry B, Simo P (1985) The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology 85:367–370PubMedCrossRefGoogle Scholar
  108. Stuart SA, Butler P, Munafò MR, Nutt DJ, Robinson ESJ (2013) A translational rodent assay of affective biases in depression and antidepressant therapy. Neuropsychopharmacology 38:1625–1635PubMedPubMedCentralCrossRefGoogle Scholar
  109. Stuart SA, Butler P, Munafò MR, Nutt DJ, Robinson ESJ (2015) Distinct neuropsychological mechanisms may explain delayed-versus rapid-onset antidepressant efficacy. Neuropsychopharmacology. doi: 10.1038/npp.2015.59PubMedPubMedCentralGoogle Scholar
  110. Taylor Tavares JV, Clark L, Furey ML, Williams GB, Sahakian BJ, Drevets WC (2008) Neural basis of abnormal response to negative feedback in unmedicated mood disorders. Neuroimage 42:1118–1126PubMedPubMedCentralCrossRefGoogle Scholar
  111. Teachman BA, Joormann J, Steinman SA, Gotlib IH (2012) Automaticity in anxiety disorders and major depressive disorder. Clin Psychol Rev 32:575–603PubMedPubMedCentralCrossRefGoogle Scholar
  112. Tranter R, Bell D, Gutting P, Harmer C, Healy D, Anderson IM (2009) The effect of serotonergic and noradrenergic antidepressants on face emotion processing in depressed patients. J Affect Disord 118:87–93PubMedCrossRefGoogle Scholar
  113. Treadway MT, Bossaller NA, Shelton RC, Zald DH (2012) Effort-based decision-making in major depressive disorder: a translational model of motivational anhedonia. J Abnorm Psychol 121:553–558PubMedPubMedCentralCrossRefGoogle Scholar
  114. Treadway MT, Zald DH (2011) Reconsidering anhedonia in depression: lessons from translational neuroscience. Neurosci Biobehav Rev 35:537–555PubMedCrossRefGoogle Scholar
  115. Trivedi MH, Rush AJ, Wisniewski SR, Nierenberg AA, Warden D, Ritz L, Norquist G, Howland RH, Lebowitz B, McGrath PJ, Shores-Wilson K, Biggs MM, Balasubramani GK, Fava M (2006) Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice. Am J Psychiatry 163:28–40PubMedCrossRefGoogle Scholar
  116. Vogel GW, Minter K, Woolwine B (1986) Effects of chronically administered antidepressant drugs on animal behavior. Physiol Behav 36:659–666PubMedCrossRefGoogle Scholar
  117. Vollmayr B, Bachteler D, Vengeliene V, Gass P, Spanagel R, Henn F (2004) Rats with congenital learned helplessness respond less to sucrose but show no deficits in activity or learning. Behav Brain Res 150(1–2):217–221PubMedCrossRefGoogle Scholar
  118. Vrieze E, Pizzagalli DA, Demyttenaere K, Hompes T, Sienaert P, de Boer P, Schmidt M, Claes S (2013) Reduced reward learning predicts outcome in major depressive disorder. Biol Psychiatry 73:639–645PubMedCrossRefGoogle Scholar
  119. Willner P, Towell A, Sampson D, Sophokleous S, Muscat R (1987) Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacology 93:358–364PubMedCrossRefGoogle Scholar
  120. Wittchen HU, Jacobi F, Rehm J, Gustavsson A, Svensson M, Jonsson B, Olesen J, Allgulander C, Alonso J, Faravelli C, Fratiglioni L, Jennum P, Lieb R, Maercker A, van Os J, Preisig M, Salvador-Carulla L, Simon R, Steinhausen HC (2011) The size and burden of mental disorders and other disorders of the brain in Europe 2010. Eur Neuropsychopharmacol 21:655–679PubMedCrossRefGoogle Scholar
  121. Wright WF, Bower GH (1992) Mood effects on subjective probability assessment. Organ Behav Hum Decis Process 52:276–291CrossRefGoogle Scholar
  122. Zacharko RM, Anisman H (1991) Stressor-induced anhedonia in the mesocorticolimbic system. Neurosci Biobehav Rev 15:391–405PubMedCrossRefGoogle Scholar

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© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.School of Physiology and Pharmacology, Medical Sciences BuildingUniversity WalkBristolUK
  2. 2.Institute of Cognitive NeuroscienceUniversity College LondonLondonUK

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