What Can Fear and Reward Learning Teach Us About Depression?

  • Katherine A. Collins
  • Daniela SchillerEmail author
Part of the Current Topics in Behavioral Neurosciences book series (CTBN, volume 14)


The precise neural substrates of major depressive disorder (MDD) remain elusive, and FDA-approved antidepressants fail at least one-third of treatment-seeking patients. It is imperative, therefore, to identify novel research strategies to tackle the factors impeding progress. In this chapter we propose that the knowledge derived from computational investigations of associative learning might offer new insights into the neurobiology of MDD.


Associative learning Reward learning Fear learning/conditioning Prediction error Major Depressive Disorder (Mdd) 


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© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Mt. Sinai School of MedicineNew YorkUS

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