ADHD: Volumetry, Motor, and Oculomotor Functions

Chapter
Part of the Current Topics in Behavioral Neurosciences book series (CTBN, volume 9)

Abstract

The use of quantitative neuroimaging (volumetry), motor, and oculomotor assessments for studying children with attention-deficit/hyperactivity disorder (ADHD) has grown dramatically in the past 20 years. Most evidence to date suggests that anomalous basal ganglia development plays an important role in early manifestation of ADHD; however, widespread cerebellar and cortical delays are also observed and are associated with the behavioral (cognitive, motor, oculomotor) phenotype in children with ADHD. These motor and “executive” control systems appear to develop in parallel, such that both systems display a similar protracted developmental trajectory, with periods of rapid growth in elementary years and continued maturation into young adulthood. Development of each system is dependent on the functional integrity and maturation of related brain regions, suggesting a shared neural circuitry that includes frontostriatal systems and the cerebellum (i.e., those identified as anomalous in studies of volumetry in ADHD). Motor and oculomotor paradigms provide unique opportunities to examine executive control processes that exist at the interface between movement and cognition in children with ADHD, also linking cognition and neurological development. The observed pattern of volumetric differences, together with the known parallel development of motor and executive control systems, appears to predict motor and oculomotor anomalies in ADHD, which are highly relevant, yet commonly overlooked in clinical settings.

Keywords

Attention Childhood Executive function MRI Saccade Sensorimotor Volume 

Abbreviations

ADHD

Attention-deficit/hyperactivity disorder

aMRI

Anatomic (MRI)

DAMP

Deficits in attention motor control, and perception

DAT

Dopamine transporter

DCD

Developmental coordination disorder

DRD1/DRD4

Dopamine receptor (D1 or D4 subtype)

LDDMM

Large deformation diffeomorphic metric mapping

MABC

Motor Assessment Battery for Children

MFNA

Motor Function Neurological Assessment (MFNU)

MGS

Memory-guided saccades

MRI

Magnetic resonance imaging

ODD

Oppositional defiant disorder

SMC

Supplementary motor complex

TMS

Transcranial magnetic stimulation

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© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Kennedy Krieger InstituteJohns Hopkins University School of MedicineBaltimoreUSA

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