Dopamine-Based Reward Circuitry Responsivity, Genetics, and Overeating


Data suggest that low levels of dopamine D2 receptors and attenuated responsivity of dopamine-target regions to food intake is associated with increased eating and elevated weight. There is also growing (although mixed) evidence that genotypes that appear to lead to reduced dopamine signaling (e.g., DRD2, DRD4, and DAT) and certain appetite-related hormones and peptides (e.g., ghrelin, orexin A, leptin) moderate the relation between dopamine signaling, overeating, and obesity. This chapter reviews findings from studies that have investigated the relation between dopamine functioning and food intake and how certain genotypes and appetite-related hormones and peptides affect this relation.


Dopamine Food reward Genetics Overeating Obesity 

Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Eric Stice
    • 1
  • Sonja Yokum
    • 1
  • David Zald
    • 2
  • Alain Dagher
    • 3
  1. 1.Oregon Research InstituteEugeneUSA
  2. 2.Vanderbilt UniversityNashvilleUSA
  3. 3.McGill UniversityMontrealCanada

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