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Prefrontal Cortical Regulation of Drug Seeking in Animal Models of Drug Relapse

  • Heather C. Lasseter
  • Xiaohu Xie
  • Donna R. Ramirez
  • Rita A. FuchsEmail author
Chapter
Part of the Current Topics in Behavioral Neurosciences book series (CTBN, volume 3)

Abstract

Prefrontal cortical dysfunction is thought to underlie maladaptive behaviors displayed by chronic drug users, most notably the high propensity for relapse that severely impedes successful treatment of drug addiction. In animal models of drug relapse, exposure to drug-associated stimuli, small amounts of drug, and acute stressors powerfully reinstate drug seeking by critically engaging the prefrontal cortex, with the anterior cingulate, prelimbic, infralimbic, and orbitofrontal subregions making distinct contributions to drug seeking. Hence, from an addiction treatment perspective, it is necessary to fully explicate the involvement of the prefrontal cortex in drug relapse.

Keywords

Anterior cingulate Drug seeking Extinction Infralimbic Orbitofrontal Prefrontal cortex Prelimbic Reinstatement 

Abbreviations

ACC

Anterior cingulate cortex

AMPA

Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

BDNF

Brain derived neurotrophic factor

BLA

Basolateral amygdala

BM

Baclofen and muscimol

BNST

Bed nucleus of the stria terminalis

CeA

Central amygdaloid nucleus

CS

Conditioned stimulus

DH

Dorsal hippocampus

dlCPu

Dorsolateral caudate-putamen

GABA

Gamma-aminobutyric acid

IL

Infralimbic cortex

LTN

Lateral tegmental nucleus

NA

Nucleus accumbens

NAcore

Core region of the nucleus accumbens

NAshell

Shell region of the nucleus accumbens

NBm

Nucleus basalis of Mynert

OFC

Orbitofrontal cortex

p-ERK

Phospho-extracellular-related kinase

PL

Prelimbic cortex

RGS4

Regulator of G-protein signaling 4

TTX

Tetrodotoxin

VH

Ventral hippocampus

VP

Ventral pallidum

VTA

Ventral tegmental area

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Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Heather C. Lasseter
    • 1
  • Xiaohu Xie
    • 1
  • Donna R. Ramirez
    • 1
  • Rita A. Fuchs
    • 1
    Email author
  1. 1.Department of PsychologyUniversity of North CarolinaChapel HillUSA

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