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Bdellovibrio and Like Organisms: Potential Sources for New Biochemicals and Therapeutic Agents?

  • Eckhard Strauch
  • Sebastian Beck
  • Bernd Appel
Chapter
Part of the Microbiology Monographs book series (MICROMONO, volume 4)

Abstract

Bdellovibrio and like organisms (BALOs) are predatory bacteria capable of invading the periplasm of Gram-negative bacteria and of growing and replicating within this protected niche. Research dedicated to studying the sophisticated weaponry of these predators aims to find novel strategies for combating pathogenic bacteria as the worldwide increase of pathogens resistant to a wide range of antibiotics forces a search for alternative antimicrobial substances to counter this threat. The physiology of BALOs will be the main focus of this chapter, and some potential applications for BALOs will be discussed. However, our current knowledge of the amazing biology of these extraordinary prokaryotes that possess an astonishing predatory lifestyle and perform a well-organized deconstruction of prey bacteria is still rather limited. The great advances in proteomic and genomic techniques will allow the investigation of the interaction between predators and prey, lately supported by the availability of the genome sequence of one B. bacteriovorus reference strain. It seems likely that the exploitation of the unique weaponry of these bacteria will enable researchers to find new biochemicals and—perhaps—therapeutic agents.

Keywords

Outer Membrane Protein Bacteriophage Therapy Intracellular Growth Prey Location Prey Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  1. 1.Bundesinstitut für Risikobewertung (BfR)Federal Institute for Risk AssessmentBerlinGermany

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