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Dioxins and Dioxin-Like Compounds in Food and Feed

  • Martin RoseEmail author
Chapter
Part of the The Handbook of Environmental Chemistry book series (HEC, volume 49)

Abstract

Dioxins (PCDD/Fs) and polychlorinated biphenyls (PCBs) are environmentally persistent organic pollutants (POPs) that are associated with human health effects. These substances persist for long periods of time in the environment and accumulate and pass from one species to the next through the food chain. Human exposure to POPs is mainly through contaminated foods, and certain cultures or individuals whose diets include large amounts of fish or wild foods that are high in fat are particularly at risk of high exposure. In addition to the PCDD/Fs and PCBs, several other classes of contaminants behave similarly and share some common environmental fate and toxicological characteristics. These include well-known legacy contaminants such as DDT and certain chlorinated pesticides, as well as several new or emerging classes of persistent, bioaccumulative and toxic (PBT) substances. To make reliable estimates of human dietary exposure, it is important to have a robust sampling and analysis methodology and have sound knowledge about dietary preferences and food consumption patterns. In general, the highest levels of dioxins, PCBs and other PBTs are typically found globally in the fatty tissues and livers of fish and wildlife that occupy higher tropic levels in aquatic and terrestrial food chains. Toddlers and young children are typically at risk of higher exposure than adults because of their lower body weights and relatively higher food intakes. Dioxin and PCB levels in the food supply are generally decreasing, but high levels persist in some regions due to legacy contamination from industrial activity, the consequences of wartime use of defoliants, global cycling to the northern polar regions and isolated food contamination incidents. There is evidence, however, that exposure to new or emerging PBTs with dioxin-like characteristics such as certain brominated substances could be increasing in importance.

Keywords

Dietary exposure Dioxins Feed Food Food intake PBTs 

References

  1. 1.
    Van den Berg M, Birnbaum LS, Denison M, De Vito M, Farland W, Feeley M, Fiedler H, Hakansson H, Hanberg A, Haws L, Rose M, Safe S, Schrenk D, Tohyama C, Tritscher A, Tuomisto J, Tysklind M, Walker N, Peterson RE (2006) The 2005 World Health Organization reevaluation of human and mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicol Sci 93(2):223–241. doi: 10.1093/toxsci/kfl055 CrossRefGoogle Scholar
  2. 2.
    Kutz FW, Barnes DG, Bottimore DP, Greim H, Bretthauer EW (1990) The International Toxicity Equivalency Factor (I-TEF) method of risk assessment of complex mixtures of dioxins and related compounds. Chemosphere 20:751–757CrossRefGoogle Scholar
  3. 3.
    van den Berg M, Birnbaum L, Bosveld ATC, Brunström B, Cook P, Feeley M, Giesy J, Hanberg A, Hasegawa R, Kennedy SW, Kubiak T, Larsen JC, van Leeuwen RFX, Liem AKD, Nolt C, Peterson RE, Poellinger L, Safe S, Schrenk D, Tillitt D, Tysklind M, Younes M, Waern F, Zacharewski T (1998) Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environ Health Perspect 106:775–792CrossRefGoogle Scholar
  4. 4.
    Ahlborg UG, Becking GC, Birnbaum LS, Brouwer A, Derks HJGM, Feeley M, Golor G, Hanberg A, Larsen JC, Liem AKD, Safe SH, Schlatter C, Wurn F, Younes M, Yrjanheikki E (1993) Toxic equivalency factors for dioxin-like PCBs: report of a WHO-ECEH and IPCS consultation, December 1993. Chemosphere 28:1049–1067CrossRefGoogle Scholar
  5. 5.
    Rose M, Poms R, Macarthur R, Pöpping B, Ulberth F (2011) What is the best way to ensure that valid analytical methods are used for food control? Qual Assur Saf Crops Foods 3(3):123–134CrossRefGoogle Scholar
  6. 6.
    Harries JM, Jones CM, Tatton JOG (1969) Pesticide residues in the total diet in England and Wales, 1966–1967: I—Organisation of a total diet study. J Sci Food Agric 20(4):242–245. doi: 10.1002/jsfa.2740200413 CrossRefGoogle Scholar
  7. 7.
    Buss DH, Lindsay DG (1978) Reorganization of the UK total diet study for monitoring minor constituents of food. Food Cosmet Toxicol 16(6):597–600. doi:http://dx.doi.org/10.1016/S0015-6264(78)80229-6
  8. 8.
    Peattie ME, Buss DH, Lindsay DG, Smart GA (1983) Reorganization of the British total diet study for monitoring food constituents from 1981. Food Chem Toxicol 21(4):503–507. doi:http://dx.doi.org/10.1016/0278-6915(83)90110-2
  9. 9.
    EFSA (European Food Safety Authority) (2010) Results of the monitoring of non dioxin-like PCBs in food and feed. EFSA J 8(7). doi: 10.2903/j.efsa.2010.1701
  10. 10.
    EFSA (European Food Safety Authority) (2012) Update of the monitoring of levels of dioxins and PCBs in food and feed. EFSA J 10(7). doi: 10.2903/j.efsa.2012.2832
  11. 11.
    Salmi T, Määttä A, Anttila P, Ruoho-Airola T, Amnell T (2002) Detecting trends of annual values of atmospheric pollutants by the Mann-Kendall test and Sen’s slope estimates – the Excel template application MAKESENS. Publications on Air Quality No. 31. Report code FMI-AQ-31. Finnish Meteorological Institute, Helsinki, FinlandGoogle Scholar
  12. 12.
    EFSA CONTAM Panel (EFSA Panel on Contaminants in the Food Chain) (2011) Scientific opinion on the risk to public health related to the presence of high levels of dioxins and dioxin-like PCBs in liver from sheep and deer. EFSA J 9(7). doi: 10.2903/j.efsa.2011.2297
  13. 13.
    Rose MD, Mortimer DN, Gem MG, Petch RG, Fernandes AR, Livesey CT (2010) Considerations for the regulation of polychlorinated dibenzodioxins, furans (PCDD/Fs) and biphenyls (PCBs) in liver. Qual Assur Saf Crops Foods 2(2):72–77CrossRefGoogle Scholar
  14. 14.
    Fernandes A, Mortimer D, Rose M, Gem M (2010) Dioxins (PCDD/Fs) and PCBs in offal: occurrence and dietary exposure. Chemosphere 81(4):536–540CrossRefGoogle Scholar
  15. 15.
    Van Overmeire I, Pussemier L, Waegeneers N, Hanot V, Windal I, Boxus L, Covaci A, Eppe G, Scippo ML, Sioen I, Bilau M, Gellynck X, De Steur H, Tangni EK, Goeyens L (2009) Assessment of the chemical contamination in home-produced eggs in Belgium: general overview of the CONTEGG study. Sci Total Environ 407(15):4403–4410. doi:http://dx.doi.org/10.1016/j.scitotenv.2008.10.066
  16. 16.
    Hites RA, Foran JA, Carpenter DO, Hamilton MC, Knuth BA, Schwager SJ (2004) Global assessment of organic contaminants in farmed salmon. Science 303(5655):226–229. doi: 10.1126/science.1091447 CrossRefGoogle Scholar
  17. 17.
    Foran JA, Carpenter DO, Hamilton MC, Knuth BA, Schwager SJ (2005) Risk-based consumption advice for farmed Atlantic and wild pacific salmon contaminated with dioxins and dioxin-like compounds. Environ Health Perspect 113(5):552–556. doi: 10.1289/ehp.7626 CrossRefGoogle Scholar
  18. 18.
    Rose M, Fernandes A, Schrenk D (2012) Emerging environmental organic contaminants in foods. Chem Contam Residues Food: 124–147Google Scholar
  19. 19.
    Falandysz J, Rose M, Fernandes AR (2012) Mixed poly-brominated/chlorinated biphenyls (PXBs): widespread food and environmental contaminants. Environ Int 44:118–127Google Scholar
  20. 20.
    Bergman Å, Rydén A, Law RJ, de Boer J, Covaci A, Alaee M, Birnbaum L, Petreas M, Rose M, Sakai S (2012) A novel abbreviation standard for organobromine, organochlorine and organophosphorus flame retardants and some characteristics of the chemicals. Environ Int 49:57–82CrossRefGoogle Scholar
  21. 21.
    Fernandes AR, Rose M, Mortimer D, Carr M, Panton S, Smith F (2011) Mixed brominated/chlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls: simultaneous congener-selective determination in food. J Chromatogr A 1218(51):9279–9287CrossRefGoogle Scholar
  22. 22.
    Falandysz J, Fernandes A, Gregoraszczuk E, Rose M (2014) The toxicological effects of halogenated naphthalenes: a review of aryl hydrocarbon receptor-mediated (dioxin-like) relative potency factors. J Environ Sci Health C 32(3):239–272CrossRefGoogle Scholar
  23. 23.
    Fernandes A, Mortimer D, Gem M, Smith F, Rose M, Panton S, Carr M (2010) Polychlorinated naphthalenes (PCNs): congener specific analysis, occurrence in food, and dietary exposure in the UK. Environ Sci Technol 44(9):3533–3538CrossRefGoogle Scholar
  24. 24.
    Fernandes A, Rose M (2013) Polychlorinated naphthalenes (PCNs) in foods: sources, analytical methodology, occurrence and human exposure. In: Fernandes A, Rose M (eds) Persistent organic pollutants and toxic metals in foods. pp 367–391. Woodhead Publishing Limited, Cambridge, UK. ISBN 978-0-85709-245-8.Google Scholar
  25. 25.
    Fernandes AR, Tlustos C, Rose M, Smith F, Carr M, Panton S (2011) Polychlorinated naphthalenes (PCNs) in Irish foods: occurrence and human dietary exposure. Chemosphere 85(3):322–328. doi: 10.1016/j.chemosphere.2011.06.093 CrossRefGoogle Scholar
  26. 26.
    Gizzi G, Hoogenboom LA, von Holst C, Rose M, Anklan E (2004) Determination of polychlorinated dibenzodioxins and polychlorinated dibenzofurans (PCDDs/PCDFs) in food and feed using a bioassay: result of a validation study. Organohalogen Compd 66:723–730Google Scholar
  27. 27.
    Hoogenboom R, Traag W, Fernandes A, Rose M (2015) European developments following incidents with dioxins and PCBs in the food and feed chain. Food Control 50:670–683CrossRefGoogle Scholar

Copyright information

© Crown Copyright 2016

Authors and Affiliations

  1. 1.FeraYorkUK

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