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Circulating P-Selectin and Its Glycoprotein Ligand in Nondiabetic Obstructive Sleep Apnea Patients

  • H. M. Winiarska
  • S. CoftaEmail author
  • L. Bielawska
  • A. Płóciniczak
  • T. Piorunek
  • E. Wysocka
Part of the Advances in Experimental Medicine and Biology book series


Selectins and their ligands play an important role in atherosclerosis. The role of these adhesion molecules in the pathogenesis of obstructive sleep apnea (OSA) may be of clinical relevance. Therefore, the aim of this study was to assess the serum content of platelet P-selectin (P-SEL) and P-selectin glycoprotein ligand 1 (PSGL-1) in different OSA stages. The study was performed in nondiabetic patients, aged 32–71, in whom OSA was verified by polysomnography. The apnea/hypopnea index (AHI) was used to stratify OSA stages: AHI <5, no sleep pathology (OSA-0); AHI 5–15, (OSA-1); AHI 16–30, (OSA-2); and AHI >30, (OSA-3). There were 16 patients in each group. P-SEL and PSGL-1 were assessed by ELISA kits. There were no appreciable differences in the patients’ glucose or high-specificity C-reactive protein content. We found that P-SEL and PSGL-1 significantly increased from OSA-0 to OSA-3. There were the following positive associations in all OSA patients: P-SEL vs. AHI, PSGL-1 vs. AHI, and P-SEL vs. PSGL-1. In addition, the adhesion molecules are associated with the anthropometric parameters, oxygen saturation, and sleep architecture in the OSA-1 group. We conclude that the adhesion molecules consistently increase in the blood of nondiabetic OSA patients, along with progression of disorder severity.


Adhesion molecules Apnea-hypopnea index Atherosclerosis Nondiabetic patients Obstructive sleep apnea Selectins Sleep pathology 


Conflict of Interest

The authors declare no conflicts of interests in relation to this article.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Bioethics Committee of Poznan University of Medical Sciences in Poland.

Informed Consent

Written informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • H. M. Winiarska
    • 1
  • S. Cofta
    • 1
    Email author
  • L. Bielawska
    • 2
  • A. Płóciniczak
    • 2
  • T. Piorunek
    • 1
  • E. Wysocka
    • 2
  1. 1.Department of Respiratory Medicine, Allergology and Pulmonary OncologyPoznan University of Medical SciencesPoznanPoland
  2. 2.Department of Laboratory DiagnosticsPoznan University of Medical SciencesPoznanPoland

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