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The Influence of National Guidelines on the Management of Community-Acquired Pneumonia in Children. Do Pediatricians Follow the Recommendations?

  • Grażyna Kraj
  • Joanna PeradzyńskaEmail author
  • Julita Chądzyńska
  • Marek Kulus
  • Krystian Wołoszyn
  • Teresa Jackowska
  • Maria Krajewska
  • Anna Mołdoch-Łukasik
  • Agnieszka Czubik-Przybyła
  • Aneta Górska-Kot
  • Katarzyna Krenke
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1211)

Abstract

This is a retrospective study whose main objective was to analyze the influence of the Polish Guidelines for the Management of Respiratory Tract Infections of 2010 (PGMRTI) on in-hospital treatment of children with community-acquired pneumonia (CAP). Files from four Warsaw hospitals were reviewed to identify children with uncomplicated CAP, treated before (2008–2009) (pre-PGMRTI) and after (2011–2012) (post-PGMRTI) publication of the guidelines. Predefined data on the management were compared. A cohort of 2,359 children (1,081 pre-PGMRTI and 1,278 post-PGMRTI) was included. We found that co-amoxiclav was the most common first-line therapy in children >3 months of age (34.6% and 40.4% pre- and post-PGMRTI, respectively), followed by cefuroxime (31.8% and 20.9% pre- and post-PGMRTI, respectively; p < 0.0001) and macrolides (17.4% and 24.5% pre- and post-PGMRTI, respectively; p < 0.0001). Amoxicillin was rarely used (5.4% and 4.9%, pre- and post-PGMRTI, respectively). The study revealed an overuse of inhaled bronchodilators, corticosteroids, and mucoactive drugs. Blood diagnostic tests were applied to a significant percentage of patients: blood cultures (41.2% and 44.5% pre-and post-PGMRTI, respectively) and serology for atypical pathogens (27.9% and 44.9% pre-and post-PGMRTI, respectively; p < 0.0001). The number of follow-up chest X-rays increased (30.5% and 53.8% pre- and post-PGMRTI, respectively; p < 0.0001). In conclusion, the study demonstrates an unsatisfactory influence of the guidelines on in-hospital management of CAP in children. Despite an explicit recommendation for the use of amoxicillin, it was still underused. Other methods of education and guideline dissemination are needed to optimize the prescribing of antibiotics.

Keywords

Antibiotics Children Community-acquired pneumonia Guidelines Management Recommendations 

Notes

Conflicts of Interest

The authors declare no conflicts of interest in relation to this article.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Bioethics Committee of Medical University of Warsaw, Poland. Since it is a retrospective study based on a review of patients’ files, the requirement of obtaining consent from individual study participants was waived.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Grażyna Kraj
    • 1
  • Joanna Peradzyńska
    • 2
    Email author
  • Julita Chądzyńska
    • 1
  • Marek Kulus
    • 1
  • Krystian Wołoszyn
    • 3
  • Teresa Jackowska
    • 3
    • 4
  • Maria Krajewska
    • 5
  • Anna Mołdoch-Łukasik
    • 5
  • Agnieszka Czubik-Przybyła
    • 6
  • Aneta Górska-Kot
    • 6
  • Katarzyna Krenke
    • 1
  1. 1.Department of Pediatric Pneumology and AllergyMedical University of WarsawWarsawPoland
  2. 2.Department of Epidemiology and BiostatisticsMedical University of WarsawWarsawPoland
  3. 3.Department of PediatricsBielanski HospitalWarsawPoland
  4. 4.Department of PediatricCenter of Postgraduate Medical EducationWarsawPoland
  5. 5.Department of Pediatrics and EndocrinologyMedical University of WarsawWarsawPoland
  6. 6.Department of PediatricsChildren’s HospitalWarsawPoland

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