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Skin Stem Cells, Their Niche and Tissue Engineering Approach for Skin Regeneration

  • Nur Kübra Çankirili
  • Ozlem Altundag
  • Betül Çelebi-SaltikEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1212)

Abstract

Skin is the main organ that covers the human body and acts as a protective barrier between the human body and the environment. Skin tissue as a stem cell source can be used for transplantation in therapeutic application in terms of its properties such as abundant, easy to access, high plasticity and high ability to regenerate. The immunological profile of these cells makes it a suitable resource for autologous and allogeneic applications. The lack of major histo-compatibility complex 1 is also advantageous in its use. Epidermal stem cells are the main stem cells in the skin and are suitable cells in tissue engineering studies for their important role in wound repair. In the last 30 years, many studies have been conducted to develop substitutions that mimic human skin. Stem cell-based skin substitutions have been developed to be used in clinical applications, to support the healing of acute and chronic wounds and as test systems for dermatological and pharmacological applications. In this chapter, tissue specific properties of epidermal stem cells, composition of their niche, regenerative approaches and repair of tissue degeneration have been examined.

Keywords

Epidermal stem cells Niche Skin Stem cells Tissue engineering 

Abbreviations

3D

Three dimensional

ATRA

All-Trans Retinoic Acid

BM

Basement Membrane

BM MSC

Bone Marrow Mesenchymal Stem Cell

BMP

Bone Morphogenic Protein

CD

Cluster of Differentiation

DNA

Deoxyribonucleic acid

DP

Dermal Papilla

ECM

Extracellular matrix

EB

Epidermolysis Bullosa

EGF

Epidermal Growth Factor

EPU

Epidermal Proliferative Unit

FDA

Food and Drug Administration

FGF

Fibroblast Growth Factor

GAG

Glycosaminoglycan

hASCs

Human Adipose Tissue Derived Stem/Stromal Cells

HF

Hair Follicle Bulge

IFE

Interfollicular Epidermis

IRS

Inner Root Sheath

Krt15+

Keratin15

MRNA

Messenger RNA

miRNAs

MicroRNAs

MMP

Matrix Metalloproteinase

Muse

Multilineage Differentiating Stress Enduring

ORS

Outer Root Sheath

Ptch

Patch

RER

Rough Endoplasmic Reticulum

RNA

Ribonucleic acid

Shh

Sonic Hedgehog

SSEA

Stage-Spesific Embryonic Antigen

TGF-β

Transforming Growth Factor-beta

UCPC

Umbilical cord pericyte cell

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Nur Kübra Çankirili
    • 1
    • 2
  • Ozlem Altundag
    • 1
    • 2
  • Betül Çelebi-Saltik
    • 1
    • 2
    Email author
  1. 1.Department of Stem Cell SciencesHacettepe University Graduate School of Health SciencesAnkaraTurkey
  2. 2.Center for Stem Cell Research and DevelopmentHacettepe UniversityAnkaraTurkey

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