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Necrotizing Enterocolitis and the Preterm Infant Microbiome

  • Jillian R. Baranowski
  • Erika C. ClaudEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series

Abstract

Bacterial colonization patterns in preterm infants differ from those of their term counterparts due to maternal microbial diversity, delivery mode, feeding methods, antibiotic use, and exposure to commensal microbiota and pathogens in the neonatal intensive care unit (NICU). Early gut microbiome dysbiosis predisposes neonates to necrotizing enterocolitis (NEC), a devastating intestinal disease with high morbidity and mortality. Though mechanisms of NEC pathogenesis are not fully understood, the microbiome is a promising therapy target for prevention and treatment. Direct administration of probiotics to preterm infants has been shown to reduce the incidence of NEC, but is not without risk. The immature immune systems of preterm infants leave them vulnerable to even beneficial bacteria. Further research is required to investigate both short-term and long-term effects of probiotic administration to preterm infants. Other methods of altering the preterm infant microbiome must also be considered, including breastfeeding, prebiotics, and targeting the maternal microbiome.

Keywords

Gastrointestinal microbiome Necrotizing enterocolitis Preterm birth Probiotics Very low birth weight infant 

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Authors and Affiliations

  1. 1.Pritzker School of MedicineUniversity of ChicagoChicagoUSA
  2. 2.Department of PediatricsThe University of Chicago Pritzker School of MedicineChicagoUSA

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