pp 1-10 | Cite as

Biological and Social Determinants of Maximum Oxygen Uptake in Adult Men

  • Stanisław B. NowakEmail author
  • Andrzej Jopkiewicz
  • Paweł Tomaszewski
Part of the Advances in Experimental Medicine and Biology book series


The maximum rate of O2 uptake (V̇O2max) is one of the most important positive indicators of health. While the V̇O2max decreases with age, reducing the capacity for physical effort, it can be considerably upregulated through optimal environmental interventions, including systematic physical activity. This study seeks to determine variations in the cardiorespiratory function, estimated from the level of V̇O2max, in 798 employed men aged 20–59, according to biological (age, physical activity, body mass index (BMI), and limb muscle strength and agility) and social (place of residence, education, occupation, economic status, and smoking) predictors. We found that the variables abovementioned, with the exception of smoking and hand strength, were significant predictors of V̇O2max in univariate logistic regression, with age (OR = 0.52; 95%CI 0.47–0.57) and BMI (OR = 0.91; 95%CI 0.90–0.93) having the greatest effect on V̇O2max. The additional predictors, established in multivariate analysis, were the place of residence, education, and hand and arm strength. The multivariate model was fairly well-fitted (Nagelkerke r2 = 0.54) and had a satisfactory prognostic value, with over 80% of cases classified correctly. Social variance in the V̇O2max makes it desirable to develop and implement the intervention programs with physical activity dedicated for men, especially men who are over the age of 50 years and have an excessive body mass, as this could reduce the risk of disorders and help improve the quality of life and workplace effectiveness of this group.


Cardiorespiratory function Health indicators Maximum oxygen uptake Physical activity Quality of life 


Conflicts of Interest

The authors declare no conflicts of interest in relation to this article.

Ethical Approval

All procedures performed in the study were in accordance with the ethical standards of the institutional national and/or research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Bioethics Committee of the Faculty of Medicine and Health Sciences of the Jan Kochanowski University in Kielce, Poland.

Informed Consent

Informed consent was obtained from all individual participants included in the study.


  1. Araújo CG, Herdy AH, Stein R (2013) Maximum oxygen consumption measurement: valuable biological marker in health and in sickness. Arq Bras Cardiol 100(4):e51–e53Google Scholar
  2. Araújo CGS, Castro CLB, Franca JF, Silva CGSE (2017) Aerobic exercise and the heart: discussing doses. Arq Bras Cardiol 108(3):271–275Google Scholar
  3. Arem H, Moore SC, Patel A, Hartge P, Berrington de Gonzalez A, Visvanathan K, Campbell PT, Freedman M, Weiderpass E, Adami HO, Linet MS, Lee IM, Matthews CE (2015) Leisure time physical activity and mortality: a detailed pooled analysis of the dose-response relationship. JAMA Intern Med 175(6):959–967Google Scholar
  4. Astrand PO, Ryhming I (1954) A nomogram for calculation of aerobic capacity (physical fitness) from pulse rate during sub–maximal work. J Appl Physiol 7:218–221Google Scholar
  5. Bauman AE, Reis RS, Sallis JF, Wells JC, Loos RJ, Martin BW (2012) Correlates of physical activity: why are some people physically active and others not? Lancet 380(9838):258–271Google Scholar
  6. Beall CM, Goldstein MC, Feldman ES (1985) The physical fitness of elderly Nepalese farmers residing in rugged mountain and flat terrain. J Gerontol 40(5):529–535Google Scholar
  7. Blair SN (2009) Physical inactivity: the biggest public health problem of the 21st century. Br J Sports Med 43(1):1–2Google Scholar
  8. Després JP (2016) Physical activity, sedentary behaviors, and cardiovascular health: when will cardiorespiratory fitness become a vital sign? Can J Cardiol 32(4):505–513Google Scholar
  9. Ding D, Lawson KD, Kolbe–Alexander TL, Finkelstein EA, Katzmarzyk PT, van Mechelen W, Pratt M, Lancet Physical Activity Series 2 Executive Committee (2016) The economic burden of physical inactivity: a global analysis of major non–communicable diseases. Lancet 388(10051):1311–1324Google Scholar
  10. Dumith SC, Hallal PC, Reis RS, Kohl HW 3rd (2011) Worldwide prevalence of physical inactivity and its association with human development index in 76 countries. Prev Med 53(1–2):4–28Google Scholar
  11. Evans J, Frank B, Oliffe JL, Gregory D (2011) Health, illness, men and masculinities (HIMM): a theoretical framework for understanding men and their health. J Mens Health 8(1):15Google Scholar
  12. Fleg JL, Morrell CH, Bos AG, Brant LJ, Talbot LA, Wright JG, Lakatta EG (2005) Accelerated longitudinal decline of aerobic capacity in healthy older adults. Circulation 112(5):674–682Google Scholar
  13. Gebel K, Ding D, Chey T, Stamatakis E, Brown WJ, Bauman AE (2015) Effect of moderate to vigorous physical activity on all–cause mortality in middle–aged and older Australians. JAMA Intern Med 175(6):970–977Google Scholar
  14. Giorgianni SJ Jr, Porche ST, Williams ST, Matope JH, Leonard BL (2013) Developing the discipline and practice of comprehensive men’s health. Am J Mens Health 7(4):342–349Google Scholar
  15. Gurven M, Jaeggi AV, Kaplan H Cummings D (2013) Physical activity and modernization among Bolivian Amerindians. PLoS One 8:1–13Google Scholar
  16. Hagströmer M, Kwak L, Oja P, Sjöström M (2015) A 6 year longitudinal study of accelerometer–measured physical activity and sedentary time in Swedish adults. J Sci Med Sport 18(5):553–557Google Scholar
  17. Hallal PC, Andersen LB, Bull FC, Guthold R, Haskell W, Ekelund U (2012) Global physical activity levels: surveillance progress, pitfalls, and prospects. Lancet 380(9838):247–257Google Scholar
  18. Hawkins MN, Raven PB, Snell PG, Stray–Gundersen J, Levine BD (2007) Maximal oxygen uptake as a parametric measure of cardiorespiratory capacity. Med Sci Sports Exerc 39(1):103–107Google Scholar
  19. Huang G, Wang R, Chen P, Huang SC, Donnelly JE, Mehlferber JP (2016) Dose–response relationship of cardiorespiratory fitness adaptation to controlled endurance training in sedentary older adults. Eur J Prev Cardiol 23(5):518–529Google Scholar
  20. Hupin D, Roche F, Gremeaux V, Chatard JC, Oriol M, Gaspoz JM, Barthélémy JC, Edouard P (2015) Even a low–dose of moderate–to–vigorous physical activity reduces mortality by 22% in adults aged ≥60 years: a systematic review and meta–analysis. Br J Sports Med 49(19):1262–1267Google Scholar
  21. Jackson AS, Sui X, Hébert JR, Church TS, Blair SN (2009) Role of lifestyle and aging on the longitudinal change in cardiorespiratory fitness. Arch Intern Med 169(19):1781–1787Google Scholar
  22. Katzmarzyk PT, Mason C (2009) The physical activity transition. J Phys Act Health 6:269–280Google Scholar
  23. Kenney WL, Wilmore JH, Costill D (2015) Physiology of Sport and Exercise. 6th Edition with Web Study Guide. Publisher: Human Kinetics Publishers; ISBN-13: 9781450477673Google Scholar
  24. Kwan MY, Cairney J, Faulkner GE, Pullenayegum EE (2012) Physical activity and other health–risk behaviors during the transition into early adulthood: a longitudinal cohort study. Am J Prev Med 42(1):14–20Google Scholar
  25. Lakoski SG, Barlow CE, Farrell SW, Berry JD, Morrow JR Jr, Haskell WL (2011) Impact of body mass index, physical activity, and other clinical factors on cardiorespiratory fitness (from the Cooper Center longitudinal study). Am J Cardiol 108(1):34–39Google Scholar
  26. Laukkanen JA, Zaccardi F, Khan H, Kurl S, Jae SY, Rauramaa R (2016) Long–term change in cardiorespiratory fitness and all–cause mortality: a population–based follow–up study. Mayo Clin Proc 91(9):1183–1188Google Scholar
  27. Lee D, Artero EG, Sui X, Blair SN (2010) Mortality trends in the general population: the importance of cardiorespiratory fitness. J Psychopharmacol 24(4):27–35Google Scholar
  28. Lee D, Sui X, Artero EG, Lee IM, Church TS, McAuley PA, Stanford FC, Kohl HW 3rd, Blair SN (2011) Long–term effects of changes in cardiorespiratory fitness and body mass index on all–cause and cardiovascular disease mortality in men: the Aerobics Center Longitudinal Study. Circulation 124(23):2483–2490Google Scholar
  29. Leone JE, Rovito MJ (2013) Normative content and health inequity enculturation: a logic model of men’s health advocacy. Am J Mens Health 7:243–254Google Scholar
  30. Malina RM, Litle BB (2008) Physical activity: the present in the context of the past. Am J Hum Biol 20(4):373–391Google Scholar
  31. Mattson MP (2012) Evolutionary aspects of human exercise–born to run purposefully. Ageing Res Rev 11(3):347–352Google Scholar
  32. Muthuri SK, Wachira LM, LeBlanc AG, Francis CE, Sampson M, Onywera VO, Tremblay MS (2014) Temporal trends and correlates of physical activity, sedentary behaviour, and physical fitness among school–aged children in sub–Saharan Africa: a systematic review. Int J Environ Res Public Health 11:3327–3359Google Scholar
  33. Nussey D, Coulson T, Festa–Bianchet M, Gaillard JM (2008) Measuring senescence in wild animal populations: towards a longitudinal approach. Funct Ecol 22:393–406Google Scholar
  34. O’Keefe JH, Vogel R, Lavie CJ, Cordain I (2010) Organic fitness: physical activity consistent with our hunter–gatherer heritage. Phys Sportsmed 38(4):11–18Google Scholar
  35. Pimentel AE, Gentile CL, Tananka H, Seals DR, Gates PE (2003) Greater rate of decline in maximal aerobic capacity with age in endurance–trained than in sedentary men. J Appl Physiol 94(6):2406–2413Google Scholar
  36. Pisor AC, Gurven M, Blackwell AD, Kaplan H, Yetish G (2013) Patterns of senescence in human cardiovascular fitness: VO2 max in subsistence and industrialized populations. Am J Hum Biol 25(6):756–769Google Scholar
  37. Powell KE, Paluch AE, Blair SN (2011) Physical activity for health: what kind? How much? How intense? On top of what? Annu Rev Public Health 32:349–365Google Scholar
  38. Raichlen DA, Foster AD, Gerdeman GL, Seillier A, Giuffrida A (2012) Wired to run: exercise–induced endocannabinoid signaling in humans and cursorial mammals with implications for the ‘runner’s high’. J Exp Biol 215:1331–1336Google Scholar
  39. Rowe GC, Safdar A, Arany Z (2014) Running forward: new frontiers in endurance exercise biology. Circulation 129(7):798–810Google Scholar
  40. Sagiv M, Goldhammer E, Ben–Sira D, Amir R (2007) What maintains energy supply at peak aerobic exercise in trained and untrained older men? Gerontology 53(6):357–361Google Scholar
  41. Smith M, Hosking J, Woodward A, Witten K, MacMillan A, Field A, Baas P, Mackie H (2017) Systematic literature review of built environment effects on physical activity and active transport – an update and new findings on health equity. Int J Behav Nutr Phys Act 14(1):158Google Scholar
  42. US Department of Health and Human Services (2008) Physical activity guidelines for americans. ODPHP Publ. No. U0036. Accessed on 19 Oct 2018
  43. WHO (2008) Waist circumference and waist–hip ratio. Report of a WHO Expert Consultation. Geneva, SwitzerlandGoogle Scholar
  44. WHO (2009) Global health risks: mortality and burden of disease attributable to selected major risks. WHO, GenevaGoogle Scholar
  45. Zhang K, Werner P, Sun M, Pi–Sunyer FX, Boozer CN (2003) Measurement of human daily physical activity. Obes Res 11:33–40Google Scholar

Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Stanisław B. Nowak
    • 1
    Email author
  • Andrzej Jopkiewicz
    • 2
  • Paweł Tomaszewski
    • 3
  1. 1.Department of Physical EducationKazimierz Pulaski University of Technology and Humanities in RadomRadomPoland
  2. 2.Department of AuxologyJan Kochanowski University in KielceKielcePoland
  3. 3.Department of BiometryJozef Pilsudski University of Physical Education in WarsawWarsawPoland

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