Mesenchymal Stem Cells and Calcium Phosphate Bioceramics: Implications in Periodontal Bone Regeneration

  • Carola Millan
  • Juan F. Vivanco
  • Isabel M. Benjumeda-Wijnhoven
  • Suncica Bjelica
  • Juan F. SantibanezEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1107)


In orthopedic medicine, a feasible reconstruction of bone structures remains one of the main challenges both for healthcare and for improvement of patients’ quality of life. There is a growing interest in mesenchymal stem cells (MSCs) medical application, due to their multilineage differentiation potential, and tissue engineering integration to improve bone repair and regeneration. In this review we will describe the main characteristics of MSCs, such as osteogenesis, immunomodulation and antibacterial properties, key parameters to consider during bone repair strategies. Moreover, we describe the properties of calcium phosphate (CaP) bioceramics, which demonstrate to be useful tools in combination with MSCs, due to their biocompatibility, osseointegration and osteoconduction for bone repair and regeneration. Also, we overview the main characteristics of dental cavity MSCs, which are promising candidates, in combination with CaP bioceramics, for bone regeneration and tissue engineering. The understanding of MSCs biology and their interaction with CaP bioceramics and other biomaterials is critical for orthopedic surgical bone replacement, reconstruction and regeneration, which is an integrative and dynamic medical, scientific and bioengineering field of research and biotechnology.


Bioceramics Bone regeneration Calcium phosphate Dental Mesenchymal stem cells Tissue engineering 



Alkaline phosphatase


Bone marrow


Bone morphogenetic proteins


calcium phosphate


Cluster of differentiation


Dental follicle progenitor cells


Dental pulp


Gingival mesenchymal stem cells




Human umbilical vein endothelial cells


Indoleamine 2, 3-dioxygenase






Mesenchymal stem cells


programmed death


Platelet-derived growth factor


Periodontal ligament


Prostaglandin E2


Poly-ɛ-caprolacton coated-biphasic calcium phosphate


Runt-related transcription factor 2


Apical papilla derived stem cells


Stromal cell-derived factor 1


Exfoliated deciduous teeth


Transforming growth factor-β1


T helper


Tumor necrosis factor-α


T Regulatory


beta-tricalcium phosphate



The authors are grateful to Dr. Marija Bozic for her excellent and valuable editorial assistance. We apologize to those colleagues whose work, although relevant to the issues dealt within this review, has not been included due to space limitations. This work was supported by Fondo Nacional de Ciencia y Tecnologia (FONDECYT No 11170957) and Ministry of education, Science and Technological Development of the Republic of Serbia (grants 175024 and 175053). We also thank to the support of visiting professor program of UBO to J.F.S.

Conflict of Interest

The authors declare no potential conflict of interest.

Ethical Approval

The authors declare that this article does not contain any studies with human participants or animals.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Carola Millan
    • 1
    • 2
  • Juan F. Vivanco
    • 2
  • Isabel M. Benjumeda-Wijnhoven
    • 2
  • Suncica Bjelica
    • 3
  • Juan F. Santibanez
    • 3
    • 4
    Email author
  1. 1.Facultad de Artes Liberales, Facultad de Ingeniería y CienciasUniversidad Adolfo IbáñezViña del MarChile
  2. 2.Facultad de Ingeniería y CienciasUniversidad Adolfo IbáñezViña del MarChile
  3. 3.Group for Molecular oncology group, Institute for Medical ResearchUniversity of BelgradeBelgradeRepublic of Serbia
  4. 4.Centro Integrativo de Biología y Química Aplicada (CIBQA)Universidad Bernardo O’HigginsSantiagoChile

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