Effects of Low-Level Laser Therapy in Autism Spectrum Disorder
The study examined the efficacy of low-level laser therapy, a form of photobiomodulation, for the treatment of irritability associated with autistic spectrum disorder in children and adolescents aged 5–17 years. Twenty-one of the 40 participants received eight 5-min procedures administered to the base of the skull and temporal areas across a 4-week period (test, i.e., active treatment participants). All the participants were evaluated with the Aberrant Behavior Checklist (ABC), with the global scale and five subscales (irritability/agitation, lethargy/social withdrawal, stereotypic behavior, hyperactivity/noncompliance, and inappropriate speech), and the Clinical Global Impressions (CGI) Scale including a severity-of-illness scale (CGI-S) and a global improvement/change scale (CGI-C). The evaluation took place at baseline, week 2 (interim), week 4 (endpoint), and week 8 (post-procedure) of the study. The adjusted mean difference in the baseline to study endpoint change in the ABC irritability subscale score between test and placebo participants was −15.17 in favor of the test procedure group. ANCOVA analysis found this difference to be statistically significant (F = 99.34, p < 0.0001) compared to the baseline ABC irritability subscale score. The study found that low-level laser therapy could be an effective tool for reducing irritability and other symptoms and behaviors associated with the autistic spectrum disorder in children and adolescents, with positive changes maintained and augmented over time.
KeywordsAutism spectrum disorder Brain Clinical trial Low-level laser therapy Neuronal networks Photobiomodulation
The project was funded by Erchonia Corp., Melbourne, FL, the producers of the equipment employed in this study. The authors would like to thank Ms. Elvira Walls for her assistance with the statistical analysis and research methodology.
Conflicts of Interest
None of the authors have any fiduciary interests in the research reported herein or with the source of funding.
- Constantino JN, Davis SA, Todd RD, Schindler MK, Gross MM, Brophy SL, Metzger LM, Shoushtari CS, Splinter R, Reich W (2003) Validation of a brief quantitative measure of autistic traits: comparison of the social responsiveness scale with the autism diagnostic interview-revised. J Autism Dev Disord 33(4):427–433CrossRefGoogle Scholar
- deFreitas LF, Hamblin MR (2016) Proposed mechanisms of photobiomodulation or low–level light therapy. IEEE J Select Topics Quant Electronics 22:7000417Google Scholar
- Farmer C, Aman MG (2012) Aberrant behavior checklist. In: Volkmar F (ed) Encyclopedia of autism Spectrum disorders. Springer, New YorkGoogle Scholar
- Machado C, Estévez M, Leisman G, Melillo R, Rodríguez R, DeFina P, Hernández A, Pérez–Nellar J, Naranjo R, Chinchilla M, Garófalo N, Vargas J, Beltrán C (2015) qEEG spectral and coherence assessment of autistic children in three different experimental conditions. J Autism Dev Disord 45:406–424CrossRefGoogle Scholar
- Naeser MA, Zafonte R, Krengel MH, Martin PI, Frazier J, Hamblin MR, Knight JA, Meehan WP 3rd, Baker EH (2014) Significant improvements in cognitive performance post–transcranial, red/near–infrared light–emitting diode treatments in chronic, mild traumatic brain injury: open–protocol study. J Neurotrauma 31:1008–1017CrossRefGoogle Scholar
- Schiffer F, Johnston AL, Ravichandran C, Polcari A, Teicher MH, Webb RH, Hamblin MR (2009) Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety. Behav Brain Funct 5:46CrossRefGoogle Scholar
- Wang L, Hu L, Grygorczyk R, Shen X, Schwarz W (2015) Modulation of extracellular ATP content of mast cells and DRG neurons by irradiation: studies on underlying mechanism of low–level–laser therapy. Med Inf 2015:630361Google Scholar
- Zivin JA, Albers GW, Bornstein N, Chippendale T, Dahlof B, Devlin T, Fisher M, Hacke W, Holt W, Ilic S, Kasner S, Lew R, Nash M, Perez J, Rymer M, Schellinger P, Schneider D, Schwab S, Veltkamp R, Walker M, Streeter J, NeuroThera Effectiveness and Safety Trial-2 Investigators (2009) Effectiveness and safety of transcranial laser therapy for acute ischemic stroke. Stroke 40:1359–1364CrossRefGoogle Scholar