Bioengineered Scaffolds for Stem Cell Applications in Tissue Engineering and Regenerative Medicine

  • Maryam Rahmati
  • Cristian Pablo Pennisi
  • Ali MobasheriEmail author
  • Masoud MozafariEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1107)


Stem cell-based therapies, harnessing the ability of stem cells to regenerate damaged or diseased tissues, are under wide-ranging consideration for regenerative medicine applications. However, limitations concerning poor cell persistence and engraftment upon cell transplantation still remain. During the recent years, several types of biomaterials have been investigated to control the fate of the transplanted stem cells, aiming to increase their therapeutic efficiency. In the present chapter we focus on the general properties of some of these biomaterials, which include polymers, ceramics, and nano-biomaterials. In the first part of the chapter, a brief explanation about stem cell biology, sources, and their microenvironment is provided. The second part of the chapter presents some of the most recent studies investigating different types of biomaterials and approaches that aim to mimic the stem cell microenvironment for a more precise control of the stem cell fate.


Biomaterials Regenerative medicine Tissue engineering Stem cells Microenvironment 





Embryonic stem cells


Induced pluripotent stem cells


Hematopoietic stem cells


Sub-granular zone


Extracellular matrix


Bone marrow mesenchymal stem cells


Amniotic fluid derived stem cells


Adipose-derived stem cells


Hyaluronic acid






Poly (ethylene glycol)


poly (vinyl alcohol)


poly (lactic acid)


poly (lactic-co-glycolic acid)




Bioactive glass


Carbon nanotubes


Diamond-like carbon


Carbon nanofibers


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Cellular and Molecular Research CenterIran University of Medical Sciences (IUMS)TehranIran
  2. 2.Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in MedicineIran University of Medical Sciences (IUMS)TehranIran
  3. 3.Bioengineering Research Group, Nanotechnology and Advanced Materials DepartmentMaterials and Energy Research Center (MERC)TehranIran
  4. 4.Laboratory for Stem Cell Research, Department of Health Science and TechnologyAalborg UniversityAalborgDenmark
  5. 5.The D-BOARD FP7 ConsortiumSurreyUK
  6. 6.The APPROACH IMI ConsortiumSurreyUK
  7. 7.Faculty of Health and Medical SciencesUniversity of SurreySurreyUK
  8. 8.Arthritis Research UK Centre for Sport, Exercise and Osteoarthritis, Queen’s Medical CentreNottinghamUK
  9. 9.Department of Regenerative MedicineState Research Institute Centre for Innovative MedicineVilniusLithuania

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