Abstract
Transplantation is considered as one of the methods for the treatment of autoimmune diseases. There are different sorts of transplantation which improved the situation for the cure of different kinds of autoimmune diseases. Cord blood transplantation is favored over other transplant techniques. The propelled treatments incorporate interferon administrative elements and mesenchymal stromal cells for the management of immune system issue particularly in the treatment of rheumatoid joint inflammation. According to the studies conducted, it was proven that cord blood/UC mesenchymal cells along with DMARDs, without consistent organization expanded the level of administrative regulatory T-cells of the peripheral blood which might be a protected and huge technique for the treatment of patients experiencing rheumatoid joint inflammation. This review article focusses on different organ transplantation and alternative methods to treat autoimmune condition like rheumatoid arthritis. Using 3D printing and artificial intelligence are some of the recent trends that may be used for the management of autoimmune diseases.
Keywords
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- DMARDs:
-
Disease-Modifying Antirheumatic Drugs
- UC:
-
Umbilical Cord
- MSCs:
-
Mesenchymal Stromal Cells
- RA:
-
Rheumatoid Arthritis
- SCs:
-
Stem Cells
- HSCs:
-
Hematopoietic Stem Cells
- GVHD:
-
Graft Versus Host Disease
- RBCs:
-
Red Blood Cells
- IRFs:
-
Interferon Regulatory Factors
- HLA:
-
Human Leukocyte Antigen
- FLSs:
-
Fibroblast-like synoviocytes
- TH1:
-
T helper 1
- IL-18BP:
-
Inter-leukin18 Binding Protein
- TNFα-:
-
Tumor Necrosis Factor alpha
- NFKB:
-
Nuclear Factor kappa-light-chain-enhancer of activated B cells
- cJUN:
-
c-Jun N-terminal kinase
- ACPAs:
-
Anticitrullinated protein antibodies
- EULAR:
-
European Group Against Ailment
- DAS:
-
Disease Activity Scores
- UC-MSC:
-
Umbilical Cord-derived MSC
- NOTA:
-
National Organ Transplant Act
- OPTN:
-
Organ Procurement and Transplantation Network
- PSDA:
-
Patient Self-Determination Act
- SGB V:
-
Sozialgesetzbuch Fünftes Buch
- TPG:
-
German Transplantation Law
- ZTCC:
-
Zonal Transplant Coordination Center
- ANNs:
-
Artificial Neural Network
- ESCs:
-
Embryonic Stem Cells
- siRNA:
-
small interfering Ribonucleic Acid
- NOC:
-
No Objection Certificate
- NGO:
-
Non-Governmental Organization
- 3D:
-
3 Dimensional
References
Alexander BR P OFM (2008) Organ transplantation (Catholic-Ethical-Appraisal)
Arthur C (2008) Regulation of organ transplants: a comparison between the systems in the United States and Singapore
Aryani A, Denecke B (2016) Exosomes as a nanodelivery system: a key to the future of neuromedicine. Mol Neurobiol 53:818–834
Ballen KK (2005) New trends in umbilical cord blood transplantation. Blood 105:3786–3792
Barnard CN (1967) A human cardiac transplant: an interim report of a successful operation performed at Groote Schuur hospital, Cape Town. S Afr Med J 41(48):1271–1274
Barnard CN, Wolpowitz A, Losman JG (1977) Heterotopic cardiac transplantation with a xenograft for assistance of the left heart in cardiogenic shock after cardiopulmonary bypass. S Afr Med J 52(26):1035–1038
Bartholomew A, Sturgeon C, Siatskas M, Ferrer K, McIntosh K, Patil S, Hardy W, Devine S, Ucker D, Deans R, Moseley A, Hoffman R (2002) Mesenchymal stem cells suppress lym-phocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol 30:42–48
Battistini A (2009) Interferon regulatory factors in hematopoietic cell differentiation and immune regulation. J Interf Cytokine Res 29(12):765–780
Böhm M, Luger TA, Schneider M, Schwarz T, Kuhn A (2006) New insight into immunosuppression and treatment of autoimmune diseases. Clin Exp Rheumatol 24(1 Suppl 40):S67–S71
Briceño J, Cruz-Ramírez M, Prieto M, Navasa M, Ortiz de Urbina J, Orti R, Gómez-Bravo MÁ, Otero A, Varo E, Tomé S, Clemente G, Bañares R, Bárcena R, Cuervas-Mons V, Solórzano G, Vinaixa C, Rubín A, Colmenero J, Valdivieso A, Ciria R, Hervás-Martínez C, de la Mata M (2014) Use of artificial intelligence as an innovative donor-recipient matching model for liver transplantation: results from a multicenter Spanish study. J Hepatol 61(5):1020–1028
Chandrashekara S (2012) The treatment strategies of autoimmune disease may need a different approach from conventional. Indian J Pharm 44(6):665–671
Cooper DKC (2012) A brief history of cross-species organ. Transplantation 25(1):49–57
Djouad F, Fritz V, Apparailly F, Louis-Plence P, Bony C, Sany J, Jorgensen C, Noël D (2005) Reversal of the immunosuppressive properties of mesenchymal stem cells by tumor necrosis factor alpha in collagen-induced arthritis. Arthritis Rheum 52(5):1595–1603
Feldmann M, Steinman L (2005) Design of effective immunotherapy for human autoimmunity. Nature 435:612–619
Ganesan R, Rasool M (2017) Fibroblast-like synoviocytes-dependent effector molecules as a critical mediator for rheumatoid arthritis: current status and future directions. Int Rev Immunol 36(1):20–30
Giles GR, Boehmig HJ, Amemiya H, Halgrimson CG, Starzl TE (1970) Clinical heterotransplantation of the liver. Transplant Proc 2(4):506–512
Gracie JA, Forsey RJ, Chan WL, Gilmour A, Leung BP, Greer MR, Kennedy K, Carter R, Wei XQ, Xu D, Field M, Foulis A, Liew FY, McInnes IB (1999) A proinflammatory role for IL-18 in rheumatoid arthritis. J Clin Invest 104(10):1393–1401
Groth CG, Korsgren O, Tibell A, Tollemar J, Moller E, Bolinder J, Ostman J, Reinholt FP, Hellerstrom C, Andersson A (1994) Transplantation of porcine fetal pancreas to diabetic patients. Lancet 344(8934):1402–1404
Hara H, Cooper DKC (2010) The immunology of corneal xenotransplantation:a review of the literature. Xenotransplantation 17(5):338–349
Hara H, Cooper DKC (2011) Xenotransplantation–the future of corneal transplantation? Cornea 30(4):371–378
Hochedlinge K, Jaenisch R (2003) Nuclear transplantation, embryonic stem cells, and the potential for cell therapy. N Engl J Med 349:275–286
Hunter W (1743) Of the structure and disease of articulating cartilages. Clin Orthop Relat Res 1995:3–6
Hunter W (1744) Of the structure and diseases of articular cartilages. Phil Trans 1744:514–521
Hurgin V, Novick D, Rubinstein M (2002) The promoter of IL-18 binding protein: activation by an IFN-gamma -induced complex of IFN regulatory factor 1 and CCAAT/enhancer binding protein beta. Proc Natl Acad Sci USA 99(26):16957–16962
Judet H (1908) Essai sur La greffe des tissus articularies. C R Acad Sci 193–196:600–603
Koc ON, Gerson SL, Cooper BW, Dyhouse SM, Haynesworth SE, Caplan AI, Lazarus HM (2000) Rapid hematopoietic recovery after co-infusion of autologous-blood stem cells and culture- expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy. J Clin Oncol 18:307–316
Langer F, Gross AE (1974) Immunogenicity of allograft articular cartilage. J Bone Joint Surg Am 56:297–304
Lexer E (1925) Joint transplantation and arthroplasty. Surg Cynecol 40:782–789
Liang J, Li X, Zhang H, Wang D, Feng X, Wang H, Hua B, Liu B, Sun L (2012) Allogeneic mesenchymal stem cells transplantation in patients with refractory RA. Clin Rheumatol 31:157–161
Lubin BH, Shearer WT (2007) Cord blood banking for potential future transplantation. Pediatrics 119:165–170
Marotte H, Tsou PS, Rabquer BJ, Pinney AJ, Fedorova T, Lalwani N, Koch AE (2011) Blocking of interferon regulatory factor 1 reduces tumor necrosis factor alpha-induced interleukin-18 bioactivity in rheumatoid arthritis synovial fibroblasts by induction of interleukin-18 binding protein a: role of the nuclear interferon regulatory factor 1-NF-kappaB-c-jun complex. Arthritis Rheum 63(11):3253–3262
Matta B, Uthoff-Hachenberg C, Waisman A (2017) Interferon regulatory factor signaling in autoimmune disease. Cytokine 98:15–26
Meyer EA, Hanna K, Gebbie K (2005) Cord blood: establishing a national hematopoietic stem cell bank program. The National Academies Press, Washington, DC
Nanda A, Filis A, Kalakoti P (2016) Mythological and pre-historical origins of neurosurgery. World Neurosurg 89:568–573
Nehyba J, Hrdlickova R, Bose HR (2009) Dynamic evolution of immune system regulators: the history of the interferon regulatory factor family. Mol Biol Evol 26(11):2539–2550
Nikalaou VS, Giannoudis PV (2017) History of osteochondral allograft transplantation injury. Int J Care Injured 48(7):1283–1286
Ning S (2014) Interferon regulatory factors and autoimmune diseases, HSOA. J Med Genom Biomarkers 1:001
Salloum WD, Pan HF, Xu Y, Ye DQ (2013) Interferon regulatory factor 5 and autoimmune lupus. Expert Rev Mol Med 15:e6
Ra JC, Kang SK, Shin IS, Park HG, Joo SA, Kim JG, Kang BC, Lee YS, Nakama K, Piao M, Sohl B, Kurtz A (2011) Stem cell treatment for patients with autoimmune dis- ease by systemic infusion of culture- expanded autologous adipose tissue derived mesenchymal stem cells. J Transl Med 9:181
Reemtsma K, Mccracken BH, Schlegel JU, Pearl MA, Pearce CW, Dewitt CW, Smith PE, Hewitt RL, Flinner RL, Creech O Jr (1964) Renal heterotransplantation in man. Ann Surg 160:384–410
Slabbert M, Mnyongani FD (2011) Law, religion and organ transplants. Koers 76(2):261–282
Sousa C, Pereira I, Santos AC, Carbone C, Kovačević AB, Silva AM, Souto EB (2017) Targeting dendritic cells for the treatment of autoimmune diseases. Colloids Surf B Biointerfaces 158:237–248
Starzl TE (1969) Orthotopic heterotransplantation. In: Starzl TE (ed) Experience in hepatic transplantation. WB Saunders, Philadelphia, p 408
Starzl TE, Marchioro TL, Faris TD, McCardle RJ, Iwaski Y (1966) Avenues of future research in homotransplantation of the liver with particular reference to hepatic supportive procedures, antilymphocyte serum, and tissue typing. Am J Surg 112(3):391–400
Starzl TE, Ishikawa M, Putnam CW, Porter KA, Picache R, Husberg BS, Halgrimson CG, Schroter G (1974) Progress in and deterrents to orthotopic liver transplantation, with special reference to survival, resistance to hyperacute rejection, and biliary duct reconstruction. Transplant Proc 6(4 Suppl1):129–139
Starzl TE, Fung J, Tzakis A, Todo S, Demetris AJ, Marino IR, Doyle H, Zeevi A, Warty V, Michaels M, Kusne S, Rudert WA, Trucco M (1993) Baboon-to-human liver transplantation. Lancet 341(8837):65–71
Tamura T, Yanai H, Savitsky D, Taniguchi T (2008) The IRF family transcription factors in immunity and oncogenesis. Annu Rev Immunol 26:535–584
Tyndall A, Uccelli A (2009) Multipotent mesenchymal stromal cells for autoimmune diseases: teaching new dogs old tricks. Bone Marrow Transplant 43:821–828
Van der Kooij SM, de Vries- Bouwstra JK, Goekoop- Ruiterman YP, van Zeben D, Kerstens PJ, Gerards AH, de Vries-Bouwstra JK, Güler-Yüksel M, Zwinderman AH, Kerstens PJSM, van der Lubbe PAHM, de Beus WM, Grillet BAM, Ronday HK, Huizinga TWJ, Breedveld FC, Dijkmans BAC, Allaart CF (2007) Limited efficacy of conventional DMARDs after initial methotrexate failure in patients with recent onset rheumatoid arthritis treated according to the disease activity score. Ann Rheum Dis 66:1356–1362
Wang L, Cong X, Liu G, Zhou J, Bai B, Li Y, Bai W, Li M, Ji H, Zhu D, Wu M, Liu Y (2013) Human umbilical cord mesenchymal stem cell therapy for patients with active rheumatoid arthritis: safety and efficacy. Stem Cells Develop 22(24):3192–3202
Zhu W, Li X, Fang S, Zhang X, Wang Y, Zhang T, Li Z, Xu Y, Qu S, Liu C, Gao F, Pan H, Wang G, Li H, Sun B (2015) Anti-citrullinated protein antibodies induce macrophage subset disequilibrium in RA patients. Inflammation 38(6):2067–2075
Zhu W, Qu X, Zhu J, Ma X, Patel S, Liu J, Chen S (2017) Direct 3D bioprinting of prevascularized tissue constructs with complex microarchitecture. Biomaterials 124:106–115
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Shende, P., Rodrigues, B., Gaud, R.S. (2018). Transplantation and Alternatives to Treat Autoimmune Diseases. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 2. Advances in Experimental Medicine and Biology(), vol 1089. Springer, Cham. https://doi.org/10.1007/5584_2018_177
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DOI: https://doi.org/10.1007/5584_2018_177
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