Long-Term Exposure to Ambient Air Pollution in Childhood-Adolescence and Lung Function in Adulthood

  • A. Dubrowski
  • K. Kliś
  • M. Żurawiecka
  • K. Dereń
  • M. Barszcz
  • D. Nowakowski
  • I. WronkaEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1113)


The aim of the study was to evaluate the effect of air pollution in the dwelling place during childhood-adolescence on respiratory function in early adulthood. The study was conducted in 220 female and 160 male university undergraduates in the cities of Cracow and Wroclaw in Poland and consisted of spirometry to assess lung function. The subjects’ exposure to pollution during childhood-adolescence was assessed from the data acquired by the Polish Chief Inspectorate for Environmental Protection. We found differences in all spirometry variables depending on benz[a]piren exposure, in FVC% and FEV1/%FVC depending on PM2.5 content, and in FVC% depending on NO2 content. Statistically significant differences in spirometry variables were also found in relation to the degree of urbanization of the place of living during the early life period in question. The higher the urbanization, the higher is FEV1% and FCV%, and the lower FEV1/%FVC. Additionally, undergraduates of Cracow University had worse lung function compared to those of Wroclaw University. In conclusion, air pollution in the dwelling place during childhood-adolescence has an impact on lung function in early adulthood, independently of the current exposure to pollutants.


Adolescence Adulthood Air pollution Lung function Particular matters Spirometry Urbanization 



The study was supported by a grant from the Faculty of Biology and Earth Science, Jagiellonian University in Cracow no. DS/MND/WBiNoZ/17/2017.

Conflicts of Interest

The authors declare no conflicts of interest in relation to this article.


  1. Ackermann-Liebrich U, Leuenberger P, Schwartz J et al (1997) Lung function and long term exposure to air pollutants in Switzerland. Study on Air Pollution and Lung Diseases in Adults (SAPALDIA) Team. Am J Respir Crit Care Med 155:122–129CrossRefGoogle Scholar
  2. Adam M, Schikowski T, Carsin AE et al (2015) Adult lung function and long-term air pollution exposure. ESCAPE: a multicenter cohort study and meta-analysis. Eur Respir J 45:38–50CrossRefGoogle Scholar
  3. Anderson JO, Thundiyil JG, Stolbach A (2012) Clearing the air: a review of the effects of particulate matter air pollution on human health. J Med Toxicol 8:166–175CrossRefGoogle Scholar
  4. Avol EL, Gauderman WJ, Tan SM, London SJ, Peters JM (2001) Respiratory effects of relocating to areas of differing air pollution levels. Am J Respir Crit Care Med 164:2067–2072CrossRefGoogle Scholar
  5. Bateson TF, Schwartz J (2007) Children’s response to air pollutants. J Toxicol Environ Health 71:238–243CrossRefGoogle Scholar
  6. Boogaard H, Fischer P, Janssen NA, Kos GP, Weijers EP, Cassee FR, van der Zee SC, de Hartog JJ, Meliefste K, Wang M, Brunekreef B, Hoek G (2013) Respiratory effects of a reduction in outdoor air pollution concentrations. Epidemiology 24:753–761CrossRefGoogle Scholar
  7. Burrows B, Cline MG, Knudson RJ, Taussig LM, Lebowitz MD (1983) A descriptive analysis of the growth and decline of the FVC and FEV1. Chest 83:717–724CrossRefGoogle Scholar
  8. Calderón-Garcidueñas L, Mora-Tiscareño A, Ontiveros E (2008) Air pollution, cognitive deficits and brain abnormalities: pilot study with children and dogs. Brain Cogn 68:117–127CrossRefGoogle Scholar
  9. Cesaroni G, Boogaard H, Jonkers S, Porta D, Badaloni C, Cattani G, Forastiere F, Hoek G (2012) Health benefits of traffic-related air pollution reduction in different socioeconomic groups: the effect of low-emission zoning in Rome. Occup Environ Med 69:133–139CrossRefGoogle Scholar
  10. Dales R, Wheeler A, Mahmud M, Frescura AM, Smith-Doiron M, Nethery E, Liu L (2008) The influence of living near roadways on spirometry and exhaled nitric oxide in elementary schoolchildren. Environ Health Perspect 116(10):1423–1427CrossRefGoogle Scholar
  11. Dockery DW, Cunningham J, Damokosh AI, Neas LM, Spengler JD, Koutrakis P, Ware JH, Raizenne M, Speizer FE (1996) Health effects of acid aerosols on North American children: respiratory symptoms. Environ Health Perspect 104:500–505CrossRefGoogle Scholar
  12. Dominici F, Peng RD, Bell ML, Pham L, McDermott A, Zeger SL, Samet JM (2006) Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases. JAMA 10:1127–1134CrossRefGoogle Scholar
  13. Downs SH, Schindler C, Liu S et al (2007) Reduced exposure to PM10 and attenuated age-related decline in lung function. N Engl J Med 357:2338–23347CrossRefGoogle Scholar
  14. European Environment Agency (2015) Air quality in Europe. Accessed 10 Dec 2017
  15. Fanucchi MV, Wong VJ, Hinds D, Tarkington BK, Van Winkle LS, Evans MJ, Plopper CG (2000) Repeated episodes of exposure to ozone alters postnatal development of distal conducting airways in infant rhesus monkeys. Am J Respir Crit Care Med 161:A615CrossRefGoogle Scholar
  16. Fanucchi MV, Day KC, Clay CC, Plopper CG (2004) Increased vulnerability of neonatal rats and mice to 1-nitronaphthalene-induced pulmonary injury. Toxicol Appl Pharmacol 201:53–65CrossRefGoogle Scholar
  17. Gauderman WJ, McConnell R, Gilliland F, London S, Thomas D, Avol E, Vora H, Berhane K, Rappaport EB, Lurmann F, Margolis HG, Peters J (2000) Association between air pollution and lung function growth in southern California children. Am J Respir Crit Care Med 162:1383–1390CrossRefGoogle Scholar
  18. Gauderman WJ, Gilliland GF, Vora H, Avol E, Stram D, McConnell R, Thomas D, Lurmann F, Margolis HG, Rappaport EB, Berhane K, Peters JM (2002) Association between air pollution and lung function growth in southern California children: results from a second cohort. Am J Respir Crit Care Med 166:76–84CrossRefGoogle Scholar
  19. Gauderman WJ, Avol E, Gilliland F, Vora H, Thomas D, Berhane K, McConnell R, Kuenzli N, Lurmann F, Rappaport E, Margolis H, Bates D, Peters J (2004) The effect of air pollution on lung development from 10 to 18 years of age. N Engl J Med 351:1057–1067CrossRefGoogle Scholar
  20. Gauderman WJ, Urman R, Avol E, Berhane K, McConnell R, Rappaport E, Chang R, Lurmann F, Gilliland F (2015) Association of improved air quality with lung development in children. N Engl J Med 372:905–913CrossRefGoogle Scholar
  21. Hoek G, Pattenden S, Willers S et al (2012) PM10, and children’s respiratory symptoms and lung function in the PATY study. Eur Respir J 40:538–547CrossRefGoogle Scholar
  22. Horak F Jr, Studnicka M, Gartner C, Spengler JD, Tauber E, Urbanek R, Veiter A, Frischer T (2002) Particulate matter and lung function growth in children: a 3-yr follow-up study in Austrian schoolchildren. Eur Respir J 19:838–845CrossRefGoogle Scholar
  23. Moshammer H, Hutter HP, Hauck H, Neuberger M (2006) Low levels of air pollution induces changes of lung function in a panel of schoolchildren. Eur Respir J 27:1138–1143CrossRefGoogle Scholar
  24. Nicolai T, Carr D, Weiland SK, Duhme H, von Ehrenstein O, Wagner C, von Mutius E (2003) Urban traffic and pollutant exposure related to respiratory outcomes and atopy in a large sample of children. Eur Respir J 21:956–963CrossRefGoogle Scholar
  25. Nkosi V, Hoek G, Wichmann J, Voyi K (2016) Acute respiratory health effects of air pollution on asthmatic adolescents residing in a community in close proximity to-mine dump in South Africa: Panel study. Int Res J Pub. Environ Health 11:257–269Google Scholar
  26. Perera FP, Tang D, Wang S, Vishnevetsky J, Zhang B, Diaz D, Camann D, Rauh V (2012) Prenatal polycyclic aromatic hydrocarbon (PAH) exposure and child behavior at age 6-7 years. Environ Health Perspect 120(6):921–926CrossRefGoogle Scholar
  27. Raizenne MT, Neas LM, Damokosh AI, Dockery DW, Spengler JD, Koutrakis P, Ware JH, Speizer FE (1996) Health effects of acid aerosols on North American children: pulmonary function. Environ Health Perspect 104:506–514CrossRefGoogle Scholar
  28. Rice MB, Rifas-Shiman SL, Litonjua AA, Oken E, Gillman MW, Kloog I, Luttmann-Gibson H, Zanobetti A, Coull BA, Schwartz J, Koutrakis P, Mittleman MA, Gold DR (2016) Lifetime pollution and lung function in children. Am J Respir Crit Care Med 8:881–888CrossRefGoogle Scholar
  29. Schikowski T, Sugiri D, Ranft U, Gehring U, Heinrich J, Wichmann HE, Kramer U (2005) Long-term air pollution exposure and living close to busy roads are associated with COPD in women. Respir Res 6:152–156CrossRefGoogle Scholar
  30. Schultz ES, Hallberg J, Bellander T, Bergström A, Bottai M, Chiesa F, Gustafsson PM, Gruzieva O, Thunqvist P, Pershagen G, Melén E (2016) Early-life exposure to traffic-related air pollution and lung function up to adolescence. Am J Respir Crit Care Med 193:171–177CrossRefGoogle Scholar
  31. Spyratosa D, Sioutasb C, Tsiotsiosa A, Haidicha AB, Chlorosa D, Triantafylloua G, Sichletidisa L (2015) Effects of particulate air pollution on nasal and lung function development among Greek children: a 19-year cohort study. Int J Environ Health Res 5:480–489CrossRefGoogle Scholar
  32. Suglia SF, Gryparis A, Wright RO, Schwartz J, Wright RJ (2008) Association of black carbon with cognition among children in prospective birth cohort study. Am J Epidemiol 167(3):280–286CrossRefGoogle Scholar
  33. Sunyer J (2009) Lung function effects of chronic exposure to air pollution. Thorax 64:645–646CrossRefGoogle Scholar
  34. Wang X, Dockery DW, Wypij D, Gold DR, Speizer FE, Ware JH, Ferris BG Jr (1993) Pulmonary function growth velocity in children 6 to 18 years of age. Am Rev Respir Dis 148:1502–1508CrossRefGoogle Scholar
  35. Wang S, Zhang J, Zeng X, Zeng Y, Wang S, Chen S (2009) Children’s health association of traffic-related air pollution with children’s neurobehavioral functions in Quanzhou, China. Environ Health Perspect 117:1612–1618CrossRefGoogle Scholar
  36. WHO (2014) World Health Organization global status report on noncommunicable diseases. WHO, Geneva. en.pdf. Accessed 1 June 2017
  37. Zwozdziak A, Sowka I, Willak-Janc E, Zwozdziak J, Kwiecińska K, Balińska-Miśkiewicz W (2016) Influence of PM1 and PM2.5 on lung function variables in healthy schoolchildren – a panel study. Environ Sci Pollut Res 23:23892–23901CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG  2018

Authors and Affiliations

  • A. Dubrowski
    • 1
  • K. Kliś
    • 1
  • M. Żurawiecka
    • 1
  • K. Dereń
    • 1
  • M. Barszcz
    • 1
  • D. Nowakowski
    • 2
  • I. Wronka
    • 1
    Email author
  1. 1.Department of Anthropology, Institute of ZoologyJagiellonian UniversityCracowPoland
  2. 2.Department of AnthropologyWroclaw University of Environmental and Life ScienceWroclawPoland

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