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Obstructive Sleep Apnea and Chronic Kidney Disease

  • Josef YayanEmail author
  • Kurt Rasche
  • Angeliki Vlachou
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1022)

Abstract

Chronic kidney disease (CKD) often accompanies obstructive sleep apnea (OSA). A causative connection of the two disease entities is uncertain. However, eliminating OSA improves the prognosis of CKD patients. In the present study we examined a possible relationship between OSA and CKD, and whether there would be a mutual enhancing interaction in the severity of the two diseases. The study was of a retrospective nature and encompassed 382 patients over the period of 1 January 2014–30 June 2015. The OSA diagnosis was supported by a polysomnographic examination in 363 (95.0%) patients. Blood samples were taken for the determination of kidney function indices. The influence on OSA and CKD of comorbidities also was examined. We found a high probability of a simultaneous occurrence of OSA and CKD; with the odds ratio of 3.94 (95% CI 1.5–10.3%; p = 0.005). The 363 patients with OSA were stratified into 73 (20.1%) mild, 98 (27.0%) moderate, and 192 (52.9%) severe OSA cases according to the apnea-hypopnea index. CKD was found in 43 (58.9%) patients with mild OSA, 73 (74.5%) with moderate OSA, and 137 (71.4%) with severe OSA. Most OSA patients also suffered from hypertension and obesity. For comparison, CKD was detected in 7 (36.8%) out of the 19 patients without OSA (p < 0.003). We conclude that CKD develops significantly more often in patients with OSA than in those without it, and CKD frequency increases with the severity of OSA.

Keywords

Apnea-hypopnea index Chronic kidney insufficiency Comorbidities Obstructive sleep apnea Renal function 

Notes

Conflicts of Interest

The authors declare no competing interests in relation to this article.

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Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  1. 1.Department of Internal Medicine, Division of Pulmonary, Allergy and Sleep Medicine, HELIOS Clinic WuppertalWitten/Herdecke UniversityWuppertalGermany

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