Hypertension Is a Risk Factor for Several Types of Heart Disease: Review of Prospective Studies

  • Yoshihiro KokuboEmail author
  • Chisa Matsumoto
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 956)


Many prospective cohort studies have demonstrated that hypertension is a strong risk factor for total mortality and cardiovascular disease (CVD). Heart disease includes coronary heart disease (CHD), heart failure, atrial fibrillation, valvular disease, sudden cardiac death (SCD), sick sinus syndrome (SSS), cardiomyopathy, and aortic aneurysms. Most of the epidemiologic prospective studies of heart disease focused on coronary/ischemic heart disease. Here we comprehensively reviewed the association between hypertension and the above-mentioned heart diseases. We found that CHD, heart failure, atrial fibrillation, aortic valvular disease, SCD, SSS, left ventricular hypertrophy, and abdominal aortic aneurysms were all associated with hypertension. Those relations tended to be stronger in men. The prevention of hypertension and lowering one’s blood pressure may help reduce the risk of developing heart disease.


Heart disease Hypertension Prospective studies Epidemiology Risk factors 


Source of Funding

This work was supported by the Intramural Research Fund of the National Cerebral and Cardiovascular Center, by the Japan Agency for Medical Research and development, AMED (15gk0210001h0101), and by a Grant-in-Aid for Scientific Research (B, No. 16H05252) and Challenging Exploratory Research (No. 16K15365) in Japan.


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Copyright information

© Springer International Publishing AG 2016

Authors and Affiliations

  1. 1.Department of Preventive CardiologyNational Cerebral and Cardiovascular CenterSuitaJapan
  2. 2.Department of Clinical EpidemiologyHyogo College of MedicineNishinomiyaJapan

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