Breathing in Parkinsonism in the Rat

  • Monika Bialkowska
  • Paweł Boguszewski
  • Mieczyslaw Pokorski
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 884)

Abstract

Parkinsonism is underlain by dopamine (DA) deficiency in the mid-brain, a neurotransmitter innately involved with respiratory regulation. However, the state of respiration in parkinsonism is an unsettled issue. In this study we seek to determine ventilation and its responses to hypoxia in a reserpine – alpha-methyl-tyrosine model of parkinsonism in the rat. We also attempted to differentiate between the role of discrete brain and carotid body DA stores in the modulation of the hypoxic ventilatory response (HVR). To this end we used domperidone, a peripheral D2 receptor antagonist, and levodopa, a central D2 receptor agonist. The HVRs to acute 12 % and 8 % hypoxia were studied in a whole body plethysmograph in the same rats before and after the induction of parkinsonic symptoms in conscious rats. We found that resting ventilation and the HVR were distinctly reduced in parkinsonism. The reduction was particularly evident in the peak hypoxic hyperpneic augmentation. Domperidone, which enhanced ventilation in the control healthy condition, failed to reverse the reduced parkinsonic HVR. In contrast, levodopa, which did not appreciably affected ventilation in the healthy condition, caused the parkinsonic HVR to return to and above the baseline healthy level. The findings demonstrate the predominance of a lack of the central DA stimulatory element and minimize the role of carotid body DA in the ventilatory impediment of parkinsonism. In conclusion, the study provides the pathophysiological savvy concerning the respiratory insufficiency of parkinsonism, a sequela which carries a risk of chronically impaired blood oxygenation, which may drive the disease worsening.

Keywords

Domperidone Dopamine Hypoxic ventilatory response Levodopa Parkinsonism Reserpine Ventilation 

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Monika Bialkowska
    • 1
  • Paweł Boguszewski
    • 2
  • Mieczyslaw Pokorski
    • 3
  1. 1.Department of Human Physiology, Faculty of Medicine, The Ludwik Rydygier Collegium Medicum in BydgoszczNicolaus Copernicus University in TorunBydgoszczPoland
  2. 2.Laboratory of Limbic System, Department of NeurophysiologyThe Nencki Institute of Experimental Biology, Polish Academy of SciencesWarsawPoland
  3. 3.Public Higher Medical Professional School in OpoleInstitute of NursingOpolePoland

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