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Inflammatory Activity in Autism Spectrum Disorder

  • I. Tonhajzerova
  • I. Ondrejka
  • M. Mestanik
  • P. Mikolka
  • I. Hrtanek
  • A. Mestanikova
  • I. Bujnakova
  • D. Mokra
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 861)

Abstract

Autism spectrum disorder (ASD) is a severe neurodevelopmental disorder in early childhood characterized by impairment in communication and behavior. Recent research is focused on the immune dysregulation as a potential pathomechanism leading to ASD. Thus, we addressed the hypothesis that inflammatory activity might be enhanced in children suffering from ASD. We examined 15 children with ASD (13 boys/2 girls, mean age of 9.3 ± 0.7 years) and 20 age/gender-matched healthy subjects as a control group. All children were medication free and in good health. Hematological parameters in venous blood and plasma levels of pro-inflammatory cytokines - tumor necrosis factor alpha (TNF-α), interleukin 1ß (IL-1ß), and interleukin 8 (IL-8) – were assessed in each subject using human ultra-sensitive ELISA kits. In addition, TBARS as a marker of oxidative stress was evaluated. We found that the level of IL-8 was significantly increased in the ASD children, whereas the other markers remained unappreciably changed compared to controls (p = 0.003). In conclusion, the study demonstrates a discrete immune dysfunction in ASD of pro-inflammatory character.

Keywords

Autism Childhood Cytokines Immune dysfunction Neurodevelopment 

Notes

Acknowledgments

This work was supported by National Research Grant VEGA 1/0087/14, APVV-0254-11 and BioMed Martin (ITMS: 26220220187). The project was co-financed by the European Union.

Conflicts of Interest

The authors declare no conflicts of interest in relation to this article.

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • I. Tonhajzerova
    • 1
  • I. Ondrejka
    • 2
  • M. Mestanik
    • 1
  • P. Mikolka
    • 1
  • I. Hrtanek
    • 2
  • A. Mestanikova
    • 1
  • I. Bujnakova
    • 1
  • D. Mokra
    • 1
  1. 1.Department of Physiology, Jessenius Faculty of Medicine in MartinComenius University in BratislavaMartinSlovakia
  2. 2.Clinic of Psychiatry, Jessenius Faculty of Medicine in MartinComenius University in Bratislava, Martin University HospitalMartinSlovakia

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