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Evaluation of Volumetric Changes in Differential Diagnosis of Brain Atrophy and Active Hydrocephalus

  • E. Szczepek
  • L. Czerwosz
  • K. Nowiński
  • J. Jurkiewicz
  • Z. Czernicki
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 840)

Abstract

Despite a variety of diagnostic methods, differentiation of symptoms of normal pressure hydrocephalus from those of atrophic processes of the brain is still a difficult task. In the present study an attempt of non-invasive differential diagnosis of normal pressure hydrocephalus (NPH) and brain atrophy (BA) was presented using volumetric analysis of CT images of the head by means of VisNow proprietary software. The analysis was based on the number of voxels converted to the amount of cerebrospinal fluid (CSF) in the subarachnoid space, skull base casters, and the ventricular system. The results demonstrate that the mean volumes of CSF in these compartments in patients with NPH differed significantly from those in BA. Similarly, the mean volumes of CSF in the subarachnoid space and skull base casters in patients with BA differed significantly from those in NPH. Volumetric assessment presented in the paper by application of VisNow software seems useful in the evaluation of NPH and brain BA.

Keywords

Cerebral atrophy Cerebrospinal fluid volume Normal pressure hydrocephalus Volumetric assessment 

Notes

Acknowledgments

The research support was partially provided by the Biocentrum-Ochota project POIG.02.03.00-00-003/09.

Conflicts of Interest

The authors declare no conflicts of interest in relation to this article.

References

  1. Ambarki K, Wahlin A, Birgander R, Eklund A, Malm J (2011) MR imaging of brain volumes: evaluation of a fully automatic software. Am J Neuroradiol 32:408–412PubMedCrossRefGoogle Scholar
  2. Borucki B, Nowiński K, Chlebiej M, Rutkowski A, Adamczyk P, Laskowski JM (2011) Automated geometric features evaluation method for normal foot skeleton model. Int J Comput Assist Radiol Surg 1:110–111Google Scholar
  3. Borucki B, Nowiński K, Adamczyk P, Laskowski JM (2012) Automatic classification of hallux valgus deformations with the use of automatic evaluation of geometric descriptors. Int J Comput Assist Radiol Surg 1:196–198Google Scholar
  4. Czernicki Z, Jurkiewicz J (1991) Disorders of intracranial volume relations – pressure. Pol J Neurol Neurosurg 25:671–677Google Scholar
  5. Czernicki Z, Walecki J, Jurkiewicz J, Grochowski W, Tychmanowicz K (1992) Intracranial volume reserve determination using CT images, numerical analysis and lumbar infusion tests. An experimental study. Acta Neurochir 115:43–46PubMedCrossRefGoogle Scholar
  6. Czerwosz L, Szczepek E, Sokołowska B, Jurkiewicz J, Czernicki Z (2008) Recognition of gait disturbances in patients with normal pressure hydrocephalus using a computer dynography system. J Physiol Pharmacol 59(Suppl 6):201–207PubMedGoogle Scholar
  7. Czerwosz L, Szczepek E, Sokołowska B, Jurkiewicz J, Czernicki Z (2012) Recognition of posture and gait disturbances in patients with normal pressure hydrocephalus using a posturography and computer dynography systems. InTech, Chapter 12, pp 189–214Google Scholar
  8. Czerwosz L, Szczepek E, Sokołowska B, Jurkiewicz J, Czernicki Z (2013) Posturography in differential diagnosis of normal pressure hydrocephalus and brain atrophy. Adv Exp Med Biol 755:311–324PubMedCrossRefGoogle Scholar
  9. Fersten E, Łuczywek E, Jurkiewicz J, Dowżenko A (1997) Evaluation of perceptive activity in persons with low pressure hydrocephalus treated surgically. Pol J Neurol Neurosurg 31:77–88Google Scholar
  10. ICM – Interdisciplinary Center of Mathematical and Computational Modeling (2011). http://visnow.icm.edu.pl. Accessed 12 Nov 2013
  11. Ishii K, Soma T, Shimada K, Oda H, Terashima A, Kawasaki R (2013) Automatic volumetry of the cerebrospinal fluid space in idiopathic normal pressure hydrocephalus. Dement Geriatr Cogn Disord Extra 3:489–496CrossRefGoogle Scholar
  12. Juniewicz H, Kasprowicz M, Czosnyka M, Czosnyka Z, Gizewski S, Dzik M, Pickard JD (2005) Analysis of intracranial pressure during and after the infusion test in patients with communicating hydrocephalus. Physiol Meas 26:1039–1048PubMedCrossRefGoogle Scholar
  13. Jurkiewicz J (1996) Negative-pressure hydrocephalus. J Neurosurg 85:364–365PubMedGoogle Scholar
  14. Kapiński N, Borucki B, Nowiński K (2013) Error assessment and minimization in 4D motion tracking for functional orthopaedics diagnostics. Int J Comput Assist Radiol Surg 8:157–159Google Scholar
  15. Marszałek P, Jurkiewicz J, Fersten E, Łuczywek E, Czernicki Z, Gielecki J, Bogucki J (1997) Multi-stage method for the diagnosis of low-pressure hydrocephalus. Pol J Neurol Nuerosurg 31:527–539Google Scholar
  16. Szczepek E, Czerwosz L, Dąbrowski P, Dudziński K, Jurkiewicz J, Czernicki Z (2008) Posturography and computerized gait analysis in the computer dynography system as non-invasive methods for evaluation of normal pressure hydrocephalus progression. Pol J Neurol Nuerosurg 42:139–152Google Scholar

Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • E. Szczepek
    • 1
    • 2
    • 3
  • L. Czerwosz
    • 3
    • 4
  • K. Nowiński
    • 5
  • J. Jurkiewicz
    • 1
  • Z. Czernicki
    • 1
    • 2
  1. 1.Department of Neurosurgery, Second Faculty of MedicineMedical University of WarsawWarsawPoland
  2. 2.Department of Neurosurgery, Medical Research CenterPolish Academy of SciencesWarsawPoland
  3. 3.Bioinformatics Laboratory, Medical Research CenterPolish Academy of SciencesWarsawPoland
  4. 4.Department of Respiratory Research, Medical Research CenterPolish Academy of SciencesWarsawPoland
  5. 5.Interdisciplinary Center for Mathematical and Computational ModellingWarsaw UniversityWarsawPoland

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