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Etiological Factors Causing Lower Respiratory Tract Infections Isolated from Hospitalized Patients

  • A. Guzek
  • Z. Rybicki
  • K. KorzeniewskiEmail author
  • K. Mackiewicz
  • E. Saks
  • A. Chciałowski
  • E. Zwolińska
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 835)

Abstract

Lower respiratory tract infections (LRTI) account for 20–30 % of all hospital-acquired contagions. They are characterized by high mortality of hospitalized patients. The most serious form of LRTI is pneumonia, and the most common etiological factors in such cases are bacteria. The article gives the analysis of bacterial flora samples obtained from lower respiratory tract of hospitalized patients. In vitro susceptibility of pathogens to selected antibiotics has also been assessed. We carried out a retrospective analysis of 1,171 bacterial strains isolated from 1,171 patients treated in clinics of the Military Institute of Medicine in Warsaw, Poland. In most cases the samples were collected from an endotracheal or tracheostomic tube (71.5 %) and from bronchoalveolar lavage (21.7 %). The most commonly isolated pathogens included Acinetobacter baumannii (35.8 %), Staphylococcus aureus (27.6 %), Klebsiella pneumoniae (19.4 %), and Pseudomonas aeruginosa (16.2 %). Multidrug-resistant gram-negative bacteria exhibited 100 % susceptibility to colistin only. Klebsiella pneumoniae ESBL+ and Acinetobacter baumannii were most susceptible to carbapenems, while Pseudomonas aeruginosa strains to ceftazidime. Methicillin-resistant Staphylococcus aureus were 100 % susceptible to vancomycin, linezolid, and tigecycline. In conclusion, identifying the etiological factors causing infections of the lower respiratory tract and determining their drug-susceptibility is of key importance in empirical treatment.

Keywords

Antibiotics Hospital treatment Respiratory infection Susceptibility 

Notes

Acknowledgments

We thank Dr. Andrzej Truszczyński from the Clinic of Anesthesiology and Intensive Care of the Military Institute of Medicine in Warsaw for his support during collecting the data. This work was supported by the Polish Ministry of Science and High Education (Theme no. 222/213, Military Institute of Medicine in Warsaw, Poland).

Conflicts of Interest

The authors declare no conflict of interest in relation to this article.

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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • A. Guzek
    • 1
  • Z. Rybicki
    • 2
  • K. Korzeniewski
    • 3
    Email author
  • K. Mackiewicz
    • 1
  • E. Saks
    • 1
  • A. Chciałowski
    • 4
  • E. Zwolińska
    • 5
  1. 1.Department of Medical DiagnosticsMilitary Institute of MedicineWarsawPoland
  2. 2.Clinic of Anesthesiology and Intensive CareMilitary Institute of MedicineWarsawPoland
  3. 3.Department of Epidemiology and Tropical MedicineMilitary Institute of MedicineGdyniaPoland
  4. 4.Department of ScienceMilitary Institute of MedicineWarsawPoland
  5. 5.Department of ObstetricsSt Family Maternity HospitalWarsawPoland

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