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Fatigue in Sarcoidosis and Exercise Tolerance, Dyspnea, and Quality of Life

  • D. JastrzębskiEmail author
  • D. Ziora
  • M. Lubecki
  • K. Zieleźnik
  • M. Maksymiak
  • J. Hanzel
  • A. Początek
  • A. Kolczyńska
  • L. Nguyen Thi
  • A. Żebrowska
  • J. Kozielski
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 833)

Abstract

Fatigue is one of the major symptoms reported by sarcoidosis patients. The relationship between fatigue and clinical course of sarcoidosis remains unclear. The aim of the study was to evaluate the relationship between fatigue and lung function tests, exercise tolerance, dyspnea, and quality of life among sarcoidosis patients. One hundred eleven sarcoidosis patients completed the following questionnaires: Fatigue and Assessment Scale (FAS), Quality of Life Scale (SF-36), and dyspnea scales: Medical Research Council Questionnaire, Baseline Dyspnea Index, and Oxygen Cost Diagram. Clinical parameters (FVC, FEV1, DLCO, VO2, and VO2/AT, and work load) were derived from the patients’ medical files. The exercise tolerance was the only clinical parameter associated with fatigue (Max. Work Load −0.65, VO2 −0.42, VO2/AT −0.51). No correlations were found between FAS and spirometry or diffusing tolerance. Fatigue correlated with all dyspnea domains by means of (r values ranging from 0.47 to 0.77 in multivariate regression analysis) and with quality of life in SF-36 questionnaire (r values ranging from −0.33 to −0.83). We conclude that FAS seems a reliable and valid indicator of dyspnea level, quality of life, and exercise tolerance in sarcoidosis patients.

Keywords

Dyspnea Exercise ability Fatigue Lung function tests Quality of life Sarcoidosis 

Notes

Acknowledgments

This study was supported by grant no. KNW-1-025/D/2/0 from the Medical University of Silesia, Poland.

Conflicts of Interest

The authors declare no conflicts of interest in relation to this article.

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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • D. Jastrzębski
    • 1
    Email author
  • D. Ziora
    • 1
  • M. Lubecki
    • 1
  • K. Zieleźnik
    • 1
  • M. Maksymiak
    • 1
  • J. Hanzel
    • 1
  • A. Początek
    • 1
  • A. Kolczyńska
    • 1
  • L. Nguyen Thi
    • 1
  • A. Żebrowska
    • 2
  • J. Kozielski
    • 1
  1. 1.School of Medicine with the Division of Dentistry, Department of Lung Diseases and TuberculosisMedical University of SilesiaZabrzePoland
  2. 2.Department of Physiology and Medicine of SportAcademy of Physical EducationKatowicePoland

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