Molecular Genetics of Recombination

Volume 17 of the series Topics in Current Genetics pp 381-442


Meiotic recombination

  • Neil HunterAffiliated withSections of Microbiology and Molecular & Cellular Biology, University of California Davis Email author 

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Crossover recombination is essential for homolog segregation during meiosis. In contrast to spontaneous mitotic recombination, meiotic recombination is intrinsic being initiated by the programmed formation of DNA double-strand-breaks. In addition, the tendencies of the core recombination machinery to utilize a sister-chromatid template and to produce a noncrossover outcome are counteracted by meiosis-specific factors, which ultimately ensure the formation of at least one crossover per homolog.