Photo-Controlled Release of NO and CO with Inorganic and Organometallic Complexes

Part of the Structure and Bonding book series (STRUCTURE, volume 165)


The photochemical delivery of bioactive small molecules to physiological targets provides the opportunity to control the location, timing, and dosage of such delivery. We will discuss recent developments of the synthesis and studies of various metal complexes designed for targeted release of the bioregulatory diatomics nitric oxide and carbon monoxide. Of considerable interest are those systems where the NO or CO precursor and/or the photochemical product is luminescent such that imaging techniques allow one to identify the release location.


Carbon monoxide Luminescence Near-infrared excitation Nitric oxide PhotoCORM PhotoNORM Photoreaction 



4-Vinyl pyridine


2-Aminofluorene chromophores


Boron dipyrromethane difluoride




Palladium dimeric complex


Carbon monoxide releasing moiety


Carbon monoxide sensitive biosensor


Circularly permuted yellow fluorescent protein


trans-CrIII(Cyclam)(ONO)2 +


1,4,8,11 Tetraazacyclotetradecane


Density functional theory








Dulbecco’s phosphate buffered saline




Electron paramagnetic resonance


Excited state


Fluorescein ethyl ester




Förster resonance energy transfer












Heme oxygenase


Incident light intensity


Intensity of light absorbed


Inactive CORM






Lactate dehydrogenase


Ligand field


Tripodal polypyridine ligands






Metal to ligand charge transfer


Near infrared


Nuclear magnetic resonance


Nitric oxide analyzer








Polyethylene glycol


Poly(2-hydroxyethyl methacrylate)


Photo-activated CO releasing moiety


Photo-activated NO releasing moiety












Quantum dot


Roussin’s black salts




Roussin’s red salts


Roussin’s red esters
















Time-dependent density functional theory












Two-photon excitation




Tris(sulfonatophenyl)phosphine trianion


Upconverting nanoparticle





This work was supported by a grant to PCF (CHE-1058794) from the US National Science Foundation, by a fellowship to AEP from the UCSB Partnership for International Research and Education in Electron Chemistry and Catalysis at Interfaces (NSF grant OISE-0968399).


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Chemistry and BiochemistryUniversity of California, Santa BarbaraSanta BarbaraUSA
  2. 2.Department of Chemistry and Center for Photochemical SciencesBowling Green State UniversityBowling GreenUSA

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