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The Role of TNF in Cancer

  • Harald Wajant
Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 49)

Abstract

Tumor necrosis factor (TNF) is an extraordinarily pleiotropic cytokine with a central role in immune homeostasis, inflammation, and host defense. Dependent on the cellular context, it can induce such diverse effects as apoptosis, necrosis, angiogenesis, immune cell activation, differentiation, and cell migration. These processes are of great relevance in tumor immune surveillance, and also play crucial roles in tumor development and tumor progression. It is therefore no surprise that TNF in a context-dependent manner displays pro- and antitumoral effects. Modulation of the activity of the TNF–TNF receptor system thus offers manifold possibilities for cancer therapy. In fact, TNF in combination with melphalan is already an established treatment option in the therapy of advanced soft tissue sarcoma of the extremities and many preclinical data suggest that TNF neutralization could also be exploited to fight cancer or cancer-associated complications.

Keywords

Tumor Necrosis Factor Tumor Necrosis Factor Receptor Isolate Limb Perfusion Transient Receptor Potential Channel Vanilloid Tumor Necrosis Factor Receptor Superfamily 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

AOM

Azoxymethane

APC

Antigen presenting cell

COX-2

Cyclo-oxygenase-2

cIAP1/2

Cellular inhibitor of apoptosis protein-1/2

DMBA

7,12-di-methylbenz[α]-anthracene

DSS

Dextran sulfate sodium salt

EMT

Epithelial–mesenchymal transition

ERK

Extracellular-regulated kinase

FADD

Fas-associated death domain

GSK3β

Glycogen synthase kinase

ILP

Isolated limb perfusion

JNK

cJun N-terminal kinase

LMCV

Lymphocytic choriomeningitis virus

MCA

3′-Methylcholanthrene

MCP1

Monocyte chemoattractant protein-1

MDR2

Multidrug resistance p-glycoprotein 2

MMP-9

Matrix metalloprotease-9

OA

Ocadaic acid

PDAC

Pancreatic ductal adenocarcinoma

p38 MAPK

p38 mitogen-activated protein (MAP) kinase

RANK

Receptor activator of NF-kappaB

TPA

12-0-Tetradecanoyl-phorbol-13-acetate

TRPV1

Transient receptor potential channel vanilloid type 1

VEGFR2

Vascular endothelial growth factor (VEGF) receptor

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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  1. 1.Department of Molecular MedicineMedical Clinic and Polyclinic II, University of WürzburgWuerzburgGermany

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