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Immune-Mediated CNS Damage

  • Katrin Kierdorf
  • Yiner Wang
  • Harald Neumann
Chapter
Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 51)

Abstract

Multiple sclerosis (MS) is a demyelinating autoimmune disease. However, the persisting neurological deficits in MS patients result from acute axonal injury and chronic neurodegeneration, which are both triggered by the autoreactive immune response. Innate immunity, mainly mediated by activated microglial cells and invading macrophages, appears to contribute to chronic neurodegeneration. Activated microglia produce several reactive oxygen species and proinflammatory cytokines which affect neuronal function, integrity and survival. Adaptive immunity, particularly in cytotoxic CD8+ T cells, participates in acute demyelination and axonal injury by directly attacking oligodendrocytes and possibly neurons as well. Understanding the mechanisms of immune-mediated neuronal damage might help to design novel therapy strategies for MS.

Keywords

Multiple Sclerosis Experimental Autoimmune Encephalomyelitis Multiple Sclerosis Patient Major Histocompatibility Complex Class NADPH Oxidase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The group of H.N. is supported by the Hertie Foundation, the Rose Foundation, the Deutsche Forschungsgemeinschaft and the European Union (LSHM-CT-2005–018637). The Neural Regeneration Group at the University Hospital Bonn is supported by the Hertie-Foundation, the Walter-und-Ilse-Rose-Foundation, the DFG (KFO177, SFB704) and the EU (LSHM-CT-2005-018637).

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© Springer Berlin Heidelberg 2009

Authors and Affiliations

  1. 1.Institute of Reconstructive NeurobiologyUniversity Bonn LIFE and BRAIN Center, University Bonn and Hertie-FoundationBonnGermany

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