The NPB/NPW Neuropeptide System and Its Role in Regulating Energy Homeostasis, Pain, and Emotion

  • Mari Hondo
  • Makoto Ishii
  • Takeshi Sakurai
Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 46)


Neuropeptide B (NPB) and neuropeptide W (NPW) are neuropeptides that were recently identified as endogenous ligands for the previously orphan G-protein coupled receptors, GPR7 (NPBWR1) and GPR8 (NPBWR2). This neuropeptide system is thought to have a role in regulating feeding behavior, energy homeostasis, neuroendocrine function, and modulating inflammatory pain. Strong and discrete expression of their receptors in the extended amygdala suggests a potential role in regulating stress responses, emotion, anxiety and fear; however, there have been no functional studies to date to support this possibility. Future studies of NPB/NPW using both pharmacological and phenotypic analysis of genetically engineered mice will lead to further elucidation of the physiological role of this novel neuropeptide system.


Ventral Tegmental Area Spinal Dorsal Horn Extended Amygdala Physiol Regul Integr Comp Regulate Feeding Behavior 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  1. 1.Department of Molecular Neuroscience and Integrative Physiology, Graduate School of Medical ScienceKanazawa UniversityKanazawa, IshikawaJapan
  2. 2.Yanagisawa Orphan Receptor Project, ERATOJapan Science and Technology AgencyTokyoJapan

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