Orphan G Protein-Coupled Receptors and Novel Neuropeptides

Volume 46 of the series Results and Problems in Cell Differentiation pp 57-88


Prolactin-Releasing Peptide

  • Steven H. LinAffiliated withDepartment of Radiation Oncology and Molecular Radiation Sciences,Sydney Kimmel Comprehensive Cancer Center, The Johns Hopkins Hospital Email author 

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Prolactin-releasing peptide (PrRP) was initially isolated from the bovine hypothalamus as an activating component that stimulated arachidonic acid release from cells stably expressing the orphan G protein-coupled receptor hGR3 (Hinuma et al. 1998) [also known as GPR10 (Marchese et al. 1995), or UHR-1 for the rat orthologue (Welch et al. 1995)]. Initially touted as a prolactin-releasing factor (therefore aptly named prolactin-releasing peptide), the perspective on the function of this peptide in the organism has been greatly expanded. Over 120 papers have been published on this subject since its initial discovery in 1998. Herein I review the state of knowledge of the PrRP system, its putative function in the organism, and implications for therapy.