Bioenergetics pp 253-278

Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 45)

A Structural Perspective on Mechanism and Function of the Cytochrome bc1 Complex

  • Carola Hunte
  • Sozanne Solmaz
  • Hildur Palsdóttir
  • Tina Wenz
Chapter

Abstract

The cytochrome bc1 complex is a fundamental component of the energy conversion machinery of respiratory and photosynthetic electron transfer chains. The multi-subunit membrane protein complex couples electron transfer from hydroquinone to cytochrome c to the translocation of protons across the membrane, thereby substantially contributing to the proton motive force that is used for ATP synthesis. Considerable progress has been made with structural and functional studies towards complete elucidation of the Q cycle mechanism, which was originally proposed by Mitchell 30 years ago. Yet, open questions regarding key steps of the mechanism still remain. The role of the complex as a major source of reactive oxygen species and its implication in pathophysiological conditions has recently gained interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • Carola Hunte
    • 1
  • Sozanne Solmaz
    • 1
  • Hildur Palsdóttir
    • 1
  • Tina Wenz
    • 1
  1. 1.Dept. Molecular Membrane BiologyMax Planck Institute of BiophysicsFrankfurtGermany

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