NPY in alcoholism and psychiatric disorders

  • Annika Thorsell
  • Rose-Marie Karlsson
  • Markus Heilig
Part of the Experientia Supplementum book series (EXS, volume 95)


The NPY system may well be one of the most interesting target systems for development of treatments for alcohol dependence as well as mood disorders such as depression and anxiety syndromes. NPY is an endogenous anxiolytic compound, functions as an antidepressant, and is effective in modifying alcohol intake in high drinking states. Through receptor subtype specific compounds, the NPY system offers an interesting and innovative future approach for treatment designs. Selective Y2 receptor antagonists and/or Y1 agonists that are peripherally available and effectively penetrate the CNS are possible candidates. In conclusion, the NPY system offers attractive targets for development of future treatments for depression, anxiety, and alcohol dependence.


Ethanol Intake Alko Alcohol High Alcohol Drinking Dorsal Periaqueductal Gray Matter Electroconvulsive Stimulus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Verlag/Switzerland 2006

Authors and Affiliations

  • Annika Thorsell
    • 1
  • Rose-Marie Karlsson
    • 1
  • Markus Heilig
    • 1
  1. 1.NIH/NIAAA, LCSBethesdaUSA

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