Biosynthesis pp 93-142

Part of the Topics in Current Chemistry book series (volume 195)

Cofactor Biosynthesis: A Mechanistic Perspective

  • Tadhg P. Begley
  • Cynthia Kinsland
  • Sean Taylor
  • Manish Tandon
  • Robb Nicewonger
  • Min Wu
  • Hsiu-Ju Chiu
  • Neil Kelleher
  • Nino Campobasso
  • Yi Zhang
Chapter

Abstract

The chemistry of the cofactors has provided a fertile area of overlap between organic chemistry and biochemistry, and the organic chemistry of the cofactors is now a thoroughly studied area. In contrast, the chemistry of cofactor biosynthesis is still relatively underdeveloped. In this review the biosynthesis of nicotinamide adenine dinucleotide, riboflavin, folate, molyb-dopterin, thiamin, biotin, lipoic acid, pantothenic acid, coenzyme A, S-adenosylmethionine, pyridoxal phosphate, ubiquinone and menaquinone in E. coli will be described with a focus on unsolved mechanistic problems.

Keywords

Cofactor vitamin E. coli biosynthesis mechanism 

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Copyright information

© Springer Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Tadhg P. Begley
    • 1
  • Cynthia Kinsland
    • 1
  • Sean Taylor
    • 1
  • Manish Tandon
    • 1
  • Robb Nicewonger
    • 1
  • Min Wu
    • 1
  • Hsiu-Ju Chiu
    • 1
  • Neil Kelleher
    • 1
  • Nino Campobasso
    • 1
  • Yi Zhang
    • 1
  1. 1.Department of ChemistryCornell UniversityIthacaUSA

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