A Model of Axis Determination for the Drosophila Wing Disc

  • Koji Kyoda
  • Hiroaki Kitano
Part of the Lecture Notes in Computer Science book series (LNCS, volume 1674)


In this paper we propose a comprehensive model of axis determination for the Drosophila wing disc, and we simulate spatio-temporal gene expression patterning in the Drosophila wing disc. The role of interaction among several genes involved has been analyzed systematically in this simulation. The results illustrate that successful reconstruction of the gene expression patterns observed in the actual wing disc requires several hypothetical gene regulations. Above all, we predict the possible existence of a diffusive factor responsible for formation of the D-V boundary in the Drosophila wing disc.


Wing Disc Diffusive Factor Drosophila Wing Dorsal Compartment Axis Determination 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • Koji Kyoda
    • 1
    • 2
  • Hiroaki Kitano
    • 1
    • 3
  1. 1.Kitano Symbiotic Systems ProjectERATO, JSTTokyoJapan
  2. 2.Department of Computer ScienceKeio UniversityYokohamaJapan
  3. 3.Sony Computer Science Laboratories Inc.TokyoJapan

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