Particle Stress in Bioreactors

  • Hans-Jürgen Henzler
Chapter
Part of the Advances in Biochemical Engineering/Biotechnology book series (ABE, volume 67)

Abstract

In many biological processes, e.g. the fermentation of cells and sensitive microorganisms or bioconversion with immobilised enzymes, low shear stress is of crucial importance for the optimal course of processes.

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References

  1. 1.
    Liepe F (1988) Verfahrenstechnische Berechnungsmethoden. Part 4, VCH, WeinheimGoogle Scholar
  2. 2.
    Kolmogoroff A (1958) Collected works on the statistical theory of turbulence. Akademic Verlag, BerlinGoogle Scholar
  3. 3.
    Middler M, Finn K (1966) Biotech Bioeng 8:71CrossRefGoogle Scholar
  4. 4.
    Tramper J, Willams JB, Joustra B, Vlak JM (1986) Enzym Microb Technol 8:33CrossRefGoogle Scholar
  5. 5.
    Smith G, Greenfield F, Randerson D (1987) Biotechnol Techniques 1:39CrossRefGoogle Scholar
  6. 6.
    Goldblum S, Bae Y, Hink WF, Calmers JJ (1990) Biotechol Prog 6:383CrossRefGoogle Scholar
  7. 7.
    Dunlop EH, Namdev PK, Rosenberg MZ (1994) Chemical Engineering Science 49:2263CrossRefGoogle Scholar
  8. 8.
    Augstein DC, Sinskey AJ, Wang DIC (1971) Biotechnol Bioeng 13:409CrossRefGoogle Scholar
  9. 9.
    Reese ET, Ryu DY (1980) Enzym Microb Technol 2:239CrossRefGoogle Scholar
  10. 10.
    Strathopulos NA, Hellums JD (1980) Biotechnol Bioeng 27:1021CrossRefGoogle Scholar
  11. 11.
    Ludwig A, Kretzmer G (1992) Enzyme Microb Technol 14:209CrossRefGoogle Scholar
  12. 12.
    Märkl H, Bronnemeier R (1982) Biotech Bioeng 24:553CrossRefGoogle Scholar
  13. 13.
    Loughlin PFM, Malone DM, Murtagh JT, Kieran PM (1998) Biotech Bioeng 58:595CrossRefGoogle Scholar
  14. 14.
    Sumino Y, Akiyama S, Fukuda H (1972) J Ferment Technol 50:203Google Scholar
  15. 15.
    Kato Y, Hiraoka S, Tada Y, Shirai S, Ue T, Koh ST, Yamaguchi T (1995) Kogaku-Ronbunshu 21(2):365Google Scholar
  16. 16.
    Kato Y, Hiraoka S, Tada Y, Koh ST, Lee YS (1996) Trans Ichem E 74:451Google Scholar
  17. 17.
    Büchs J, Maier U, Milbradt C, Toels B (1999) submitted Biotech and BioengGoogle Scholar
  18. 18.
    Henzler HJ, Schedel M (1991) Bioprocess Engineering 7:123CrossRefGoogle Scholar
  19. 19.
    Zoels B (1992) Quantifizierung und Optimierung der Screening-Bedingungen im Schüttelkolben Master Thesis Fachhochschule MannheimGoogle Scholar
  20. 20.
    Henzler HJ (1978) Homogenisieren von Flüssigkeiten und Gasen. VDI-Forschungsheft 587Google Scholar
  21. 21.
    Judat H (1976) Dissertation, Universität BerlinGoogle Scholar
  22. 22.
    Henzler HJ (1982) Chem Ing Tech 54:461CrossRefGoogle Scholar
  23. 23.
    Henzler HJ (1998) Mischen und Rühren. GVC-Tagung Baden-BadenGoogle Scholar
  24. 24.
    Möckel HO (1978) Dissertation, Technische Hochschule, KöthenGoogle Scholar
  25. 25.
    Laufhütte HD(1986) Dissertation, TU MünchenGoogle Scholar
  26. 26.
    Geissler RK (1991) Dissertation, TU MünchenGoogle Scholar
  27. 27.
    Henzler HJ, Biedermann A (1996) Chem Ing Tech 68:1546CrossRefGoogle Scholar
  28. 28.
    Henzler HJ, Kauling J (1993) Bioprocess Engineering 9:61CrossRefGoogle Scholar
  29. 29.
    Aunins, Henzler HJ (1993) Aeration in Cell Culture Bioreactors. In: Rehm HJ, Reed G, Pühler A Stadler P Biotechnology VCH 3:219Google Scholar
  30. 30.
    Handa A, Emery AN, Spier RE (1987) Develop Biol Stand 66:241Google Scholar
  31. 31.
    Handa-Corrigan A, Emercy AN, Spier RE (1989) Enzyme MicrobTechnol 11:230CrossRefGoogle Scholar
  32. 32.
    Newitt DM, Dombrowski N, Knelman FH (1954) Trans Instn Chem Engrs 32:244Google Scholar
  33. 33.
    Garner FH, Ellis SRM, Lacey JA (1954) Trans Instn Chem Engrs 32:244Google Scholar
  34. 34.
    Boulton-Stone JM, Blake JR (1993) J Fluid Mech 254:237CrossRefGoogle Scholar
  35. 35.
    Briones MA, Brodkey RS, Chalmers JJ (1994) Chem Eng Sci 14:2301CrossRefGoogle Scholar
  36. 36.
    Briones MA, Chalmers RS (1994) Biotech Bioeng 44:1089CrossRefGoogle Scholar
  37. 37.
    Naue G, Liepe F, Maschek HJ, Reher, EO, Schenk R (1988) Technische Strömungslehre I, VEB Deutscher Verlag für Grundstoffindustrie, LeipzigGoogle Scholar
  38. 38.
    Reiter M (1983). Untersuchungen zur Flokkulation im Zylinderrühreaktor und im durchströmten Rohr. Dissertation, Universität BerlinGoogle Scholar
  39. 39.
    Taylor G (1936) Proc R Soc London A157:546CrossRefGoogle Scholar
  40. 40.
    Baldyga J, Bourne JR, Zimmermann B (1994) Chem Eng Sci 49:1937CrossRefGoogle Scholar
  41. 41.
    Baldyga J, Bourne JR, Gholap RV (1995) Chem Eng Sci 50:1877CrossRefGoogle Scholar
  42. 42.
    Tralles S (1998) Entwicklung eines Testsystems zur Bestimmung der Scherbeanspruchung in Bioreaktoren. Master Thesis, Universität PaderbornGoogle Scholar
  43. 43.
    Hoffmann J, Tralles S, Hempel DC (1992) Chem Ing Tech 64:953CrossRefGoogle Scholar
  44. 44.
    Biedermann A, Henzler HJ (1994) Chem Ing Tech 66:209CrossRefGoogle Scholar
  45. 45.
    Biedermann A (1994) Scherbeanspruchung in Bioreaktoren. Dissertation Universität KölnGoogle Scholar
  46. 46.
    Bücher K (1993) Scherbeanspruchung in Bioreaktoren. Master Thesis Universität PaderbornGoogle Scholar
  47. 47.
    Jüsten P (1993) Scherbeanspruchung in Bioreaktoren. Master Thesis Technische Hochschule AachenGoogle Scholar
  48. 48.
    Ke\ler M (1994) Scherbeanspruchung in Bioreaktoren. Master Thesis Universität KölnGoogle Scholar
  49. 49.
    Schumacher C (1994) Partikelbeanspruchung in Reaktoren. Master Thesis Technische Hochschule AachenGoogle Scholar
  50. 50.
    Hoffmann J, Büscher K, Hempel DC (1995) Chem Ing Tech 67:210CrossRefGoogle Scholar
  51. 51.
    Hoffmann J (1994) Scherkräfte in Bioreaktoren. Dissertation Universität PaderbornGoogle Scholar
  52. 52.
    Bücher K (1997) Bestimmung von mechanischen Beanspruchungen in Zweiphasensystemen. Dissertation Universität PaderbornGoogle Scholar
  53. 53.
    Ayazai Shamlou P, Makagiansar HY, Ison AP, Lilly MD (1994) Chem Eng Sci 16:2631Google Scholar
  54. 54.
    Paul GC, Thomas CR (1998) Advances in Biochem Eng Biotechnology 60:1CrossRefGoogle Scholar
  55. 55.
    Pons MN, Vivier H (1998) Advances in Biochem Eng Biotechnology 60:61Google Scholar
  56. 56.
    Schügerl K, Gerlach SR, Siedenburg D (1998) Advances in Biochem Eng Biotechnology 60:195Google Scholar
  57. 57.
    van Hamersfeld EH, van der Lans RGJM, Luyben KCAM (1997) Biotech Bioeng 56:190CrossRefGoogle Scholar
  58. 58.
    Moreira JL, Cruz PE, Santana CS, Aunins JG (1995) Chem Eng Sci 50:2747CrossRefGoogle Scholar
  59. 59.
    Shamlou PA, Stravrinides N, Titchner-Höcker N, Hoore M (1994) Chem Eng Sci 49:2647CrossRefGoogle Scholar
  60. 60.
    Jüsten P (1997) Dependence of Penicillium Chrysogenum growth, morphology, vacuolation and productivity on impeller type and agitation intensity. PHD Thesis University of BirminghamGoogle Scholar
  61. 61.
    Henzler HJ, Kauling J (1985) Scale up of mass transfer in highly viscous liquids. Preprints of 5th European Conference on Mixing, WürzburgGoogle Scholar
  62. 62.
    Dechema Study for research and development: “Standardization and equipment recommendations for bioreactors and peripheral devices” (1990)Google Scholar
  63. 64.
    Zhou G, Kresta SM (1996) Chem Eng Sci 44:2207Google Scholar
  64. 65.
    Schlichting H (1968) Boundary-Layer Theory. McGraw-Hill New YorkGoogle Scholar
  65. 66.
    Flagmeyer A, Konstantinov K, Henzler HJ submitted in Biotechnol and BioengGoogle Scholar
  66. 67.
    Meier SJ, Hatton TA, Wang DIC (1999) Biotechnol and Bioeng 62:468CrossRefGoogle Scholar
  67. 68.
    Hülscher M (1990) Fortschritts Berichte VDI Z, Series 3, no. 339, VDI, DüsseldorfGoogle Scholar
  68. 69.
    Blenke H (1979) Adv Biochem Eng 13:121Google Scholar
  69. 70.
    Merchuk JC, Berzin I (1995) Chem Eng Sci 50:2225CrossRefGoogle Scholar
  70. 71.
    Ueda K, Takebe H, Takahashi J, Nomoto M (1971) Ferment Technol 49:981Google Scholar
  71. 72.
    Büchs J, Zoels B (1999) Evaluation of the Maximum Specific Power Consumption in Shaking Bioreactors, Proceedings of 3th International Symposium on Mixing in Industrial Processes (ISMIP-3) 19–22 Sept 1999 JapanGoogle Scholar
  72. 73.
    Yoshida F, Yamada T (1971) Fermen Technol 49:235Google Scholar
  73. 74.
    Smith JJ, Lilly, MD, Fox RI (1990) Biotech Bioeng 35:1011CrossRefGoogle Scholar
  74. 75.
    Smith GC, Greenfield FP, Randerson DH (1987) Biotechnol Techniques 1:39CrossRefGoogle Scholar
  75. 76.
    Abu-Reesh I, Kargi F (1989) Journal of Biotechnology 9:167CrossRefGoogle Scholar
  76. 77.
    Cherry RS, Known KJ (1990) Biotechnol and Bioeng 36:563CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • Hans-Jürgen Henzler
    • 1
  1. 1.Process Development/Bioprocess EngineeringBayer AGWuppertalGermany

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