DNA implementation of a Royal Road fitness evaluation

  • Elizabeth Goode
  • David Harlan Wood
  • Junghuei Chen
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 2054)


A model for DNA implementation of Royal Road evolutionary computations is presented. An encoding for a Royal Road problem is presented. Experimental results utilizing 2-d denaturing gradient gel electrophoresis (2-d DGGE) and polyacrylamide gel electrophoresis (PAGE) for separation by fitness in this sample Royal Road problem are shown. Suggestions for possible use of the MutS and MutY proteins as tools for separation by fitness are given. Plans for future experiments and implementation are discussed.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • Elizabeth Goode
    • 1
  • David Harlan Wood
    • 1
  • Junghuei Chen
    • 1
  1. 1.University of DelawareNewarkUSA

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