Applying Memetic Algorithms to the Analysis of Microarray Data

  • Carlos Cotta
  • Alexandre Mendes
  • Vinícius Garcia
  • Paulo França
  • Pablo Moscato
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 2611)

Abstract

This work deals with the application of Memetic Algorithms to the Microarray Gene Ordering problem, a NP-hard problem with strong implications in Medicine and Biology. It consists in ordering a set of genes, grouping together the ones with similar behavior. We propose a MA, and evaluate the influence of several features, such as the intensity of local searches and the utilization of multiple populations, in the performance of the MA. We also analyze the impact of different objective functions on the general aspect of the solutions. The instances used for experimentation are extracted from the literature and represent real biological systems.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • Carlos Cotta
    • 1
  • Alexandre Mendes
    • 2
  • Vinícius Garcia
    • 2
  • Paulo França
    • 2
  • Pablo Moscato
    • 3
  1. 1.Dept. Lenguajes y Ciencias de la ComputaciónUniversity of Málaga, ETSI InformáticaMálagaSpain
  2. 2.Faculdade de Engenharia Elétrica e de ComputaçãoUniversidade Estadual de CampinasCampinasBrazil
  3. 3.School of Electrical Engineering and Computer ScienceUniversity of NewcastleCallaghanAustralia

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