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A molecular dissection of the glycoprotein hormone receptors

  • Gilbert Vassart
  • Leonardo Pardo
  • Sabine Costagliola
Part of the Research and Perspectives in Endocrine Interactions book series (RPEI)

Summary

In glycoprotein hormone receptors, a subfamily of rhodopsin-like G protein-coupled receptors, the recognition and activation steps are carried out by separate domains of the proteins. Specificity of recognition of the hormones [thyrotropin (TSH), lutropin (LH), human chorionic gonadotropin (hCG), follitropin (FSH)] involves leucine-rich repeats (LRR) present in an aminoterminal ectodomain and can be associated with a limited number of residues at key positions of the LRRs. The mechanism by which binding of the hormones results in activation is proposed to involve switching of the ectodomain from a tethered inverse agonist to a full agonist of the serpentine, rhodopsin-like portion of the receptor. Unexpectedly, the picture is complicated by the observation that promiscuous activation of one of the receptors (FSHr) by hCG or TSH can result from activating mutations affecting the serpentine portion of the receptors.

Keywords

Molecular Electrostatic Potential Luteinizing Hormone Receptor Thyrotropin Receptor Thyroid Adenoma Molecular Dissection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Gilbert Vassart
    • 1
    • 2
  • Leonardo Pardo
    • 3
  • Sabine Costagliola
    • 1
  1. 1.IRIBHMUniversité Libre de BruxellesBrusselsBelgium
  2. 2.Service de Génétique MédicaleHôpital ErasmeBrusselsBelgium
  3. 3.Laboratori de Medicina Computacional, Unitat de Bioestadística, Facultat de MedicinaUniversitat Autònoma de BarcelonaBellaterraSpain

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