The Pioneer Settlement of Modern Humans in Asia

  • Mait Metspalu
  • Toomas Kivisild
  • Hans-Jürgen Bandelt
  • Martin Richards
  • Richard Villems
Part of the Nucleic Acids and Molecular Biology book series (NUCLEIC, volume 18)

7 Conclusion

The SCR of the pioneer phase of the peopling of the vast territories of Asia has gained increasingly strong experimental support, thanks to recently acquired deeper phylogenetic and phylogeographic knowledge about the spread of mtDNA (and Y-chromosomal) variation in this continent. Much, if not all, of the early settlement process can be seen as a ‘fast train to Southeast Asia and Australia along the SCR’—indeed, so fast that the founder haplotypes at the base of haplogroups M, N, and R reached all major destinations alongside the route, as far down as Australia. It appears that Central Asia and southern Siberia were not involved in the initial peopling of the continent. It is also evident that the initial fast train phase was followed by a long-lasting freezing of the major geographic pools of maternal lineages in the south and further gene flows northwards from Southeast Asia and subsequently back westwards along the Steppe Belt extending from Manchuria to Europe. At present, western Siberia, the Urals, and Central Asia form a huge continuous admixture zone encompassing East and West Eurasian maternal lineages—a process that has so far had only a minimal influence on the essentially distinct autochthonous patterns of mtDNA variation in most of South Asia, East Asia, Southeast Asia, and Australasia.


Last Glacial Maximum Modern Human Steppe Belt Anatomically Modern Human Pioneer Settlement 
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  1. Adams JM, Faure H (1997) Global land environments during the last interglacial. Oak Ridge National Laboratory, Oak RidgeGoogle Scholar
  2. Adams JM, Maslin M, Thomas E (1999) Sudden climate transitions during the Quaternary. Prog Phys Geogr 23:1–36CrossRefGoogle Scholar
  3. Ballinger SW, Schurr TG, Torroni A, Gan YY, Hodge JA, Hassan K, Chen KH, Wallace DC (1992) Southeast Asian mitochondrial DNA analysis reveals genetic continuity of ancient mongoloid migrations. Genetics 130:139–152PubMedGoogle Scholar
  4. Barker G, Barton H, Beavitt P, Bird M, Daly P, Doherty C, Gilbertson D, Hunt C, Krigbaum J, Lewis H, Manser J, McLaren S, Paz V, Piper P, Pyatt B, Rabett R, Reynolds T, Rose J, Rushworth G, Stephens M (2002) Prehistoric foragers and farmers in Southeast Asia: renewed investigations at Niah Cave, Sarawak. Proc Prehist Soc 68:147–164Google Scholar
  5. Bar-Yosef O (2001) Dating the transition from the Middle to Upper Palaeolithic. Paper presented at XXIe Rencontres internationales d’archeologie et d’historie d’Antibes, AntibesGoogle Scholar
  6. Bermisheva MA, Kutuev IA, Korshunova TY, Dubova NA, Villems R, Khusnutdinova EK (2004) Phylogeographic analysis of mitochondrial DNA in the Nogays: A strong mixture of maternal lineages from eastern and western Eurasia. Mol Biol (Mosk) 38:516–523CrossRefGoogle Scholar
  7. Bowler J, Johnston H, Olley J, Prescott J, Roberts R, Shawcross W, Spooner N (2003) New ages for human occupation and climatic change at Lake Mungo, Australia. Nature 421:837–840PubMedCrossRefGoogle Scholar
  8. Chakrabarti DK (1999) India. An archaeological history. Palaeolithic beginnings to early historic foundations. Oxford University Press, New DelhiGoogle Scholar
  9. Chappell J (2002) Sea level changes forced ice breakouts in the Last Glacial cycle: new results from coral terraces. Quat Sci Rev 21:1229–1240CrossRefGoogle Scholar
  10. Chen TM, Zhang YY (1991) Palaeolithic chronology and possible co-existence of H. erectus and H. sapiens in China. World Archeol 23:147–154CrossRefGoogle Scholar
  11. Comas D, Plaza S, Wells RS, Yuldaseva N, Lao O, Calafell F, Bertranpetit J (2004) Admixture, migrations, and dispersals in Central Asia: evidence from maternal DNA lineages. Eur J Hum Genet 12:495–504PubMedCrossRefGoogle Scholar
  12. Cruciani F, La Fratta R, Santolamazza P, Sellitto D, Pascone R, Moral P, Watson E, Guida V, Colomb EB, Zaharova B, Lavinha J, Vona G, Aman R, Calì F, Akar N, Richards M, Torroni A, Novelletto A, Scozzari R (2004) Phylogeographic analysis of haplogroup E3b (E-M215) Y chromosomes reveals multiple migratory events within and out of Africa. Am J Hum Genet 74:1014–1022PubMedCrossRefGoogle Scholar
  13. Derenko MV, Grzybowski T, Malyarchuk BA, Dambueva IK, Denisova GA, Czarny J, Dorzhu CM, Kakpakov VT, Miścicka-Śliwka D, Woźniak M, Zakharov IA (2003) Diversity of mitochondrial DNA lineages in south Siberia. Ann Hum Genet 67:391–411PubMedCrossRefGoogle Scholar
  14. Dolukhanov PM, Shukurov AM, Tarasov PE, Zaitseva GI (2002) Colonization of northern Eurasia by modern humans: radiocarbon chronology and environment. J Arch Sci 29:593–606CrossRefGoogle Scholar
  15. Etler DA (1996) The fossil evidence for human evolution in Asia. Annu Rev Anthropol 25:275–301CrossRefGoogle Scholar
  16. Foley R (1998) The context of human genetic evolution. Genome Res 8:339–347PubMedGoogle Scholar
  17. Forster P, Harding R, Torroni A, Bandelt H-J (1996) Origin and evolution of Native American mtDNA variation: a reappraisal. Am J Hum Genet 59:935–945PubMedGoogle Scholar
  18. Forster P, Torroni A, Renfrew C, Röhl A (2001) Phylogenetic star contraction applied to Asian and Papuan mtDNA evolution. Mol Biol Evol 18:1864–1881PubMedGoogle Scholar
  19. Gilead I (1991) The Upper Palaeolithic period in the Levant. J World Prehist 5:105–154CrossRefGoogle Scholar
  20. Ingman M, Gyllensten U (2003) Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines. Genome Res 13:1600–1606PubMedCrossRefGoogle Scholar
  21. Jobling MA, Tyler-Smith C (2003) The human Y chromosome: an evolutionary marker comes of age. Nat Rev Genet 4:598–612PubMedCrossRefGoogle Scholar
  22. Joshi RV (1996) South Asia in the period of Homo sapiens neanderthalensis and contemporaries (Middle Palaeolithic), vol I. UNESCOGoogle Scholar
  23. Kennedy KA, Deraniyagala SU, Roertgen WJ, Chiment J, Disotell T (1987) Upper Pleistocene fossil hominids from Sri Lanka. Am J Phys Anthropol 72:441–461PubMedCrossRefGoogle Scholar
  24. Kennedy KAR, Deraniyagala SU (1989) Fossil remains of 28 000-year-old hominids from Sri Lanka. Curr Anthropol 30:394–399CrossRefGoogle Scholar
  25. Kivisild T, Bamshad MJ, Kaldma K, Metspalu M, Metspalu E, Reidla M, Laos S, Parik J, Watkins WS, Dixon ME, Papiha SS, Mastana SS, Mir MR, Ferak V, Villems R (1999a) Deep common ancestry of Indian and western-Eurasian mitochondrial DNA lineages. Curr Biol 9:1331–1334PubMedCrossRefGoogle Scholar
  26. Kivisild T, Kaldma K, Metspalu M, Parik J, Papiha SS, Villems R (1999b) The place of the Indian mitochondrial DNA variants in the global network of maternal lineages and the peopling of the Old World. In: Papiha SS, Deka R, Chakraborty R (eds) Genomic diversity. Kluwer/Plenum, Dordrecht, pp 135–152Google Scholar
  27. Kivisild T, Papiha SS, Rootsi S, Parik J, Kaldma K, Reidla M, Laos S, Metspalu M, Pielberg G, Adojaan M, Metspalu E, Mastana SS, Wang Y, Gölge M, Demirtas H, Schnekenberg E, Stefano GF, Geberhiwot T, Claustres M, Villems R (2000) An Indian ancestry: a key for understanding human diversity in Europe and beyond. In: Renfrew C, Boyle K (eds) Archaeogenetics: DNA and the population prehistory of Europe. McDonald Institute for Archaeological Research University of Cambridge, Cambridge, pp 267–279Google Scholar
  28. Kivisild T, Tolk H-V, Parik J, Wang Y, Papiha SS, Bandelt H-J, Villems R (2002) The emerging limbs and twigs of the East Asian mtDNA tree. Mol Biol Evol 19:1737–1751 (erratum 20:162)PubMedGoogle Scholar
  29. Kivisild T, Rootsi S, Metspalu M, Mastana S, Kaldma K, Parik J, Metspalu E, Adojaan M, Tolk H-V, Stepanov V, Gölge M, Usanga E, Papiha SS, Cinnioglu C, King R, Cavalli-Sforza L, Underhill PA, Villems R (2003) The genetic heritage of the earliest settlers persists both in Indian tribal and caste populations. Am J Hum Genet 72:313–332PubMedCrossRefGoogle Scholar
  30. Kivisild T, Reidla M, Metspalu E, Rosa A, Brehm A, Pennarun E, Parik J, Geberhiwot T, Usanga E, Villems R (2004) Ethiopian mitochondrial DNA heritage: tracking gene flows across and around the Strait of Tears. Am J Hum Genet 75:752–770PubMedCrossRefGoogle Scholar
  31. Klein R (1999) The human career. University of Chicago Press, ChicagoGoogle Scholar
  32. Kong Q-P, Yao Y-G, Sun C, Bandelt H-J, Zhu C-L, Zhang Y-P (2003) Phylogeny of East Asian mitochondrial DNA lineages inferred from complete sequences. Am J Hum Genet 73:671–676PubMedCrossRefGoogle Scholar
  33. Kumar V, Reddy M (2003) Status of Austro-Asiatic groups in the peopling of India: An exploratory study based on the available prehistoric, linguistic and biological evidences. J Biosci 28:507–522PubMedGoogle Scholar
  34. Kuzmin YV, Keates SG (2004) Comment on “Colonization of northern Eurasia by modern humans: radiocarbon chronology and environment” by P.M. Dolukhanov, A.M. Shukurov, P.E. Tarasov and G.I. Zaitseva. Journal of Archaeological Science 29, 593–606 (2002). J Archaeol Sci 31:141–143Google Scholar
  35. Lahr M, Foley R (1994) Multiple dispersals and modern human origins. Evol Anthropol 3:48–60CrossRefGoogle Scholar
  36. Luis JR, Rowold DJ, Regueiro M, Caeiro B, Cinnioglu C, Roseman C, Underhill PA, Cavalli-Sforza LL, Herrera RJ (2004) The Levant versus the Horn of Africa: evidence for bidirectional corridors of human migrations. Am J Hum Genet 74:532–544 (erratum 74:788)PubMedCrossRefGoogle Scholar
  37. Maca-Meyer N, González AM, Larruga JM, Flores C, Cabrera VM (2001) Major genomic mitochondrial lineages delineate early human expansions. BMC Genet 2:13PubMedCrossRefGoogle Scholar
  38. Macaulay V, Hill C, Achilli A, Rengo C, Clarke D, Meehan W, Blackburn J, Semino O, Scozzari R, Cruciani F, Taha A, Shaari NK, Raja JM, Ismail P, Zainuddin Z, Goodwin W, Bulbeck D, Bandelt H-J, Oppenheimer S, Torroni A, Richards M (2005) Single, rapid coastal settlement of Asia revealed by analysis of complete mitochondrial genomes. Science 308:1034–1036PubMedCrossRefGoogle Scholar
  39. Maruyama S, Minaguchi K, Saitou N (2003) Sequence polymorphisms of the mitochondrial DNA control region and phylogenetic analysis of mtDNA lineages in the Japanese population. Int J Legal Med 117:218–225PubMedCrossRefGoogle Scholar
  40. Merriwether DA, Hodgson JA, Friedlaender FR, Allaby R, Cerchio S, Koki G, Friedlaender JS (2005) Ancient mitochondrial M haplogroups identified in the Southwest Pacific. Proc Natl Acad Sci USA 102:13034–13039PubMedCrossRefGoogle Scholar
  41. Metspalu M, Kivisild T, Metspalu E, Parik J, Hudjashov G, Kaldma K, Serk P, Karmin M, Behar DM, Gilbert MTP, Endicott P, Mastana S, Papiha SS, Skorecki K, Torroni A, Villems R (2004) Most of the extant mtDNA boundaries in South and Southwest Asia were likely shaped during the initial settlement of Eurasia by anatomically modern humans. BMC Genet 5:26 (erratum 6:41)PubMedCrossRefGoogle Scholar
  42. Mishmar D, Ruiz-Pesini E, Golik P, Macaulay V, Clark AG, Hosseini S, Brandon M, Easley K, Chen E, Brown MD, Sukernik RI, Olckers A, Wallace DC (2003) Natural selection shaped regional mtDNA variation in humans. Proc Natl Acad Sci USA 100:171–176PubMedCrossRefGoogle Scholar
  43. Olszewski DI, Dibble HL (1994) The Zagros Aurignacian. Curr Anthropol 35:68–75CrossRefGoogle Scholar
  44. Oppenheimer S (2003) Out of Eden: the peopling of the world. Constable, LondonGoogle Scholar
  45. Pakendorf B, Stoneking M (2005) Mitochondrial DNA and human evolution. Annu Rev Genomics Hum Genet 6:165–183PubMedCrossRefGoogle Scholar
  46. Palanichamy M, Sun C, Agrawal S, Bandelt H-J, Kong Q-P, Khan F, Wang C-Y, Chaudhuri T, Palla V, Zhang Y-P (2004) Phylogeny of mtDNA macrohaplogroup N in India based on complete sequencing: implications for the peopling of South Asia. Am J Hum Genet 75:966–978PubMedCrossRefGoogle Scholar
  47. Quintana-Murci L, Semino O, Bandelt H-J, Passarino G, McElreavey K, Santachiara-Benerecetti AS (1999) Genetic evidence of an early exit of Homo sapiens sapiens from Africa through eastern Africa. Nat Genet 23:437–441PubMedCrossRefGoogle Scholar
  48. Quintana-Murci L, Chaix R, Wells S, Behar D, Sayar H, Scozzari R, Rengo C, Al-Zahery N, Semino O, Santachiara-Benerecetti A, Coppa A, Ayub Q, Mohyuddin A, Tyler-Smith C, Mehdi Q, Torroni A, McElreavey K (2004) Where West meets East: the complex mtDNA landscape of the Southwest and Central Asian corridor. Am J Hum Genet 74:827–845PubMedCrossRefGoogle Scholar
  49. Ray N, Adams JM (2001) A GIS-based vegetation map of the world at the Last Glacial Maximum (25 000–15 000 BP). Internet Archaeol 11Google Scholar
  50. Richards M, Macaulay V, Hickey E, Vega E, Sykes B, Guida V, Rengo C et al. (2000) Tracing European founder lineages in the Near Eastern mtDNA pool. Am J Hum Genet 67:1251–1276PubMedGoogle Scholar
  51. Roberts RG, Jones R, Smith MA (1990) Thermoluminescence dating of a 50 000-year-old human occupation site in northern Australia. Nature 345: 153–156CrossRefGoogle Scholar
  52. Roberts RG, Jones R, Spooner NA, Head MJ, Murray AS, Smith MA (1994) The human colonisation of Australia: optical dates of 53 000 and 60 000 years bracket human arrival at Deaf Adder Gorge, Northern Territory. Quat Sci Rev 13:575–583CrossRefGoogle Scholar
  53. Sauer C (1962) Seashore—primitive home of man? Proc Am Philos Soc 106:41–47Google Scholar
  54. Scott GR, Turner CGI (1997) The anthropology of modern human teeth. Dental morphology and its variation in recent human populations. Cambridge University Press, CambridgeGoogle Scholar
  55. Semino O, Magri C, Benuzzi G, Lin AA, Al-Zahery N, Battaglia V, Maccioni L, Triantaphyllidis C, Shen P, Oefner PJ, Zhivotovsky LA, King R, Torroni A, Cavalli-Sforza LL, Underhill PA, Santachiara-Benerecetti AS (2004) Origin, diffusion, and differentiation of Y-chromosome haplogroups E and J: inferences on the neolithization of Europe and later migratory events in the Mediterranean area. Am J Hum Genet 74:1023–1034PubMedCrossRefGoogle Scholar
  56. Shen G, Wang W, Wang Q, Zhao J, Collerson K, Zhou C, Tobias PV (2002) U-Series dating of Liujiang hominid site in Guangxi, southern China. J Hum Evol 43:817–829PubMedCrossRefGoogle Scholar
  57. Stoneking M, Jorde LB, Bhatia K, Wilson AC (1990) Geographic variation in human mitochondrial DNA from Papua New Guinea. Genetics 124:717–733PubMedGoogle Scholar
  58. Stringer C (2000) Coasting out of Africa. Nature 405:24–25, 27PubMedCrossRefGoogle Scholar
  59. Su B, Xiao J, Underhill P, Deka R, Zhang W, Akey J, Huang W, Shen D, Lu D, Luo J, Chu J, Tan J, Shen P, Davis R, Cavalli-Sforza L, Chakraborty R, Xiong M, Du R, Oefner P, Chen Z, Jin L (1999) Y-Chromosome evidence for a northward migration of modern humans into Eastern Asia during the last ice age. Am J Hum Genet 65:1718–1724PubMedCrossRefGoogle Scholar
  60. Sun C, Kong Q-P, Palanichamy Mg, Agrawal S, Bandelt H-J, Yao Y-G, Khan F, Zhu C-L, Chaudhuri TK, Zhang Y-P, (2006) The dazzling array of basal branches in the mtDNA macrohaplogroup M from India as inferred from complete genomes. Mol Biol Evol 23:683–690PubMedCrossRefGoogle Scholar
  61. Sykes B, Leiboff A, Low-Beer J, Tetzner S, Richards M (1995) The origins of the Polynesians: an interpretation from mitochondrial lineage analysis. Am J Hum Genet 57:1463–1475PubMedGoogle Scholar
  62. Tanaka M, Cabrera VM, González AM, Larruga JM, Takeyasu T, Fuku N, Guo L-J, et al. (2004) Mitochondrial genome variation in eastern Asia and the peopling of Japan. Genome Res 14:1832–1850PubMedCrossRefGoogle Scholar
  63. Thorne A, Grun R, Mortimer G, Spooner NA, Simpson JJ, McCulloch M, Taylor L, Curnoe D (1999) Australia’s oldest human remains: age of the Lake Mungo 3 skeleton. J Hum Evol 36:591–612PubMedCrossRefGoogle Scholar
  64. Torroni A, Schurr TG, Cabell MF, Brown MD, Neel JV, Larsen M, Smith DG, Vullo CM, Wallace DC (1993a) Asian affinities and continental radiation of the four founding Native American mtDNAs. Am J Hum Genet 53:563–590PubMedGoogle Scholar
  65. Torroni A, Sukernik RI, Schurr TG, Starikorskaya YB, Cabell MF, Crawford MH, Comuzzie AG, Wallace DC (1993b) mtDNA variation of aboriginal Siberians reveals distinct genetic affinities with Native Americans. Am J Hum Genet 53:591–608PubMedGoogle Scholar
  66. Torroni A, Neel JV, Barrantes R, Schurr TG, Wallace DC (1994) Mitochondrial DNA “clock” for the Amerinds and its implications for timing their entry into North America. Proc Natl Acad Sci USA 91:1158–1162PubMedCrossRefGoogle Scholar
  67. Turney CSM, Bird MI, Fifield LK, Roberts RG, Smith M, Dortch CE, Grun R, Lawson E, Ayliffe LK, Miller GH (2001) Early human occupation at Devil’s Lair, southwestern Australia 50 000 years ago. Quat Res 55:3–13CrossRefGoogle Scholar
  68. Underhill PA, Passarino G, Lin AA, Shen P, Mirazon Lahr M, Foley R, Oefner PJ, Cavalli-Sforza LL (2001) The phylogeography of Y chromosome binary haplotypes and the origins of modern human populations. Ann Hum Genet 65:43–62PubMedCrossRefGoogle Scholar
  69. van Andel T, Davies W, Weninger B (2003) The human presence in Europe during the last glacial period I: human migrations and the changing climate. In: van Andel T, Davies W (eds) Neanderthals and modern humans in the European landscape during the last glaciation. McDonald Institute for Archaeological Research, Cambridge, pp 31–56Google Scholar
  70. Vasil’ev SA, Kuzmin YV, Orlova LA, Dementiev VN (2002) Radiocarbon-based chronology of the Palaeolithic in Siberia and its relevance to the peopling of the New World. Radiocarbon 44:503–530Google Scholar
  71. Wells RS, Yuldasheva N, Ruzibakiev R, Underhill PA, Evseeva I, Blue-Smith J, Jin L, et al. (2001) The Eurasian heartland: a continental perspective on Y-chromosome diversity. Proc Natl Acad Sci USA 98:10244–10249PubMedCrossRefGoogle Scholar
  72. Yao Y-G, Kong Q-P, Bandelt H-J, Kivisild T, Zhang Y-P (2002) Phylogeographic differentiation of mitochondrial DNA in Han Chinese. Am J Hum Genet 70:635–651PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Mait Metspalu
    • 1
  • Toomas Kivisild
    • 1
  • Hans-Jürgen Bandelt
    • 1
  • Martin Richards
    • 1
  • Richard Villems
    • 1
  1. 1.Institute of Molecular and Cell BiologyTartu University and Estonian BiocentreTartuEstonia

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