A Model for the Dispersal of Modern Humans out of Africa

  • Martin Richards
  • Hans-Jürgen Bandelt
  • Toomas Kivisild
  • Stephen Oppenheimer
Part of the Nucleic Acids and Molecular Biology book series (NUCLEIC, volume 18)


Indian Subcontinent Modern Human Much Recent Common Ancestor Southern Route Modern Human Origin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Acharyya SK, Basu PK (1993) Toba ash on the Indian subcontinent and its implications for correlation of late Pleistocene alluvium. Quat Res 40:10–19Google Scholar
  2. Achilli A, Rengo C, Magri C, Battaglia V, Olivieri A, Scozzari R, Cruciani F, Zeviani M, Briem E, Carelli V, Moral P, Dugoujon J-M, Roostalu U, Loogväli E-L, Kivisild T, Bandelt H-J, Richards M, Villems R, Santachiara-Benerecetti AS, Semino O, Torroni A (2004) The molecular dissection of mtDNA haplogroup H confirms that the Franco-Cantabrian glacial refuge was a major source for the European gene pool. Am J Hum Genet 75:910–918PubMedGoogle Scholar
  3. Achilli A, Rengo C, Battaglia V, Pala M, Olivieri A, Fornarino S, Magri C, Scozzari R, Babudri N, Santachiara-Benerecetti AS, Bandelt H-J, Semino O, Torroni A (2005) Saami and Berbers—an unexpected mitochondrial DNA link. Am J Hum Genet 76:883–886PubMedGoogle Scholar
  4. Alonso S, Armour JAL (2001) A highly variable segment of human subterminal 16p reveals a history of population growth for modern humans outside Africa. Proc Natl Acad Sci USA 98:864–869PubMedGoogle Scholar
  5. Ambrose SH (1998) Late Pleistocene human population bottlenecks, volcanic winter, and differentiation of modern humans. J Hum Evol 34:623–651PubMedGoogle Scholar
  6. Ambrose SH (2003) Did the super-eruption of Toba cause a human bottleneck? Reply to Gathorne-Hardy and Harcourt-Smith. J Hum Evol 45:231–237PubMedGoogle Scholar
  7. Anderson S, Bankier AT, Barrell BG, de Bruijn MHL, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, Schreier PH, Smith AJH, Staden R, Young IG (1981) Sequence and organization of the human mitochondrial genome. Nature 290:457–465PubMedGoogle Scholar
  8. Arredi B, Poloni ES, Paracchini S, Zerjal T, Fathallah DM, Makrelouf M, Pascali VL, Novelletto A, Tyler-Smith C (2004) A predominantly Neolithic origin for Y-chromosomal DNA variation in North Africa. Am J Hum Genet 75:338–345PubMedGoogle Scholar
  9. Bamshad M, Kivisild T, Watkins WS, Dixon ME, Ricker CE, Rao BB, Naidu JM, Prasad BVR, Reddy PG, Rasanayagam A, Papiha SS, Villems R, Redd AJ, Hammer MF, Nguyen SV, Carroll ML, Batzer MA, Jorde LB (2001) Genetic evidence on the origins of Indian caste populations. Genome Res 11:994–1004PubMedGoogle Scholar
  10. Bandelt H-J (2005) Exploring reticulate patterns in DNA sequence data. In: Bakker FT, Chatrou LW, Gravendeel B, Pelser PB (eds) Plant species-level systematics: new perspectives on pattern & process. Regnum vegetabile 142. Koeltz, Königstein, pp 245–270Google Scholar
  11. Barbujani G, Bertorelle G, Chikhi L (1998) Evidence for Paleolithic and Neolithic gene flow in Europe. Am J Hum Genet 62:488–491PubMedGoogle Scholar
  12. Barker G, Barton H, Beavitt P, Bird M, Daly P, Doherty C, Gilbertson D, Hunt C, Krigbaum J, Lewis H, Manser J, McLaren S, Paz V, Piper P, Pyatt B, Rabett R, Reynolds T, Rose J, Rushworth G, Stephens M (2002) Prehistoric foragers and farmers in southeast Asia: renewed investigations at Niah Cave, Sarawak. Proc Prehist Soc 68:147–164Google Scholar
  13. Bar-Yosef O (1998) On the nature of transitions: the Middle to Upper Palaeolithic and the Neolithic Revolution. Camb Arch J 8:141–163Google Scholar
  14. Blanc H, Chen KH, D’Amore MA, Wallace DC (1983) Amino acid change associated with the major polymorphic HincII site of Oriental and Caucasian mitochondrial DNAs. Am J Hum Genet 35:157–176Google Scholar
  15. Bosch E, Calafell F, Comas D, Oefner PJ, Underhill PA, Bertranpetit J (2001) High-resolution analysis of human Y-chromosome variation shows a sharp discontinuity and limited gene flow between northwestern African and the Iberian peninsula. Am J Hum Genet 68:1019–1029PubMedGoogle Scholar
  16. Brega A, Gardella R, Semino O, Morpurgo G, Astaldi Ricotti GB, Wallace DC, Santachiara-Benerecetti AS (1986) Genetic studies on the Tharu population of Nepal: restriction endonuclease polymorphisms of mitochondrial DNA. Am J Hum Genet 39:502–512PubMedGoogle Scholar
  17. Brinkmann B, Klintschar M, Heuhuber F, Hühne J, Rolf B (1998) Mutation rate in human microsatellites: influence of the structure and length of the tandem repeat. Am J Hum Genet 62:1408–1415PubMedGoogle Scholar
  18. Brown WM (1980) Polymorphism in mitochondrial DNA of human as revealed by restriction endonuclease analysis. Proc Natl Acad Sci USA 77:3605–3609PubMedGoogle Scholar
  19. Cann RL (1984) Mitochondrial DNA variation in Australian aborigines: the spread of modern populations. Acta Anthropogenet 8:125–135PubMedGoogle Scholar
  20. Cann RL, Stoneking M, Wilson AC (1987) Mitochondrial DNA and human evolution. Nature 325:31–36PubMedGoogle Scholar
  21. Capelli C, Wilson JF, Richards M, Stumpf MPH, Gratrix F, Oppenheimer S, Underhill P, Pascali VL, Ko T-M, Goldstein DB (2001) A predominantly indigenous paternal heritage for the Austronesian-speaking peoples of insular Southeast Asia and Oceania. Am J Hum Genet 68:432–443PubMedGoogle Scholar
  22. Cavalli-Sforza LL, Menozzi P, Piazza A (1994) The history and geography of human genes. Princeton University Press, PrincetonGoogle Scholar
  23. Chappell J (2002) Sea level changes forced ice breakouts in the Last Glacial cycle: new results from coral terraces. Quat Sci Rev 21:1229–1240Google Scholar
  24. Clark JD (1970) The prehistory of Africa. Praeger, New YorkGoogle Scholar
  25. Comas D, Calafell F, Mateu E, Pérez-Lezaun A, Bosch E, Martínez-Arias R, Clarimon J, Facchini F, Fiori G, Luiselli D, Pettener D, Bertranpetit J (1998) Trading genes along the Silk Road: mtDNA sequences and the origin of central Asian populations. Am J Hum Genet 63:1824–1838PubMedGoogle Scholar
  26. Comas D, Plaza S, Wells RS, Yuldaseva N, Lao O, Calafell F, Bertranpetit J (2004) Admixture, migrations, and dispersals in Central Asia: evidence from maternal DNA lineages. Eur J Hum Genet 12:495–504PubMedGoogle Scholar
  27. Coon CS (1962) The origin of races. Knopf, New YorkGoogle Scholar
  28. Cordaux R, Stoneking M (2003) South Asia, the Andamanese, and the genetic evidence for an “early” human dispersal out of Africa. Am J Hum Genet 72:1586–1590PubMedGoogle Scholar
  29. Cruciani F, Santolamazza P, Shen PD, Macaulay V, Moral P, Olckers A, Modiano D, Holmes S, Destro-Bisol G, Coia V, Wallace DC, Oefner PJ, Torroni A, Cavalli-Sforza LL, Scozzari R, Underhill PA (2002) A back migration from Asia to sub-Saharan Africa is supported by high-resolution analysis of human Y-chromosome haplotypes. Am J Hum Genet 70:1197–1214PubMedGoogle Scholar
  30. Cruciani F, La Fratta R, Santolamazza P, Sellitto D, Pascone R, Moral P, Watson E, Guida V, Beraud Colomb E, Zaharova B, Lavinha J, Vona G, Aman R, Calì F, Akar N, Richards M, Torroni A, Novelletto A, Scozzari R (2004) Phylogeographic analysis of haplogroup E3b (E-M215) Y chromosomes reveals multiple migratory events within and out of Africa. Am J Hum Genet 74:1014–1022PubMedGoogle Scholar
  31. Dansgaard W, Johnsen SJ, Clausen HB, Dahl-Jensen D, Gundestrup NS, Hammer CU, Hvidberg CS, Steffensen JO, Sveinbjörnsdottir AE, Jouzel J, Bond G (1993) Evidence for general instability of past climate from a 250-kyr ice-core record. Nature 364:218–220Google Scholar
  32. Deacon TW (1997) The symbolic species. Penguin, HarmondsworthGoogle Scholar
  33. Denaro M, Blanc H, Johnson MJ, Chen KH, Wilmsen F, Cavalli-Sforza LL, Wallace DC (1981) Ethnic variation in HpaI endonuclease cleavage patterns of human mitochondrial DNA. Proc Natl Acad Sci USA 78:5768–5772PubMedGoogle Scholar
  34. D’Errico F, Henshilwood C, Nilssen P (2001) An engraved bone fragment from c.70,000 year-old Middle Stone Age levels at Blombos Cave, South Africa: implications for the origin of symbolism and language. Antiquity 75:309–318Google Scholar
  35. Dolukhanov PM, Shukurov AM, Tarasov PE, Zaitseva GI (2002) Colonization of northern Eurasia by modern humans: radiocarbon chronology and environment. J Archaeol Sci 29:593–606Google Scholar
  36. Edwin D, Vishwanathan H, Roy S, Rani MVU, Majumder PP (2002) Mitochondrial DNA diversity among five tribal populations of southern India. Current Sci 83:158–162Google Scholar
  37. Endicott P, Gilbert MT, Stringer C, Lalueza-Fox C, Willerslev E, Hansen AJ, Cooper A (2003a) The genetic origins of the Andaman Islanders. Am J Hum Genet 72:178–184PubMedGoogle Scholar
  38. Endicott P, Macaulay V, Kivisild T, Stringer C, Cooper A (2003b) Reply to Cordaux and Stoneking. Am J Hum Genet 72:1590–1593Google Scholar
  39. Eswaran V (2002) A diffusion wave out of Africa: the mechanism of the modern human revolution? Curr Anthropol 43:749–774Google Scholar
  40. Foley R (1998) The context of human genetic evolution. Genome Res 8:339–347PubMedGoogle Scholar
  41. Foley R, Lahr MM (1997) Mode 3 technologies and the evolution of modern humans. Camb Arch J 7:3–36Google Scholar
  42. Forster P (2004) Ice ages and the mitochondrial DNA chronology of human dispersals: a review. Philos Trans R Soc Lond Ser B 359:255–264Google Scholar
  43. Forster P, Torroni A, Renfrew C, Röhl A (2001) Phylogenetic star contraction applied to Asian and Papuan mtDNA evolution. Mol Biol Evol 18:1864–1881PubMedGoogle Scholar
  44. Gamble C (1993a) Timewalkers: the prehistory of global colonization. Sutton, StroudGoogle Scholar
  45. Gamble C (1999) The Palaeolithic societies of Europe. Cambridge University Press, CambridgeGoogle Scholar
  46. Gamble C, Davies W, Pettitt P, Richards M (2004) Climate change and evolving human diversity in Europe during the last glacial. Philos Trans R Soc Lond Ser B 359:243–254Google Scholar
  47. Gamble CS (1993b) Ancestors and agendas. In: Yoffee N, Sherratt A (eds) Archaeological theory—who sets the agenda? Cambridge University Press, Cambridge, pp 39–52Google Scholar
  48. Garrigan D, Mobasher Z, Sverson T, Wilder JA, Hammer MF (2005) Evidence for archaic Asian ancestry on the human X chromosome. Mol Biol Evol 22:189–192PubMedGoogle Scholar
  49. Gathorne-Hardy F, Harcourt-Smith WEH (2002) The super-eruption of Toba, did it cause a human bottleneck? J Hum Evol 45:227–230Google Scholar
  50. Gilead I (1991) The Upper Palaeolithic period in the Levant. J World Prehist 5:105–154Google Scholar
  51. Grün R, Stringer CB (1991) Electron spin resonance dating and the evolution of modern humans. Archaeometry 33:153–199Google Scholar
  52. Hammer MF, Karafet T, Rasanayagam A, Wood ET, Altheide TK, Jenkins T, Griffiths RC, Templeton AR, Zegura SL (1998) Out of Africa and back again: nested cladistic analysis of human Y chromosome variation. Mol Biol Evol 15:427–441PubMedGoogle Scholar
  53. Harding RM, Fullerton SM, Griffiths RC, Bond J, Cox MJ, Schneider JA, Moulin DS, Clegg JB (1997) Archaic African and Asian lineages in the genetic ancestry of modern humans. Am J Hum Genet 60:772–789PubMedGoogle Scholar
  54. Harpending HC, Sherry ST, Rogers AR, Stoneking M (1993) The genetic structure of ancient human populations. Curr Anthropol 34:483–496Google Scholar
  55. Hawks J, Hunley K, Lee S-H, Wolpoff M (2001) Population bottlenecks and Pleistocene human evolution. Mol Biol Evol 17:2–22Google Scholar
  56. Henshilwood C, d’Errico F, Vanhaeren M, van Niekerk K, Jacobs Z (2004) Middle Stone Age shell beads from South Africa. Science 304:404PubMedGoogle Scholar
  57. Herrnstadt C, Elson JL, Fahy E, Preston G, Turnbull DM, Anderson C, Ghosh SS, Olefsky JM, Beal MF, Davis RE, Howell N (2002) Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences from the major African, Asian, and European haplogroups. Am J Hum Genet 70:1152–1171 (erratum 71:448–449)PubMedGoogle Scholar
  58. Heyer E, Puymirat J, Dieltjes P, Bakker E, de Knijff P (1997) Estimating Y chromosome specific microsatellite mutation frequencies using deep rooting pedigrees. Hum Mol Genet 6:799–803PubMedGoogle Scholar
  59. Hill EW, Jobling MA, Bradley DG (2000) Y-chromosome variation and Irish origins. Nature 404:351–352PubMedGoogle Scholar
  60. Horai S, Gojobori T, Matsunaga E (1984) Mitochondrial DNA polymorphism in Japanese. I. Analysis with restriction enzymes of six base pair recognition. Hum Genet 68:324–332PubMedGoogle Scholar
  61. Horai S, Matsunaga E (1986) Mitochondrial DNA polymorphism in Japanese. II. Analysis with restriction enzymes of four or five base pair recognition. Hum Genet 72:105–117PubMedGoogle Scholar
  62. Huoponen K, Schurr TG, Chen YS, Wallace DC (2001) Mitochondrial DNA variation in an Aboriginal Australian population: evidence for genetic isolation and regional differentiation. Hum Immunol 62:954–969PubMedGoogle Scholar
  63. Ingman M, Gyllensten U (2003) Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines. Genome Res 13:1600–1606PubMedGoogle Scholar
  64. Ingman M, Kaessmann H, Pääbo S, Gyllensten U (2000) Mitochondrial genome variation and the origin of modern humans. Nature 408:708–713PubMedGoogle Scholar
  65. Jin L, Underhill PA, Doctor V, David RW, Shen P, Cavalli-Sforza LL, Oefner P (1999) Distribution of haplotypes from a chromosome 21 region distinguishes multiple prehistoric human migrations. Proc Natl Acad USA 96:3796–3800Google Scholar
  66. Johnson MJ, Wallace DC, Ferris SD, Ratazzi MC, Cavalli-Sforza LL (1983) Radiation of human mitochondria DNA types analyzed by restriction endonuclease cleavage patterns. J Mol Evol 19:255–271PubMedGoogle Scholar
  67. Joshi RV (1994) South Asia in the period of Homo sapiens neanderthalensis and contemporaries (Middle Palaeolithic). In: De Laet SJ (ed) History of humanity. Vol I, UNESCO, London, pp 162–164Google Scholar
  68. Kaessmann H, Heissig F, von Haeseler A, Pääbo S (1999) DNA sequence variation in a non-coding region of low recombination on the human X chromosome. Nat Genet 22:78–81PubMedGoogle Scholar
  69. Kayser M, Sajantila A (2000) Mutations at Y-STR loci: implications for paternity testing and forensic analysis. Forensic Sci Int 118:116–121Google Scholar
  70. Kayser M, Brauer S, Weiss G, Schiefenhövel W, Underhill PA, Stoneking M (2001) Independent histories of human Y chromosomes from Melanesia and Australia. Am J Hum Genet 68:173–190PubMedGoogle Scholar
  71. Kayser M, Brauer S, Weiss G, Schiefenhövel W, Underhill P, Shen PD, Oefner P, Tommaseo-Ponzetta M, Stoneking M (2003) Reduced Y-chromosome, but not mitochondrial DNA, diversity in human populations from West New Guinea. Am J Hum Genet 72:281–302PubMedGoogle Scholar
  72. Ke Y, Su B, Song X, Lu D, Chen L, Li H, Qi C, Marzuki S, Deka R, Underhill P, Xiao C, Shriver M, Lell J, Wallace D, Wells RS, Seielstad M, Oefner P, Zhu D, Jin J, Huang W, Chakraborty R, Chen Z, Jin L (2001) African origin of modern humans in East Asia: a tale of 12,000 Y chromosomes. Science 292:1151–1153PubMedGoogle Scholar
  73. Kingdon J (1993) Self-made man—and his undoing. Simon & Schuster, LondonGoogle Scholar
  74. Kivisild T, Bamshad MJ, Kaldma K, Metspalu M, Metspalu E, Reidla M, Laos S, Parik J, Watkins WS, Dixon ME, Papiha SS, Mastana SS, Mir MR, Ferak V, Villems R (1999a) Deep common ancestry of Indian and western Eurasian mtDNA lineages. Curr Biol 9:1331–1334PubMedGoogle Scholar
  75. Kivisild T, Kaldma K, Metspalu E, Parik J, Papiha S, Villems R (1999b) The place of the Indian mitochondrial DNA variants in the global network of maternal lineages and the peopling of the Old World. In: Papiha S, Deka R, Chakraborty R (eds) Genomic diversity: applications in human population genetics. Plenum, New York, pp 135–152Google Scholar
  76. Kivisild T, Tolk H-V, Parik J, Wang Y, Papiha SS, Bandelt H-J, Villems R (2002) The emerging limbs and twigs of the east Asian mtDNA tree. Mol Biol Evol 19:1737–1751 (erratum 20:162)PubMedGoogle Scholar
  77. Kivisild T, Rootsi S, Metspalu M, Mastana S, Kaldma K, Parik J, Metspalu E, Adojaan M, Tolk H-V, Stepanov V, Gölge M, Usanga E, Papiha SS, Cinnioğlu C, Kinf R, Cavalli-Sforza LL, Underhill PA, Villems R (2003) The genetic heritage of the earliest settlers persists both in Indian tribal and caste populations. Am J Hum Genet 72:313–332PubMedGoogle Scholar
  78. Kivisild T, Reidla M, Metspalu E, Rosa A, Brehm A, Pennarun E, Parik J, Geberhiwot T, Usanga E, Villems R (2004) Ethiopian mitochondrial DNA heritage: tracking gene flows across and around the Strait of Tears. Am J Hum Genet 75:752–770PubMedGoogle Scholar
  79. Kong Q-P, Yao Y-G, Sun C, Bandelt H-J, Zhu C-L, Zhang Y-P (2003) Phylogeny of East Asian mitochondrial DNA linerages inferred from complete sequences. Am J Hum Genet 73:671–676 (erratum 75:157)PubMedGoogle Scholar
  80. Krings M, Stone A, Schmitz RW, Krainitzki H, Stoneking M, Pääbo S (1997) Neandertal DNA sequences and the origin of modern humans. Cell 90:19–30PubMedGoogle Scholar
  81. Kuhn SL (2002) Paleolithic archaeology in Turkey. Evol Anthropol 11:198–210Google Scholar
  82. Labuda D, Zietkiewicz E, Yotova V (2000) Archaic lineages in the history of modern humans. Genetics 156:799–808PubMedGoogle Scholar
  83. Lahr (1996) The evolution of modern human diversity. Cambridge University Press, CambridgeGoogle Scholar
  84. Lahr MM, Foley R (1994) Multiple dispersals and modern human origins. Evol Anthropol 3:48–60Google Scholar
  85. Lahr MM, Foley R (1998) Towards a theory of modern human origins: geography, demography, and diversity in recent human evolution. Yearb Phys Anthropol 41:137–176Google Scholar
  86. Lambeck K, Chappell J (2001) Sea level change through the last glacial cycle. Science 292:679–686PubMedGoogle Scholar
  87. Latham RG (1851) Man and his migrations. van Voorst, LondonGoogle Scholar
  88. Lewin R, Foley RA (2004) Principles of human evolution. Blackwell, OxfordGoogle Scholar
  89. Luis JR, Rowold DJ, Regueiro M, Caeiro B, Cinnioğlu C, Roseman C, Underhill PA, Cavalli-Sforza LL, Herrera RJ (2004) The Levant versus the Horn of Africa: evidence for bidirectional corridors of human migrations. Am J Hum Genet 74:532–544 (erratum 74:788)PubMedGoogle Scholar
  90. Maca-Meyer N, González AM, Larruga JM, Flores C, Cabrera VM (2001) Major genomic mitochondrial lineages delineate early human expansions. BMC Genet 2:13PubMedGoogle Scholar
  91. Maca-Meyer N, González AM, Pestano J, Flores C, Larruga JM, Cabrera VM (2003) Mitochondrial DNA transit between West Asia and North Africa inferred from U6 phylogeography. BMC Genet 4:15PubMedGoogle Scholar
  92. Macaulay V, Richards M, Hickey E, Vega E, Cruciani F, Guida V, Scozzari R, Bonné-Tamir B, Sykes B, Torroni A (1999) The emerging tree of West Eurasian mtDNAs: a synthesis of control-region sequences and RFLPs. Am J Hum Genet 64:232–249PubMedGoogle Scholar
  93. Macaulay V, Hill C, Achilli A, Rengo C, Clarke D, Meehan W, Blackburn J, Semino O, Scozzari R, Cruciani F, Taha A, Shaari NK, Raja JM, Ismail P, Zainuddin Z, Goodwin W, Bulbeck D, Bandelt H-J, Oppenheimer S, Torroni A, Richards M (2005) Single, rapid coastal settlement of Asia revealed by analysis of complete mitochondrial genomes. Science 308:1034–1036PubMedGoogle Scholar
  94. McBrearty S, Brooks AS (2000) The revolution that wasn’t: a new interpretation of the origin of modern human behavior. J Hum Evol 39:453–563PubMedGoogle Scholar
  95. Mellars P (1992) Archaeology and the population-dispersal hypothesis of modern human origins in Europe. Philos Trans R Soc Lond Ser B 337:225–234Google Scholar
  96. Metspalu M, Kivisild T, Metspalu E, Parik J, Hudjashov G, Kaldma K, Serk P, Karmin M, Behar DM, Gilbert MTP, Endicott P, Mastana S, Papiha SS, Skorecki K, Torroni A, Villems R (2004) Most of the extant mtDNA boundaries in south and southwest Asia were likely shaped during the initial settlement of Eurasia by anatomically modern humans. BMC Genet 5:26PubMedGoogle Scholar
  97. Mishmar D, Ruiz-Pesini E, Golik P, Macaulay V, Clark AG, Hosseini S, Brandon M, Easley K, Chen E, Brown MD, Sukernik RI, Olckers A, Wallace DC (2003) Natural selection shaped regional mtDNA variation in humans. Proc Natl Acad Sci USA 100:171–176PubMedGoogle Scholar
  98. Nei M (1987) Molecular evolutionary genetics. Columbia University Press, New YorkGoogle Scholar
  99. Nei M, Roychoudhury AK (1993) Evolutionary relationships of human populations on a global scale. Mol Biol Evol 10:927–943PubMedGoogle Scholar
  100. Oppenheimer C (2002) Limited global change due to the largest known Quaternary eruption, Toba ∼ 74 kyr BP? Quat Sci Rev 21:1593–1609Google Scholar
  101. Oppenheimer S (2003) Out of Eden. Constable and Robinson, LondonGoogle Scholar
  102. Pakendorf B, Stoneking M (2005) Mitochondrial DNA and human evolution. Annu Rev Genomics Hum Genet 6:165–183PubMedGoogle Scholar
  103. Palanichamy Mg, Sun C, Agrawa S, Bandelt H-J, Kong Q-P, Khan F, Wang C-Y, Chaudhuri TP, Palla V, Zhang Y-P (2004) Phylogeny of mtDNA macrohaplogroup N in India based on complete sequencing: implications for the peopling of South Asia. Am J Hum Genet 75:966–978PubMedGoogle Scholar
  104. Passarino G, Semino O, Quintana-Murci L, Excoffier L, Hammer M, Santachiara-Benerecetti AS (1998) Different genetic components in the Ethiopian population, identified by mtDNA and Y-chromosome polymorphisms. Am J Hum Genet 62:420–434PubMedGoogle Scholar
  105. Pearson OM, Stone AC (2003) On the diffusion-wave model for the spread of modern humans. Curr Anthropol 44:559–561Google Scholar
  106. Penny D, Steel M, Waddell PJ, Hendy MD (1995) Improved analyses of human mtDNA sequences support a recent African origin for Homo sapiens. Mol Biol Evol 12:863–882PubMedGoogle Scholar
  107. Pereira L, Richards M, Goios A, Alonso A, Albarrán C, Garcia O, Behar D, Gölge M, Hatina J, Al-Ghazali L, Bradley DG, Macaulay V, Amorim A (2005) High-resolution mtDNA evidence for the late-glacial resettlement of Europe from an Iberian refugium. Genome Res 15:19–24PubMedGoogle Scholar
  108. Petraglia MD, Alsharek A (2003) The Middle Palaeolithic of Arabia: implications for modern human origins, behaviour and dispersals. Antiquity 77:671–684Google Scholar
  109. Phillips MS, Lawrence R, Sachidanandam R, Morris AP, Balding DJ, Donaldson MA, Studebaker JF et al (2003) Chromosome-wide distribution of haplotype blocks and the role of recombination hot spots. Nat Genet 33:382–387PubMedGoogle Scholar
  110. Quintana-Murci L, Chaix R, Wells RS, Behar DM, Sayar H, Scozzari R, Rengo C, Al-Zahery N, Semino O, Santachiara-Benerecetti AS, Coppa A, Ayub Q, Mohyuddin A, Tyler-Smith C, Mehdi SQ, Torroni A, McElreavey K (2004) Where west meets east: the complex mtDNA landscape of the Southwest and Central Asian corridor. Am J Hum Genet 74:827–845PubMedGoogle Scholar
  111. Quintana-Murci L, Semino O, Bandelt H-J, Passarino G, McElreavey K, Santachiara-Benerecetti AS (1999) Genetic evidence for an early exit of Homo sapiens sapiens from Africa through eastern Africa. Nat Genet 23:437–441PubMedGoogle Scholar
  112. Rando JC, Cabrera VM, Larruga JM, Hernández M, González AM, Pinto F, Bandelt H-J (1999) Phylogeographic patterns of mtDNA reflecting the colonization of the Canary Islands. Ann Hum Genet 63:413–428PubMedGoogle Scholar
  113. Rando JC, Pinto F, González AM, Hernández M, Larruga JM, Cabrera VM, Bandelt H-J (1998) Mitochondrial DNA analysis of Northwest African populations reveals genetic exchanges with European, Near-Eastern, and sub-Saharan populations. Ann Hum Genet 62:531–550PubMedGoogle Scholar
  114. Rayner D, Bulbeck D (2001) Dental morphology of the “Orang Asli” aborigines of the Malay Peninsula. In: Henneberg M (ed) Causes and effects of human variation, Vol 19–41. Australasian Society for Human Biology, University of Adelaide, AdelaideGoogle Scholar
  115. Redd AJ, Roberts-Thomson J, Karafet T, Bamshad M, Jorde LB, Naidu JM, Walsh B, Hammer MF (2002) Gene flow from the Indian subcontinent to Australia: evidence from the Y chromosome. Curr Biol 12:673–677PubMedGoogle Scholar
  116. Reidla M, Kivisild T, Metspalu E, Kaldma K, Tambets K, Tolk HV, Parik J et al (2003) Origin and diffusion of mtDNA haplogroup X. Am J Hum Genet 73:1178–1190PubMedGoogle Scholar
  117. Relethford JH (2001) Genetic history of the human species. In: Balding DJ, Bishop MJ, Cannings C (eds) Handbook of statistical genetics. Wiley, New York, pp 813–846Google Scholar
  118. Richards M, Macaulay V (2000) Genetic data and the colonization of Europe: genealogies and founders. In: Renfrew C, Boyle K (eds) Archaeogenetics: DNA and the population prehistory of Europe. McDonald Institute for Archaeological Research, Cambridge, pp 139–151Google Scholar
  119. Richards M, Oppenheimer S, Sykes B (1998) mtDNA suggests Polynesian origins in eastern Indonesia. Am J Hum Genet 63:1234–1236PubMedGoogle Scholar
  120. Richards M, Macaulay V, Hickey E, Vega E, Sykes B, Guida V, Rengo C et al (2000) Tracing European founder lineages in the Near Eastern mitochondrial gene pool. Am J Hum Genet 67:1251–1276PubMedGoogle Scholar
  121. Richards MB, Macaulay VA, Bandelt H-J (2002) Analyzing genetic data in a model-based framework: inferences about European prehistory. In: Renfrew C, Bellwood P (eds) Examining the farming/language dispersal hypothesis. McDonald Institute for Archaeological Research, Cambridge, pp 459–466Google Scholar
  122. Richards M, Rengo C, Cruciani F, Gratrix F, Wilson JF, Scozzari R, Macaulay V, Torroni A (2003) Extensive female-mediated gene flow from sub-Saharan Africa into Near Eastern Arab populations. Am J Hum Genet 72:1059–1064Google Scholar
  123. Roberts RG, Jones R, Smith MA (1994) Beyond the radiocarbon barrier in Australian prehistory. Antiquity 68:611–616Google Scholar
  124. Rogers AR, Harpending H (1992) Population growth makes waves in the distribution of pairwise genetic differences. Mol Biol Evol:552–569Google Scholar
  125. Rogers AR, Jorde LB (1995) Genetic evidence on modern human origins. Hum Biol 67:1–36PubMedGoogle Scholar
  126. Rohling EJ, Fenton M, Jorissen FJ, Bertrand P, Ganssen G, Caulet JP (1998) Magnitudes of sea-level lowstands of the past 500,000 years. Nature 394:162–165Google Scholar
  127. Salas A, Richards M, De la Fe T, Lareu M-V, Sobrino B, Sánchez-Diz P, Macaulay V, Carracedo Á (2002) The making of the African mtDNA landscape. Am J Hum Genet 71:1082–1111PubMedGoogle Scholar
  128. Sauer C (1962) Seashore: primitive home of man? Proc Am Philos Soc 106:41–47Google Scholar
  129. Scozzari R, Cruciani F, Santolamazza P, Malaspina P, Torroni A, Sellitto D, Arredi B, Destro-Bisol G, De Stefano G, Rickards O, Martinez-Lebarga C, Modiano D, Biondi G, Moral P, Olckers A, Wallace DC, Novelletto A (1999) Combined use of biallelic and microsatellite Y-chromosome polymorphisms to infer affinities among African populations. Am J Hum Genet 65:829–846PubMedGoogle Scholar
  130. Semino O, Passarino G, Oefner PJ, Lin AA, Arbuzova S, Beckman LE, De Benedictis G, Francalacci P, Kouvatsi A, Limborska S, Marcikiæ M, Mika A, Mika B, Primorac D, Santachiara-Benerecetti AS, Cavalli Sforza LL, Underhill PA (2000) The genetic legacy of Paleolithic Homo sapiens sapiens in extant Europeans: a Y chromosome perspective. Science 290:1155–1159PubMedGoogle Scholar
  131. Semino O, Magri C, Benuzzi G, Lin AA, Al-Zahery N, Battaglia V, Maccioni L, Triantaphyllidis C, Shen P, Oefner PJ, Zhivotovsky LA, King R, Torroni A, Cavalli-Sforza LL, Underhill PA, Santachiara-Benerecetti AS (2004) Origin, diffusion, and differentiation of Y-chromosome haplogroups E and J: inferences on the neolithization of Europe and later migratory events in the Mediterranean area. Am J Hum Genet 74:1023–1034PubMedGoogle Scholar
  132. Shen G, Wang W, Wang Q, Zhao JX, Collerson K, Zhou CL, Tobias PV (2002) U-Series dating of Liujiang hominid site in Guangxi, Southern China. J Hum Evol 43:817–829PubMedGoogle Scholar
  133. Siddall M, Rohling EJ, Almogi-Labin A, Hemleben C, Meischner D, Schmelzer I, Smeed DA (2003) Sea-level fluctuations during the last glacial cycle. Nature 423:853–858PubMedGoogle Scholar
  134. Sirocko F (2003) Global change—ups and downs in the Red Sea. Nature 423:813–814PubMedGoogle Scholar
  135. Slatkin M, Hudson RR (1991) Pairwise comparisons of mitochondrial DNA sequences in stable and exponentially growing populations. Genetics 129:555–562PubMedGoogle Scholar
  136. Song S-R, Chen C-H, Lee M-Y, Yang TF, Iizuka Y, Wei K-Y (2000) Newly disovered eastern dispersal of the youngest Toba tuff. Marine Geol 167:303–312Google Scholar
  137. Stoneking M, Fontius JJ, Clifford SL, Soodyall H, Arcot SS, Saha N, Jenkins T, Tahir MA, Deininger PL, Batzer MA (1997) Alu insertion polymorphisms and human evolution: evidence for a larger population size in Africa. Genome Res 7:1061–1071PubMedGoogle Scholar
  138. Stringer C (2000) Coasting out of Africa. Nature 405:24–27PubMedGoogle Scholar
  139. Stringer C (2002) Modern human origins: progress and prospects. Philos Trans R Soc Lond Ser B 357:563–579Google Scholar
  140. Stringer C, McKie R (1996) African exodus: the origins of modern humanity. Cape, LondonGoogle Scholar
  141. Stringer CB, Andrews P (1988) Genetic and fossil evidence for the origin of modern humans. Science 239:1263–1268PubMedGoogle Scholar
  142. Stringer CB, Grün R, Schwarcz HP, Goldberg P (1989) ESR dates for the hominid burial site of Es Skhul in Israel. Nature 338:756–758PubMedGoogle Scholar
  143. Swofford DL (1993) PAUP: phylogenetic analysis using parsimony release 3.1.1, ChampaignGoogle Scholar
  144. Sykes B, Leiboff A, Low-Beer J, Tetzner S, Richards M (1995) The origins of the Polynesians—an interpretation from mitochondrial lineage analysis. Am J Hum Genet 57:1463–1475PubMedGoogle Scholar
  145. Takahata N, Lee S-H, Satta Y (2001) Testing multiregionality of modern human origins. Mol Biol Evol 18:172–183PubMedGoogle Scholar
  146. Tanaka M, Cabrera VM, González AM, Larruga JM, Takeyasu T, Fuku N, Guo L-J et al (2004) Mitochondrial genome variation in Eastern Asia and the peopling of Japan. Genome Res 14:1832–1850PubMedGoogle Scholar
  147. Tchernov E (1992) Biochronology, paleoecology and dispersal events of hominids in the southern Levant. In: Akazawa T, Aoki K, Kimura T (eds) The evolution and dispersal of modern humans in Asia. Hokusen-sha, Tokyo, pp 149–188Google Scholar
  148. Templeton AR (2002) Out of Africa again and again. Nature 416:45–51PubMedGoogle Scholar
  149. Templeton AR (2003) Against recent replacement (Box 8.9 opinion) In: Jobling M, Hurles M, Tyler-Smith C (eds) Human evolutionary genetics: origins, peoples & disease. Taylor & Francis, London, p 261Google Scholar
  150. Thangaraj K, Singh L, Reddy AG, Rao VR, Sehgal SC, Underhill PA, Pierson M, Frame IG, Hagelberg E (2003) Genetic affinities of the Andaman Islanders, a vanishing human population. Curr Biol 13:86–93PubMedGoogle Scholar
  151. Thangaraj K, Chaubey G, Kivisild T, Reddy AG, Singh VK, Rasalkar AA, Singh L (2005) Reconstructing the origin of Andaman Islanders. Science 308:996PubMedGoogle Scholar
  152. Thorne A, Grün R, Mortimer G, Spooner NA, Simpson JJ, McCulloch M, Taylor L, Curnoe D (1999) Australia’s oldest human remains: age of the Lake Mungo 3 skeleton. Hum Evol 36:591–612Google Scholar
  153. Tishkoff SA, Dietzsch E, Speed W, Pakstis AJ, Kidd JR, Cheung K, Bonné-Tamir B, Santachiara-Benerecetti AS, Moral P, Krings M, Pääbo S, Watson E, Risch N, Jenkins T, Kidd KK (1996) Global patterns of linkage disequilibrium at the CD4 locus and modern human origins. Science 271:1380–1387PubMedGoogle Scholar
  154. Torroni A, Schurr TG, Cabell MF, Brown MD, Neel JV, Larsen M, Smith DG, Vullo CM, Wallace DC (1993) Asian affinities and continental radiation of the four founding Native American mtDNAs. Am J Hum Genet 53:563–590PubMedGoogle Scholar
  155. Torroni A, Miller JA, Moore LG, Zamudio S, Zhuang JG, Droma T, Wallace DC (1994a) Mitochondrial DNA analysis in Tibet: implications for the origin of the Tibetan population and its adaptation to high altitude. Am J Phys Anthropol 93:189–199PubMedGoogle Scholar
  156. Torroni A, Neel JV, Barrantes R, Schurr TG, Wallace DC (1994b) Mitochondrial DNA clock for the Amerinds and its implications for timing their entry into North America. Proc Natl Acad Sci USA 91:1158–1162PubMedGoogle Scholar
  157. Torroni A, Bandelt H-J, D’Urbano L, Lahermo P, Moral P, Sellitto D, Rengo C, Forster P, Savantaus M-L, Bonné-Tamir B, Scozzari R (1998) mtDNA analysis reveals a major late Paleolithic population expansion from southwestern to northeastern Europe. Am J Hum Genet 62:1137–1152PubMedGoogle Scholar
  158. Torroni A, Bandelt H-J, Macaulay V, Richards M, Cruciani F, Rengo C, Martinez-Cabrera V et al (2001) A signal, from human mtDNA, of post-glacial recolonization in Europe. Am J Hum Genet 69:844–852PubMedGoogle Scholar
  159. Underhill PA, Passarino G, Lin AA, Shen P, Mirazón Lahr M, Foley RA, Oefner PJ, Cavalli-Sforza LL (2001) The phylogeography of Y chromosome binary haplotypes and the origins of modern human populations. Ann Hum Genet 65:43–62PubMedGoogle Scholar
  160. Underhill PA, Roseman CC (2001) The case for an African rather than an Asian origin of the human Y-chromosome YAP insertion. In: Jin L, Seielstad M, Xiao C (eds) Genetic, linguistic and archaeological perspectives on human diversity in Southeast Asia. World Scientific Publishing, Singapore, pp 43–56Google Scholar
  161. Underhill PA, Shen P, Lin AA, Jin L, Passarino G, Yang WH, Kauffman E, Bonné-Tamir B, Bertranpetit J, Francalacci P, Ibrahim M, Jenkins T, Kidd JR, Mehdi SQ, Seielstad MT, Wells RS, Piazza A, Davis RW, Feldman MW, Cavalli-Sforza LL, Oefner PJ (2000) Y chromosome sequence variation and the history of human populations. Nat Genet 26:358–361PubMedGoogle Scholar
  162. Valladas H, Reyss Jl, Joron Jl, Valladas G, Bar-Yosef O, Vandermeersch B (1988) Thermoluminescence dating of Mousterian “Proto-Cro-Magnon” remains from Israel and the origin of modern man. Nature 331:614–616Google Scholar
  163. van Andel TH, Davies W, Weninger B (2003) The human presence in Europe during the last glacial period I: human migrations and the changing climate. In: van Andel TH, Davies W (eds) Neanderthals and modern humans in the European landscape during the last glaciation. McDonald Institute for Archaeological Research, Cambridge, pp 31–56Google Scholar
  164. Vigilant L, Stoneking M, Harpending H, Hawkes K, Wilson AC (1991) African populations and the evolution of human mitochondrial DNA. Science 253:1503–1507PubMedGoogle Scholar
  165. Wainscoat J, Hill A, Boyce A, Flint J, Hernandez M, Thein SL, Old JM, J.R. L, Falusi Y, Weatherall DJ, Clegg JB (1986) Evolutionary relationships of human populations from an analysis of nuclear DNA polymorphisms. Nature 319:491–493PubMedGoogle Scholar
  166. Walter RC, Buffler RT, Bruggemann JH, Guillaume MMM, Berhe SM, Negassi B, Libsekal Y, Cheng H, Edwards RL, von Cosel R, Neraudeau D, Gagnon M (2000) Early human occupation of the Red Sea coast of Eritrea during the last interglacial. Nature 405:65–69PubMedGoogle Scholar
  167. Watkins WS, Ricker CE, Bamshad MJ, Carroll ML, Nguyen SV, Batzer MA, Harpending HC, Rogers AR, Jorde LB (2001) Patterns of ancestral human diversity: an analysis of Alu-insertion and restriction-site polymorphisms. Am J Hum Genet 68:738–752PubMedGoogle Scholar
  168. Watson E, Forster P, Richards M, Bandelt H-J (1997) Mitochondrial footprints of human expansions in Africa. Am J Hum Genet 61:691–704PubMedGoogle Scholar
  169. Weale ME, Shah T, Jones AL, Greenhalgh J, Wilson JF, Nymadawa P, Zeitlin D, Connell BA, Bradman N, Thomas MG (2003) Rare deep-rooting Y chromosome lineages in humans: lessons for phylogeography. Genetics 165:229–234PubMedGoogle Scholar
  170. Wells RS, Yuldasheva N, Ruzibakiev R, Underhill PA, Evseeva I, Blue-Smith J, Jin L et al (2001) The Eurasian heartland: a continental perspective on Y-chromosome diversity. Proc Natl Acad Sci USA 98:10244–10249PubMedGoogle Scholar
  171. White TD, Asfaw B, DeGusta D, Gilbert H, Richards GD, Suwa G, Howell FC (2003) Pleistocene Homo sapiens from Middle Awash, Ethiopia. Nature 423:742–747PubMedGoogle Scholar
  172. Wilson JF, Weiss DA, Richards M, Thomas MG, Bradman N, Goldstein DB (2001) Genetic evidence for different male and female roles during cultural transitions in the British Isles. Proc Natl Acad Sci USA 98:5078–5083PubMedGoogle Scholar
  173. Wolpoff MH, Caspari R (1997) Race and human evolution. Simon and Schuster, New YorkGoogle Scholar
  174. YCC (2002) A nomenclature system for the tree of human Y-chromosomal binary haplogroups. Genome Res 12:339–348Google Scholar
  175. Yu N, Fu YX, Li WH (2002) DNA polymorphism in a worldwide sample of human X chromosomes. Mol Biol Evol 19:2131–2141PubMedGoogle Scholar
  176. Zhivotovsky LA, Underhill PA, Cinnioğlu C, Kayser M, Morar B, Kivisild T, Scozzari R, Cruciani F, Destro-Bisol G, Spedini G, Chambers GK, Herrera RJ, Yong KK, Gresham D, Tournev I, Feldman MW, Kalaydjieva L (2004) The effective mutation rate at Y chromosome short tandem repeats, with application to human population-divergence time. Am J Hum Genet 74:50–61PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Martin Richards
    • 1
  • Hans-Jürgen Bandelt
    • 1
  • Toomas Kivisild
    • 1
  • Stephen Oppenheimer
    • 1
  1. 1.Institute of Integrative & Comparative Biology, Faculty of Biological SciencesUniversity of LeedsLeedsUK

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