Zusammenfassung
Die Kinetik von Zellproliferation und Zellverlust ist altersabhängig sowie organspezifisch und wird bestimmt durch die Proliferationskompetenz der individuellen Zelle, der inter- und intrazellulären Kommunikation, dem humoralen Mikromilieu und übergeordneten systemischen humoralen, hormonellen und zellulären Faktoren.
Preview
Unable to display preview. Download preview PDF.
Literatur
- Bartsch H (1996) DNA adducts in human carcinogenesis: etiological relevance and structure-activity relationship. Mutat Res 340:67–79PubMedGoogle Scholar
- Baylin SB (1997) Tying it all together: epigenetics, genetics, cell cycle, and cancer. Science 277:1948–1949PubMedCrossRefGoogle Scholar
- Chaney SG, Sancar A (1996) DNA repair: enzymatic mechanisms and relevance to drug response. J Natl Cancer Inst 88:1346–1360PubMedCrossRefGoogle Scholar
- Doll R (1998) Epidemiological evidence of the effects of behaviour and the environment on the risk of human cancer. In: Schwab B, Rabes H, Munk K, Hofschneider PH (eds) Genes and environment in cancer. Springer, Berlin, pp 3–21Google Scholar
- Friedberg EC, Walker GC, Siede W (1995) DNA repair and mutagenesis. ASM, Washington DCGoogle Scholar
- Harris CC (1996) The 1995 Walter Hubert lecture — Molecular epidemiology of human cancer: insights from the mutational analysis of the p53 tumour suppressor gene. Br J Cancer 73:261–269PubMedGoogle Scholar
- Huebner K, Hadaczek P, Siprashvili Z et al (1997) The FHIT gene, a multiple tumor suppressor gene encompassing the carcinogen sensitive chromosome fragile site, FRA3B. Biochim Biophys Acta 1332:M65–M70PubMedGoogle Scholar
- International Agency for Research on Cancer (1992) Solar and ultraviolet radiation. IARC Monogr Eval Carcinog Risks Hum 55:1–316Google Scholar
- Perera FP (1997) Environment and cancer: who are susceptible? Science 278:1068–1073PubMedCrossRefGoogle Scholar
- Rabes HM, Klugbauer S (1998) Molecular genetics of childhood papillary thyroid carcinomas after irradiation: high prevalence of RET rearrangement. In: Schwab B, Rabes H, Munk K, Hofschneider PH (eds) Genes and environment in cancer. Springer, Berlin, pp 248–264Google Scholar
- Schwab B, Rabes H, Munk K, Hofschneider PH (eds) (1998) Genes and environment in cancer. Springer, BerlinGoogle Scholar
- Yamagiwa K, Ichikawa K (1918) Experimental study of the pathogenesis of carcinoma. J Cancer Res 3:1–29Google Scholar
Copyright information
© Springer Medizin Verlag Heidelberg 2006