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Rotavirus Proteins: Structure and Assembly

  • J. B. Pesavento
  • S. E. Crawford
  • M. K. Estes
  • B. V. Venkataram Prasad
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 309)

Abstract

Rotavirus is a major pathogen of infantile gastroenteritis. It is a large and complex virus with a multilayered capsid organization that integrates the deter minants of host specificity, cell entry, and the enzymatic functions necessary for endogenous transcription of the genome that consists of 11 dsRNA segments. These segments encode six structural and six nonstructural proteins. In the last few years, there has been substantial progress in our understanding of both the structural and functional aspects of a variety of molecular processes involved in the replication of this virus. Studies leading to this progress using of a variety of structural and biochemical techniques including the recent application of RNA interference technology have uncovered several unique and intriguing features related to viral morphogenesis. This review focuses on our current understanding of the structural basis of the molecular processes that govern the replication of rotavirus.

Keywords

Nonstructural Protein Rice Dwarf Virus dsRNA Segment Endogenous Transcription Cell Entry Process 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • J. B. Pesavento
    • 1
  • S. E. Crawford
    • 2
  • M. K. Estes
    • 2
  • B. V. Venkataram Prasad
    • 1
  1. 1.Verna and Marrs McLean Department of Biochemistry and Molecular BiologyBaylor College of MedicineHoustonUSA
  2. 2.Department of Molecular Virology and MicrobiologyBaylor College of MedicineHoustonUSA

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