Antimicrobial Peptides and Human Disease pp 67-90

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 306)

Host Antimicrobial Defence Peptides in Human Disease

  • B. Agerberth
  • G. H. Guðmundsson

Abstract

Antimicrobial peptides or host defence peptides are endogenous peptide antibiotics, which have been confirmed as an essential part of the immune system. Apart from direct killing of bacteria, a role for the peptides in antiviral and immunomodulatory functions has recently been claimed. In this chapter we have focused on the host contact with microbes, where these host defence peptides are key players. The interplay with commensals and pathogens in relation to antimicrobial peptide expression is discussed, with specific emphasis on the respiratory and the alimentary systems. A possible novel difference in epithelial interactions between commensals and pathogens is considered in relation to disease.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • B. Agerberth
    • 1
  • G. H. Guðmundsson
    • 2
  1. 1.Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSweden
  2. 2.Biology InstituteUniversity of IcelandReykjavikIceland

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