Hepatitis Delta Virus Genetic Variability: From Genotypes I, II, III to Eight Major Clades?
- P. DényAffiliated withService de Bactériologie, Virologie, Hygiène, Laboratoire Associé au Centre National de Référence des hépatites B et C, Hôpital Avicenne, Assistance Publique — Hôpitaux de Paris, Université Paris 13, EA3406
Hepatitis D virus (HDV) is a satellite of hepatitis B virus (HBV) for transmission and propagation, and infects nearly 20 million people worldwide. The HDV genome is composed of a compact circular single-stranded negative RNA genome with extensive intramolecular complementarity. Along with epidemiological, geographic distribution and pathological patterns, the variability of HDV has been limited to three genotypes and two subtypes that have been characterized to date. Recently, extensive phylogenetic reconstructions based on the delta antigen gene and full-length genome sequence data, have shown a wide and probably ancient radiation of African lineages, suggesting that the genetic variability of HDV is much more complex than previously thought. Indeed, sequences previously affiliated with genotype IIb should now be considered as belonging to clade 4 (HDV-4) and African HDV sequences segregate within four additional clades: HDV-5, HDV-6, HDV-7 and HDV-8. These results bring the geographic distribution of HDV closer to the genetic variability of its helper HBV.
- Hepatitis Delta Virus Genetic Variability: From Genotypes I, II, III to Eight Major Clades?
- Book Title
- Hepatitis Delta Virus
- pp 151-171
- Print ISBN
- Online ISBN
- Series Title
- Current Topics in Microbiology and Immunology
- Series Volume
- Series ISSN
- Springer Berlin Heidelberg
- Copyright Holder
- Springer-Verlag Berlin Heidelberg
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- Editor Affiliations
- 9. Department of Microbiology and Immunology, Georgetown University
- P. Dény (10)
- Author Affiliations
- 10. Service de Bactériologie, Virologie, Hygiène, Laboratoire Associé au Centre National de Référence des hépatites B et C, Hôpital Avicenne, Assistance Publique — Hôpitaux de Paris, Université Paris 13, EA3406, 93009, Bobigny Cedex, France
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