Neuroaktive Steroide

  • A. Ströhle
Chapter

Zusammenfassung

Neuroaktive Steroide können im Gehirn ohne Zuhilfenahme peripherer Ressourcen synthetisiert werden. In den vergangenen Jahren fanden sich darüber hinaus Hinweise für Interaktionen von Steroiden mit Neurotransmitterrezeptoren und eine Modulation der neuronalen Erregbarkeit über membranäre Prozesse. Die GABAA-Rezeptor-modulierende Aktivität 3α-reduzierter neuroaktiver Steroide konnte im Tier- und teilweise auch im Humanexperiment mit einer Vielzahl von Verhaltenseffekten in Verbindung gebracht werden. Daneben gibt es aus verschiedenen Arbeitsgruppen Hinweise für eine Rolle neuroaktiver Steroide in der Depression und ihrer Behandlung. Neben der direkten Verabreichung (synthetischer Analoga) neuroaktiver Steroide könnte auch eine Beeinflussung ihrer Metabolisierung einen neuen Ansatz zur Behandlung affektiver Störungen darstellen.

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© Springer Medizin Verlag Heidelberg 2005

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  • A. Ströhle

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