Naturally Arising CD25+CD4+ Regulatory T Cells in Tumor Immunity

  • T. Nomura
  • S. Sakaguchi

Abstract

Naturally arising regulatory T (TR) cells, represented by CD25+CD4+ TR cells, play an essential role in maintaining immunological self-tolerance. This T cell-mediated dominant control of the immune response not only inhibits the development of autoimmune disease, but also impedes effective immunosurveillance against autologous tumor cells. Attenuation of TR cell-mediated immune suppression can therefore evoke effective tumor immunity in otherwise nonresponsive animals. This common regulatory mechanism for autoimmunity and tumor immunity can be exploited when devising a novel immunotherapy for cancer.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • T. Nomura
    • 1
  • S. Sakaguchi
    • 1
  1. 1.Department of Experimental Pathology, Institute for Frontier Medical SciencesKyoto UniversityKyotoJapan

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